miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells

Lee, Seul-Ah; Kim, Jae-Sung; Park, Sunyoung; Kim, Heung-Joong; Yu, Sun‐Kyoung; Kim, Chun Sung; Chun, Hong Sung; Kim, Jeongsun; Park, Jong-Tae; Go, Dae-San; Kim, Do Kyung

doi:10.1016/j.jbiosc.2015.02.002

Cited by 32 publications

(16 citation statements)

References 62 publications

(65 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chen et al (33) found that miR-203 inhibited the proliferation and invasion of non-small cell lung cancer cells by targeting Bmi1. In addition, miR-203 suppresses proliferation and induces apoptosis of human oral cancer cells (34). In the present study, it was found that treatment with E2 induced a significant decrease in miR-203 levels in breast cancer cells, suggesting that it may be involved in E2-mediated malignant progression of breast cancer MCF-7 cells.…”

Section: Discussionsupporting

confidence: 55%

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Lin

Wang

Gao

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 55%

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

Lin

Wang

Gao

et al. 2017

Experimental and Therapeutic Medicine

View full text Add to dashboard Cite

show abstract

“…showed that miR-203 could be a potential prognostic marker and functions as a tumor suppressor in human renal cancer by post-transcriptionally targeting FGF2. Moreover, Lee et al[ 34 ]. demonstrated that miR-203 induces the cells apoptosis by directly targeting Yes-1 in oral cancer cells.…”

Section: Introductionmentioning

confidence: 99%

miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A

2015

View full text Add to dashboard Cite

microRNAs (miRNAs), small noncoding RNAs of 19–25 nt, play an important roles in the pathological processes of tumorigenesis. The object of this study was to study the expression and function of miR-203 and to found its target gene in osteosarcoma. In our study, we found the expression level of miR-203 was significantly downregulated in osteosarcoma cell lines and tissues. In addition, overexpression of miR-203 inhibited the osteosarcoma cell proliferation and migration and inhibited Mesenchymal-to-Epithelial reversion Transition (MErT). Moreover, we identified RAB22A as a direct target of miR-203 and RAB22A overexpression blocks the roles of miR-203 in osteosarcoma cell. Furthermore, we demonstrated that RAB22A expression was upregulated in human osteosarcoma cell lines and tissues. Take together, our results demonstrated that miR-203 act as a tumor suppressor miRNA through regulating RAB22A expression and suggested its involvement in osteosarcoma progression and carcinogenesis.

show abstract

“…YES1 is suppressed by miRNAs in the tumor progression of oral cancer, ovarian cancer, and hepatocellular carcinoma, and this observation indicates that YES1 may be regulated by miRNAs in GC [ 30 – 32 ]. Although in silico analysis suggests that YES1 is a target gene of miR-140-5p, neither the putative interaction nor the functional role of YES1 in GC has been defined.…”

Section: Discussionmentioning

confidence: 99%

miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

et al. 2017

View full text Add to dashboard Cite

BackgroundThe aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p in GC was investigated and YES1 was identified as a novel target of miR-140-5p in regulating tumor progression.MethodsmiR-140-5p level was determined in 20 paired frozen specimens through quantitative real-time PCR, and analyzed in tissue microarrays through in situ hybridization. The target of miR-140-5p was verified through a dual luciferase reporter assay, and the effects of miR-140-5p on phenotypic changes in GC cells were investigated in vitro and in vivo.ResultsCompared with that in adjacent normal tissues, miR-140-5p expression decreased in cancerous tissues. The downregulated miR-140-5p in 144 patients with GC was significantly correlated with the reduced overall survival of these patients. miR-140-5p could inhibit GC cell proliferation, migration and invasion by directly targeting 3′–untranlated region of YES1. miR-140-5p could also remarkably reduce the tumor size in GC xenograft mice.ConclusionsmiR-140-5p serves as a potential prognostic factor in patients with GC, and miR-140-5p mediated YES1 inhibition is a novel mechanism behind the suppressive effects of miR-140-5p in GC.Electronic supplementary materialThe online version of this article (doi:10.1186/s12943-017-0708-6) contains supplementary material, which is available to authorized users.

show abstract

miR-203 downregulates Yes-1 and suppresses oncogenic activity in human oral cancer cells

Cited by 32 publications

References 62 publications

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

MiR-203 inhibits estrogen-induced viability, migration and invasion of estrogen receptor α-positive breast cancer cells

miR-203 Acts as a Tumor Suppressor Gene in Osteosarcoma by Regulating RAB22A

miR-140-5p suppresses the proliferation, migration and invasion of gastric cancer by regulating YES1

Contact Info

Product

Resources

About