miR‑23b inhibits proliferation of SMMC‑7721 cells by directly targeting IL‑11

Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated mortality in the 21st century. microRNA (miR)-23b has been shown to be involved in the pathogenesis of many cancers, including breast and prostate cancer. However, the role of miR-23b in HCC remains unclear. The present study revealed a negative correlation between miR-23b expression in HCC tissues and progression of carcinomas. Compared to normal tissues, miR-23b expression was significantly downregulated in HCC tissues, whereas the expression of interleukin (IL)-11 and IL-11 receptor α (IL-11Rα) was significantly upregulated, indicating that miR-23b expression is negatively correlated with IL-11 and IL-11Rα expression. In addition, miR-23b inhibited proliferation and promoted apoptosis of SMMC-7721 cells. This effect was mediated by IL-11, which was found to be the direct target of miR-23b in this study. These results indicated that miR-23b regulates IL-11 and IL-11Rα expression, and might act as an anti-oncogenic agent in the progression of HCC by directly downregulating IL-11 expression.

Upregulation of microRNA-23b-3p induced by farnesoid X receptor regulates the proliferation and apoptosis of osteosarcoma cells

“…Growing studies have reported that miR-23b-3p functions as a predictor and prognostic molecular marker for different cancer types such as esophageal squamous cell carcinomas [17], pancreatic ductal adenocarcinoma [24], and HCC [15]. In our study, we found a positive correlation between miR-23b-3p and FXR and that GW4064 treatment could induce the upregulation of FXR and miR-23b-3p.…”

“…Importantly, studies suggested a high association between abnormal miRNA expressions and the development and progression of numerous cancer types [9–12]. MiR-23b-3p, one of the many in miRNA family, has been considered as a biomarker for assisting the diagnosis and prognosis of different types of cancers such as ovarian cancer [13], prostate cancer [14], and hepatocellular carcinoma (HCC) [15]. In 2018, Xian et al found that upregulating miR-23b-3p level could effectively inhibit gastric carcinoma cell proliferation, migration, and invasion through targeting cannabinoid receptor 1 (CB1R) [16].…”

Applying multi-omics data to study the genetic background of bovine respiratory disease infection in feedlot crossbred cattle

“…On the other hand, IL-5 is produced by CD4 + T-cells and causes B-cell growth factor and differentiation, IgA selection, eosinophil activation, and increased production of innate immune cells ( Akdis et al, 2011 ). This study also identified DE genes ( IL1R2 , IL1RAP , and IL12B ) related to interleukin-1 (IL-1) and interleukin-12 (IL-12) which cause lymphocyte activation, macrophage stimulation, increased leukocyte adhesion and release of acute phase proteins by the liver, or induced interferon gamma production by T-cells and natural killer cells ( Arena et al, 1998 ; Akdis et al, 2011 ; Dinarello, 2018 ; Jiang et al, 2018 ). It is worth noting that IL3RA and LRG1 have been reported to be associated with BRD in previous transcriptomic studies ( Tizioto et al, 2015 ; Scott et al, 2020 ; Jiminez et al, 2021 ).…”

Intersecting Paths: Unraveling the Complex Journey of Cancer to Bone Metastasis

“…Bone marrow stromal cells and fibroblasts generate IL-11, which primarily targets hematopoietic progenitors and osteoclasts. IL-11 functions include promoting osteoclast formation, increasing colony-stimulating factor levels, raising platelet count in vivo, and inhibiting the production of pro-inflammatory cytokines [87]. The synovial macrophages and T cells produce TNF-α, interleukin (IL)-1, IL-6, and IL-17 which enhance the osteoclastogenic process by acting on osteoblasts to promote RANKL expression [88].…”