MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells

Li, Peipei; Tang, Gang-Bin; Xu, Ya-Jie; Zeng, Yu-Qiang; Zhang, Shuang-Feng; Du, Heng; Teng, Zhao‐Qian; Changmei, Liu

doi:10.1016/j.stemcr.2017.05.007

Cited by 27 publications

(29 citation statements)

References 61 publications

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“…miR-203 located on human chromosome 14q32 is a putative tumor suppressor gene. RE1 silencing transcriptional factor (REST), EZH2 and SNAI1/2 are upstream transcriptional repressors of miR-203 [ 84 , 85 , 86 , 87 ].…”

Section: Mirnas For Stem Cell Regulation In the Human Colorectal Cmentioning

confidence: 99%

“…Deletion of p63 in mice results in a dramatic loss of all keratinocytes and loss of stratified epithelia, probably due to a premature proliferative exhaustion of the stem and transient amplifying cells [ 89 ]. On the other hand, the EZH2-miR-203-BMI1 regulatory axis functions for the proliferation of neural stem/progenitor cells [ 87 ]. Overexpression of miR-203 suppresses the expression of BMI1 and colony formation in esophageal squamous cell carcinoma cell line [ 90 ].…”

Section: Mirnas For Stem Cell Regulation In the Human Colorectal Cmentioning

confidence: 99%

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Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells

Mukohyama

Shimono

Minami

et al. 2017

Cancers

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Colorectal cancer stem cells (CSCs) are responsible for the initiation, progression and metastasis of human colorectal cancers, and have been characterized by the expression of cell surface markers, such as CD44, CD133, CD166 and LGR5. MicroRNAs (miRNAs) are differentially expressed between CSCs and non-tumorigenic cancer cells, and play important roles in the maintenance and regulation of stem cell properties of CSCs. RNA binding proteins (RBPs) are emerging epigenetic regulators of various RNA processing events, such as splicing, localization, stabilization and translation, and can regulate various types of stem cells. In this review, we summarize current evidences on the roles of miRNA and RBPs in the regulation of colorectal CSCs. Understanding the epigenetic regulation of human colorectal CSCs will help to develop biomarkers for colorectal cancers and to identify targets for CSC-targeting therapies.

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Section: Mirnas For Stem Cell Regulation In the Human Colorectal Cmentioning

confidence: 99%

Section: Mirnas For Stem Cell Regulation In the Human Colorectal Cmentioning

confidence: 99%

Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells

Mukohyama

Shimono

Minami

et al. 2017

Cancers

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“…Interestingly, miR-203, a microRNA we have recently found to inhibit proliferation via Bmil repression in NSPCs [31], was under regulation of bivalent promoters and dis-played an increased histone Kcr level at its proximal promoter regions, as well as upregulation of expression after crotonate treatment in NSPCs (Fig 5E-5G and S7A-C Fig). In consistent with our previous findings, a reduction of both mRNA and protein levels of Bmi1 was observed concordant with up-regulation of miR-203 (Fig 5H and 5I).…”

Section: Resultsmentioning

confidence: 96%

“…Immunocytochemistry and Immunostaining was performed as previously described [31]. DAPI (Sigma-Aldrich) was used to label the cell nucleus.…”

Section: Methodsmentioning

confidence: 99%

Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters

Liu

Dai

et al. 2020

Preprint

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Histone lysine crotonylation (Kcr), an evolutionarily conserved and widely expressed non-acetyl short-chain lysine acylation, plays important roles in transcriptional regulation and disease development. However, its genome-wide distribution, correlation with gene expression, and dynamic changes during developmental processes are largely unknown. In this study, we find that histone Kcr is mainly distributed in active promoters, has a ge-nome-wide positive correlation with transcriptional activity, and regulates transcription of genes participating in metabolism and proliferation. Moreover, elevated histone Kcr activates bivalent promoters to stimulate gene expression in neural stem/progenitor cells (NSPCs), through increasing chromatin openness and recruitment of RNA polymerase II (Pol II). Functionally, these activated genes remodel transcriptome and promote neuronal differentiation.Author summaryOverall, histone Kcr marks active promoters with high gene expression and modifies the local chromatin environment to allow gene activation, which influences neuronal cell fate. It may represent a unique active histone mark involved in neural developmental regulation.

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“…Additionally, other miRNAs targeting epigenetic regulation have been found to play a role in proliferation. Differentiation induced downregulation of miR-203 occurs in NSCs and negatively regulates proliferation through targeting Bmi1 mRNA which is part of a well-studied repressive epigenetic complex, the Polycomb Repressive Complex (PRC) ( Liu P.P. et al, 2017 ).…”

Section: Classes Of Ncrnas Associated With Adult Neurogenesismentioning

confidence: 99%

Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders

Oliver

Mandyam

2018

Front. Neurosci.

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The discovery of non-coding RNAs (ncRNAs)has been one of the central findings from early genomic sequencing studies. Not only was the presence of these genes unknown previously, it was the staggering disproportionate share of the genome that was predicted to be encoded by ncRNAs that was truly significant in genomic research. Over the years the function of various classes of these ncRNAs has been revealed. One of the first and enduring regulatory programs associated with these factors was development. In the neurosciences, the discovery of adult derived populations of dividing cells within the brain was equally substantial. The brain was hypothesized to be plastic only in its neuronal connectivity, but the discovery of the generation of new neurons was a novel mechanism of neuronal and behavioral plasticity. The process of adult neurogenesis resembles early neuronal development and has been found to share many parallels in the proper stages of specified genetic programs. Adult neurogenesis has also been found to play a role in learning and memory involved in particular hippocampal-dependent behaviors. Substance use disorders (SUDs) are an example of a behavioral condition that is associated with and possibly driven by hippocampal alterations. Our laboratory has determined that hippocampal adult neurogenesis is necessary for a rodent model of methamphetamine relapse. Due to the previous research on ncRNAs in development and in other brain regions involved in SUDs, we posit that ncRNAs may play a role in adult neurogenesis associated with this disorder. This review will cover the regulatory mechanisms of various classes of ncRNAs on the coordinated genetic program associated with adult neurogenesis with a special focus on how these programs could be dysregulated in SUDs.

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MiR-203 Interplays with Polycomb Repressive Complexes to Regulate the Proliferation of Neural Stem/Progenitor Cells

Cited by 27 publications

References 61 publications

Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells

Roles of microRNAs and RNA-Binding Proteins in the Regulation of Colorectal Cancer Stem Cells

Histone lysine crotonylation regulates cell-fate determination of neural stem/progenitor cells by activating bivalent promoters

Regulation of Adult Neurogenesis by Non-coding RNAs: Implications for Substance Use Disorders

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