miR‐203a‐3p.1 targets <scp>IL</scp>‐24 to modulate hepatocellular carcinoma cell growth and metastasis

Huo, Wei; Du, Min; Pan, Xinyan; Zhu, Xiaomin; Gao, Yu; Li, Zhimin

doi:10.1002/2211-5463.12248

Cited by 41 publications

(25 citation statements)

References 23 publications

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“…MiR203a-3p.1, in particular, is up-regulated in HCC and acts as an onco-miRNA, promoting cell proliferation and metastasis, by directly targeting and repressing IL-24, a well-known anti-tumour, anti-angiogenic and anti-metastatic cytokine. MiR 203a-3p.1 and IL-24 then emerge as potential drug targets for HCC [129,130].…”

Section: Role Of Cyclic Amp In Hepatocellular Carcinomamentioning

confidence: 99%

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma

Massimi

Ragusa

Cardarelli

et al. 2019

Cells

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Hepatocellular carcinoma (HCC) is a major healthcare problem worldwide, representing one of the leading causes of cancer mortality. Since there are currently no predictive biomarkers for early stage diagnosis, HCC is detected only in advanced stages and most patients die within one year, as radical tumour resection is generally performed late during the disease. The development of alternative therapeutic approaches to HCC remains one of the most challenging areas of cancer. This review focuses on the relevance of cAMP signalling in the development of hepatocellular carcinoma and identifies the modulation of this second messenger as a new strategy for the control of tumour growth. In addition, because the cAMP pathway is controlled by phosphodiesterases (PDEs), targeting these enzymes using PDE inhibitors is becoming an attractive and promising tool for the control of HCC. Among them, based on current preclinical and clinical findings, PDE4-specific inhibitors remarkably demonstrate therapeutic potential in the management of cancer outcomes, especially as adjuvants to standard therapies. However, more preclinical studies are warranted to ascertain their efficacy during the different stages of hepatocyte transformation and in the treatment of established HCC.

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Section: Role Of Cyclic Amp In Hepatocellular Carcinomamentioning

confidence: 99%

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma

Massimi

Ragusa

Cardarelli

et al. 2019

Cells

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“…xenograft tumor growth and lung metastasis in vivo [51]. On the other hand, in hepatocellular carcinoma cells, miR-203a-3p.1 overexpression was reported to be oncogenic [52].…”

Section: Discussionmentioning

confidence: 99%

A preliminary study of microRNA expression in different types of primary melanoma

Gencia

Baderca

Avram

et al. 2019

Bosn J of Basic Med Sci

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MicroRNAs (miRNAs) have been proven to regulate the development and progression of cancer through various mechanisms. The aim of the present study was to compare miRNA expression between primary melanomas from different sites. We analyzed the expression of 84 miRNAs in 27 primary melanoma and 5 nevus formalin-fixed paraffin-embedded (FFPE) samples using the Human Cancer PathwayFinder miScript miRNA PCR Array. The FFPE samples were obtained from the archives of the Municipal Clinical Emergency Hospital of Timisoara and included 10 cutaneous melanomas, 10 uveal melanomas, 7 mucosal melanomas, and 5 cutaneous nevi. Out of 84 miRNAs, 11 miRNAs showed altered expression in all types of melanoma compared with the nevi. Among these, miR-155-5p, miR-9-5p, miR-142-5p, miR-19a-3p, miR-134-5p, and miR-301a-3p were upregulated, while miR-205-5p, miR-203a-3p, miR-27b-3p, miR-218-5p, and miR-23b-3p were downregulated. The highest similarity in miRNA expression pattern was found between uveal and mucosal melanoma groups, i.e., 15 miRNAs had altered expression in both groups. Overall, we identified several miRNAs with significantly altered expression in primary melanomas, including those reported for the first time in this type of cancer. Among them, mir-9-5p, mir-203a-3p, mir-19a-3p, mir-27b-3p, and mir-218-5p showed altered expression in all melanoma groups vs. nevus group. Further research should explore the potential of these miRNAs in melanoma.

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“…Overexpression of miR-135a promoted HCC cells migration and invasion by targeting forkhead box O1 (FOXO1) 30 . High expression of miR-203a-3p.1 could improve HCC migration and invasion by targeting IL-24 in HCC 35 . Upregulated miR-892a 48 and miR-1246 49 expression were observed to enhance HCC cells migration and invasion.…”

Section: Mirnas and Metastasis Of Hccmentioning

confidence: 99%

“…MiR-155-5p was found to elevate HCC cells proliferation ability but inhibit apoptosis 31 . High expression of miR-203a-3p.1 could improve HCC cell proliferation by targeting interleukin-24 (IL-24) in HCC 35 .…”

Section: Mirnas and Proliferation And Apoptosis Of Hccmentioning

confidence: 99%

The Role of MicroRNAs in Hepatocellular Carcinoma

et al. 2018

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Hepatocellular carcinoma (HCC) is one of the most common cancers, leading to the second cancer-related death in the global. Although the treatment of HCC has greatly improved over the past few decades, the survival rate of patients is still quite low. Thus, it is urgent to explore new therapies, especially seek for more accurate biomarkers for early diagnosis, treatment and prognosis in HCC. MicroRNAs (miRNAs), small noncoding RNAs, are pivotal participants and regulators in the development and progression of HCC. Great progress has been made in the studies of miRNAs in HCC. The key regulatory mechanisms of miRNAs include proliferation, apoptosis, invasion, metastasis, epithelial-mesenchymal transition (EMT), angiogenesis, drug resistance and autophagy in HCC. And exosomal miRNAs also play important roles in proliferation, invasion, metastasis, and drug resistance in HCC by regulating gene expression in the target cells. In addition, some miRNAs, including exosomal miRNAs, can be as potential diagnostic and prediction markers in HCC. This review summarizes the latest researches development of miRNAs in HCC in recent years.

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miR‐203a‐3p.1 targets IL‐24 to modulate hepatocellular carcinoma cell growth and metastasis

Cited by 41 publications

References 23 publications

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma

Targeting Cyclic AMP Signalling in Hepatocellular Carcinoma

A preliminary study of microRNA expression in different types of primary melanoma

The Role of MicroRNAs in Hepatocellular Carcinoma

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