MiR-23a promotes autophagy of yak cumulus cells to alleviate apoptosis via the apoptosis signal-regulating kinase 1/c-Jun N-terminal kinase pathway

Han, Xiaohong; Yu, Sijiu; Cui, Yan; Li, Jingjing; Fan, Jiangfeng; Wang, Libin; Wang, Meng; Pan, Yangyang; Xu, Gengquan

doi:10.1016/j.theriogenology.2023.08.018

Cited by 2 publications

(1 citation statement)

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“…Caenorhabditis elegans represses the expression of an autophagy regulator, Mucolipin 1 (CUP-5/MCOLN), with mir-83 expression levels increasing with age in the intestine, highlighting a role for this miRNA in coordinating macroautophagic events during the aging process 66 Similarly, MiR23a has been strongly linked to autophagy because it targets apoptosis signal-regulating kinase 1 (ASK-1), limiting the apoptosis of cumulus cells in yaks (Bos grunniens) 67 . Moreover, both MIR27a and MIR27b regulate mitochondrial autophagy by repressing the mRNA of PTEN-induced putative kinase 1 (PINK1) 68 , thereby preventing the PINK1 accumulation that occurs upon mitochondrial damage and curtailing mitophagic influx.…”

Section: Notably Extracellular Vesicle-encapsulated Mir-83 Inmentioning

confidence: 99%

Elucidation of how the Mir-23-27-24 cluster regulates development and aging

Yap,

Chen

2024

Exp Mol Med

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MicroRNAs (miRNAs) are pivotal regulators of gene expression and are involved in biological processes spanning from early developmental stages to the intricate process of aging. Extensive research has underscored the fundamental role of miRNAs in orchestrating eukaryotic development, with disruptions in miRNA biogenesis resulting in early lethality. Moreover, perturbations in miRNA function have been implicated in the aging process, particularly in model organisms such as nematodes and flies. miRNAs tend to be clustered in vertebrate genomes, finely modulating an array of biological pathways through clustering within a single transcript. Although extensive research of their developmental roles has been conducted, the potential implications of miRNA clusters in regulating aging remain largely unclear. In this review, we use the Mir-23-27-24 cluster as a paradigm, shedding light on the nuanced physiological functions of miRNA clusters during embryonic development and exploring their potential involvement in the aging process. Moreover, we advocate further research into the intricate interplay among miRNA clusters, particularly the Mir-23-27-24 cluster, in shaping the regulatory landscape of aging.

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Section: Notably Extracellular Vesicle-encapsulated Mir-83 Inmentioning

confidence: 99%