miR‑24 may be a negative regulator of menin in lung cancer

Abstract

The incidence of lung cancer in China increases annually, and effective targets for the diagnosis and treatment of lung cancer are urgently needed. miRNAs are currently considered to be involved in the regulation of tumor development and growth. miR‑24 has been found to contribute to the development of several tumors. Menin is a key tumor suppressor gene, and its expression is generally low in lung cancer. The effects of miR‑24 on the biological behavior of lung cancer cells were detected by MTT and Transwell assays. In the present study, miR‑24 was found to be associated with menin, affecting the activity of the SMAD3 pathway in lung cancer by inhibiting menin expression. miR‑24 may promote the growth and metastasis and inhibit the apoptosis of lung cancer cells by targeting menin. Therefore, the aim of the present study was to provide a new theoretical basis for the targeted therapy of lung cancer.

MiR-24-3p and various cancers: From a meta-analysis view

“…The overall sample size is 1518 patients coming from 25 to 247 which from 4 countries. Among these studies, several types of cancer include lung cancer (n = 3) [33][34][35], hepatocellular carcinoma (n = 2) [36,37], colorectal cancer (n = 2) [29,38], nasopharyngeal carcinoma (n = 2) [39,40], osteosarcoma (n = 1) [41], ALL (n = 1) [42], AML (n = 1) [42], advanced gastric cancer (n = 1) [28], esophageal cancer (n = 1) [43], head and neck squamous cell carcinoma (n = 1) [44]. As for OS, RFS and DFS, there were seven studies directly provide HRs and its 95% CI [28,29,[35][36][37][38][39].…”

“…As for OS, RFS and DFS, there were seven studies directly provide HRs and its 95% CI [28,29,[35][36][37][38][39]. In addition, the remaining eight studies only provided Kaplan-Meier curves [28,33,34,[40][41][42][43][44]. All studies measured the miR-24-3p expression level by qRT-PCR (quantitative real-time polymerase chain reaction).…”

MicroRNA-24 in Cancer: A Double Side Medal With Opposite Properties

“…The up-regulation or down-regulation of miR-24 has been found in the specific cancer type. On the one hand, compared with normal tissues, miR-24 was found to be up-regulated in the following human cancers: lung cancer (LC) ( 6 , 44 , 45 ), hepatocellular carcinoma (HCC) ( 7 ), breast cancer (BC) ( 8 ), tongue squamous cell carcinoma (TSCC) ( 42 ), bladder cancer (BLC) ( 46 ), gastric cancer (GC) ( 47 ), acute leukemia (AL) ( 48 ), and Hodgkin Lymphoma (HL) ( 49 ). On the other hand, miR-24 was found to be down-regulated in the following human cancers: nasopharyngeal carcinoma (NPC) ( 9 ), colorectal cancer (CRC) ( 10 ), laryngeal squamous cell carcinoma (LSCC) ( 11 ), prostate cancer (PC) ( 27 , 28 ), lung adenocarcinoma (LA) ( 29 , 30 ), bladder cancer (BLC) ( 31 ), and gastric cancer (GC) ( 32 ), compared to the normal tissues.…”

“…On the other hand, miR-24 was found to be down-regulated in the following human cancers: nasopharyngeal carcinoma (NPC) ( 9 ), colorectal cancer (CRC) ( 10 ), laryngeal squamous cell carcinoma (LSCC) ( 11 ), prostate cancer (PC) ( 27 , 28 ), lung adenocarcinoma (LA) ( 29 , 30 ), bladder cancer (BLC) ( 31 ), and gastric cancer (GC) ( 32 ), compared to the normal tissues. Specifically, miR-24 promoted lung cancer progression by regulating the tumor suppressor gene menin ( 45 ). While miR-24 was downregulated in both lung adenocarcinoma tissues and cells, and it suppressed the proliferation and migration of LA cells by regulating fibroblast growth factor receptor 3 (FGFR3) ( 30 ).…”

“…And miR-24 increased cell metastasis and invasion by targeting p53 ( 7 ). In lung cancer, miR-24 promoted cancer cell growth and metastasis and inhibited cell apoptosis also by targeting menin, and SOX7 (sex-determining region Y-box 7) ( 44 , 45 ). In colorectal cancer, a study showed that HIF-1α (hypoxia inducible factor-1α)-induced miR-23a~27a~24 cluster could promote cancer progression via reprogramming its metabolism ( 66 ), suggesting miR-24 might be an onco-miR in CRC.…”