MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma

Heß, Anne-Katrin; Müer, Annika; Mairinger, Fabian; Weichert, Wilko; Stenzinger, Albrecht; Hummel, Michael; Budach, Volker; Tinhofer, Ingeborg

doi:10.1016/j.ejca.2017.02.018

Cited by 56 publications

(39 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overexpression of miR-142-3p, 146a, 26b was positively correlated to overall survival, while miR-31, 24, 193b was negatively correlated in a study by Gao et al (73). In another study on clinical outcome in relation to different chemo-radiotherapy combinations, miR-146a, 155, 200b were correlated to treatment outcome, with the first two independent of tumor HPV status (72).…”

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 94%

“…MicroRNA (miR) expression in OPSCC has been mainly analyzed in normal tissue, HPV-positive vs. HPV-negative tumor status and to a lesser extent to outcome (67)(68)(69)(70)(71)(72)(73). The results varied, with many miRs proposed to correlate with tumor HPV status or outcome, with few miRs found common between studies.…”

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 99%

“…Few studies have analyzed miR expression in OPSCC in relation both to HPV and clinical outcome and these miRs differ between the studies (71)(72)(73). Overexpression of miR-142-3p, 146a, 26b was positively correlated to overall survival, while miR-31, 24, 193b was negatively correlated in a study by Gao et al (73).…”

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 99%

See 2 more Smart Citations

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

Näsman

Bersani

Lindquist

et al. 2017

View full text Add to dashboard Cite

Abstract. Human papillomavirus (HPV)-positive tonsillarand base of tongue cancer is increasing epidemically and has much better outcome than corresponding HPV-negativeIn 2007, human papillomavirus (HPV) was recognized as a risk factor for oropharyngeal squamous cell carcinoma (OPSCC) by the International Agency for Research against Cancer (IARC), besides the traditional risk factors smoking and alcohol (1-4). Concurrently, an increased incidence of OPSCC, more specifically tonsillar and base of tongue cancer (TSCC and BOTSCC, the two main HPV-positive OPSCC sites) was described in many developed countries, and found to be due to a sharp rise of HPV-positive cases (5-18). These HPV-positive tumors had a much better clinical outcome than their HPV-negative counterparts and head and neck squamous cell carcinoma (HNSCC) in general when treated with radiotherapy and surgery (1-3, 15-17, 19, 20). Treatment of HNSCC including OPSCC has, however, gradually become more intensified with induction chemotherapy or concurrent chemo-radiotherapy and sometimes the administration of Erbitux, leading to more severe side effects (16, 20, 21). This is likely unnecessary for most HPV-positive TSCC and BOTSCC patients since they generally respond well to less therapy and furthermore, intensified therapy does not improve survival of [15][16][17] 20, 22, 23). It is, therefore, important to identify patients with HPV-positive TSCC and BOTSCC eligible for less treatment or targeted therapy and efforts focus now on finding predictive and targetable markers for these patients (24-39).Here, a short background of the field and an update on recent attempts to find predictive and targetable markers with different methodologies for individualized therapy is presented. Human Papillomavirus in Tonsillar and Base of Tongue Squamous Cell Carcinoma and an Epidemic Increase of these TumorsIn 2000, an association between HPV and OPSCC and TSCC was reported, and with radiotherapy and surgery, these HPVpositive cases had much better outcome than corresponding HPV-negative cases (80% vs. 40-50% 5-year survival) (1, 2). In 2004, a similar relationship of HPV to BOTSCC, but not to mobile tongue cancer was disclosed (40). Based on 5319

show abstract

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 94%

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 99%

Section: Microrna Expression In Oropharyngeal Cancer In Relation To Hmentioning

confidence: 99%

See 1 more Smart Citation

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

Näsman

Bersani

Lindquist

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In a study exploring miRNAs as predictive biomarkers of the efficacy of peptide vaccines alone (phase I) and in combination with chemotherapy (phase II) in colorectal cancer, hsa-miR-125b-1 and hsa-miR-378a have been negatively associated with overall survival [35]. The predictive value of miRNAs in tumor cells and infiltrating immune cells for the efficacy of radiotherapy in combination with either 5-fluorouracil/cisplatin (CDDP-CRTX) or 5-fluorouracil/ mitomycin C, in locally advanced head and neck squamous cell carcinoma, was evaluated in a phase III trial highlighting hsa-miR-200b and hsa-miR-155 as potential markers for personalized treatment selection of two standard regimens of chemoradiation [36]. In a large multicenter study investigating the effect of adding bevacizumab to standard chemotherapy in patients diagnosed with epithelial ovarian cancer, low levels of hsa-miR-200b, hsa-miR-1274A (tRNA Lys5 ), and hsa-miR-141 were significantly associated with better survival, and the level of hsa-miR-200c seemed predictive of effect of treatment with bevacizumab [37].…”

Section: Overview On Present or Future Clinical Applications Of Mirnasmentioning

confidence: 99%

Free Circulating miRNAs Measurement in Clinical Settings

Faraldi

Banfi

Lombardi

2018

Advances in Clinical Chemistry

View full text Add to dashboard Cite

“…MiR-155 was overexpressed in OSCC, and it was located in the cancer nest, inflammatory area, and vascular endothelium of OSCC suggesting that high miRNA-155 expression level in cancer-free mucosal tissues may predict poor prognosis in patients with OSCC [73]. A recent study found that miR-200b and miR-155 could be potential markers for personalised treatment selection of two standard regimens of chemoradiation in patients with HNSCC [75].…”

Section: Mirna Profile Of Oral Squamous Cell Carcinomamentioning

confidence: 99%

Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature

Tonchev¹,

Vladimirov²,

Sarafian³

et al. 2017

Int J Surg Med

View full text Add to dashboard Cite

Oral squamous cell carcinoma (OSCC) is the most common cancer type arising in the oral cavity and belongs to the wider group of head and neck cancers (HNCs).MicroRNAs (miRNAs) in mature form are noncoding RNAs, that regulate posttranscriptional gene expression by relatively nonspecific binding.As a result a single miRNA may regulate/control the expression of several genes which are involved in a variety of cellular processes like regulation of cellular differentiation, proliferation and apoptosis thus playing a role in cancer development.The AIM of this review was to summarize current findings on the effect of HPV status and presence of risk factors -smoking and alcohol consumption on miRNA expression as cancer biomarkers in patients with OSCC.

show abstract

MiR-200b and miR-155 as predictive biomarkers for the efficacy of chemoradiation in locally advanced head and neck squamous cell carcinoma

Cited by 56 publications

References 39 publications

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

Human Papillomavirus and Potentially Relevant Biomarkers in Tonsillar and Base of Tongue Squamous Cell Carcinoma

Free Circulating miRNAs Measurement in Clinical Settings

Effect of HPV status, smoking and alcohol consumption, on miRNA expression in oral cancer - a review of the literature

Contact Info

Product

Resources

About