Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans

Huang, Shuichuan; Wang, Mian; Wu, Weibin; Wang, Rui; Cui, Jin; Li, Wen; Li, Zilun; Wang, Shenming

doi:10.1159/000480212

Cited by 71 publications

(54 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This notion was strongly supported by a recent study showing higher serum HMGB-1 levels in patients with type 2 diabetes affected by PAD [93]. Furthermore, the expression of HMGB-1 increased in diabetic foot atherogenesis and arteriosclerosis obliterans [94,95].…”

Section: Figmentioning

confidence: 58%

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Pei

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

High mobility group box-1 (HMGB-1), a typical damage-associated molecular pattern protein released from various cells, was first identified in 1973. It is usually stored in the nuclei of cells. Several modifications of HMGB-1 promote its translocation to the cytosol, and it is actively or passively released from cells. When outside of the cells, HMGB-1is crucial in inflammation. It exerts its biological functions via interaction with its receptors, including receptor for advanced glycation end products (RAGE) and Toll-like receptor 4(TLR4). A large number of studies showed a close link between inflammation and thrombosis. This review demonstrated the increased expression of HMGB-1 in thrombosis-related diseases, including coronary artery disease, stroke, peripheral arterial disease, disseminated intravascular coagulation, and venous thrombosis. Besides, it summarized the current understanding of the emerging link between HMGB-1 and thrombosis from three aspects: platelet, NETs, and coagulation and fibrinolysis factors. Finally, it explored the possible therapeutic strategies targeting HMGB-1 for treating thrombosis-related diseases.

show abstract

Section: Figmentioning

confidence: 58%

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Pei

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

show abstract

“…HMGB1 is highly expressed in human atherosclerotic lesions and it has been involved in arteriosclerosis . For instance, miR‐22‐3p can repress arterial smooth muscle cell proliferation and migration by targeting HMGB1 in arteriosclerosis . MiR‐126 inhibits inflammation in endothelial cells through targeting HMGB1 .…”

Section: Discussionmentioning

confidence: 99%

“…[27][28][29] For instance, miR-22-3p can repress arterial smooth muscle cell proliferation and migration by targeting HMGB1 in arteriosclerosis. 30 MiR-126 inhibits inflammation in endothelial cells through targeting HMGB1. 31 MiR-24 depresses vascular smooth muscle cell proliferation and migration by reducing HMGB1.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‐328 ameliorates oxidized low‐density lipoprotein‐induced endothelial cells injury through targeting HMGB1 in atherosclerosis

Zhou

Wang

et al. 2018

J of Cellular Biochemistry

View full text Add to dashboard Cite

Atherosclerosis has been recognized as a chronic inflammatory disease, which can harden the vessel wall and narrow the arteries. MicroRNAs exhibit crucial roles in various diseases including atherosclerosis. However, so far, the role of miR‐328 in atherosclerosis remains barely explored. Therefore, our study concentrated on the potential role of miR‐328 in vascular endothelial cell injury during atherosclerosis. In our current study, we observed that oxidized low‐density lipoprotein (ox‐LDL)‐induced human umbilical vein endothelial cells (HUVECs) apoptosis and inhibited cell viability dose‐dependently and time‐dependently. In addition, indicated dosage of ox‐LDL obviously triggered HUVECs inflammation and oxidative stress process. Then, it was found that miR‐328 in HUVECs was reduced by ox‐LDL. HUVECs apoptosis was greatly repressed and cell survival was significantly upregulated by overexpression of miR‐328. Furthermore, mimics of miR‐328 rescued cell inflammation and oxidative stress process induced by ox‐LDL. Oppositely, inhibitors of miR‐328 strongly promoted ox‐LDL‐induced endothelial cells injury in HUVECs. By using bioinformatics analysis, high‐mobility group box‐1 (HMGB1) was predicted as a downstream target of miR‐328. HMGB1 has been reported to be involved in atherosclerosis development. The correlation between miR‐328 and HMGB1 was validated in our current study. Taken these together, it was implied that miR‐328 ameliorated ox‐LDL‐induced endothelial cells injury through targeting HMGB1 in atherosclerosis.

show abstract

“…Moreover, a growing body of recent data has shown that circulating miRs could influence the development and progression of vascular diseases, including atherosclerosis [24,25]. Although atherosclerosis is common in clinical practice, the mechanisms of its genesis have …”

Section: Discussionmentioning

confidence: 99%

Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis

Huang¹,

Li²,

Huang³

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Atherosclerosis is a serious disease that increases the risk of myocardial infarction and ischemic stroke. Previous studies have demonstrated that microRNA (miR)-29c could play significant roles in atherosclerosis via regulating inflammatory processes. However, the relationship between miR-29c and carotid intima-media thickness (CIMT) remains unknown. This study investigated associations between miR-29c and atherosclerosis and tested whether plasma miR-29c levels could be used to detect atherosclerosis. Methods: Plasma miR-29c levels were estimated by quantitative real-time PCR, and CIMT was measured by carotid ultrasound. Associations between miR-29c and CIMT were assessed by Spearman’s correlation coefficient and multiple linear regression analyses. Results: In total, 170 participants were divided into the study (CIMT ≥0.9 mm) and control (CIMT < 0.9 mm) groups. The study group showed higher C-reactive protein (CRP) and miR-29c relative expression levels compared with the control group. CIMT was positively correlated with miR-29c (r=0.659, p< 0.001) and CRP (r=0.447, p< 0.001), and miR-29c levels were also correlated with CRP (r=0.512, p< 0.001). Furthermore, multiple linear regression analysis showed that CIMT was significantly correlated with miR-29c (β=0.573, 95% confidence interval [CI]: 0.315-0.839; p< 0.001) and CRP (β=0.439, 95%CI: 0.186–0.825; p< 0.001). After age, body mass index, systolic blood pressure, total cholesterol and fasting blood-glucose were adjusted for, CIMT was still closely associated with miR-29c (β=0.529, 95%CI: 0.354–0.812; p< 0.001) and CRP (β=0.417, 95%CI: 0.198–0.724; p< 0.001). Evaluating CRP and miR-29c together (AUC=0.900, p< 0.001) achieved a better prognostic value for atherosclerosis than miR-29c (AUC=0.870, p< 0.001) or CRP (AUC=0.722, p< 0.001) alone. Conclusion: Increased miR-29c was closely associated with CIMT and may serve as a biomarker for identifying atherosclerotic patients.

show abstract

Mir-22-3p Inhibits Arterial Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia by Targeting HMGB1 in Arteriosclerosis Obliterans

Cited by 71 publications

References 46 publications

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

Emerging Role of High Mobility Group Box-1 in Thrombosis-Related Diseases

MicroRNA‐328 ameliorates oxidized low‐density lipoprotein‐induced endothelial cells injury through targeting HMGB1 in atherosclerosis

Plasma MicroRNA-29c Levels Are Associated with Carotid Intima-Media Thickness and is a Potential Biomarker for the Early Detection of Atherosclerosis

Contact Info

Product

Resources

About