miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

Kim, SangYun; Kim, A Young; Lee, Hyun Woo; Son, You Hwa; Lee, Gha Young; Lee, Joowon; Lee, Yun Sok; Kim, Jae Bum

doi:10.1016/j.bbrc.2010.01.012

Cited by 389 publications

(332 citation statements)

References 39 publications

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“…[65][66][67] Adipogenic differentiation is stimulated by miR-143 68 and miR-204 69 whereas miR-21 and miR-27 have been shown to down-regulate adipogenesis by directly targeting the adipogenic transcription factor PPARG. 70,71 Recently, Bork and co-workers 72 have for the first time identified miR-369-5p and miR-371 as two additional adipogenic regulators. Adipogenic differentiation was significantly impaired by miR-369-5p, whereas it was enhanced by miR-371.…”

Section: Mirnas In the Hematopoietic Stem Cell Nichementioning

confidence: 99%

MicroRNAs are shaping the hematopoietic landscape

Bissels¹,

Bosio²,

Wagner³

2011

Haematologica

115

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Section: Mirnas In the Hematopoietic Stem Cell Nichementioning

confidence: 99%

MicroRNAs are shaping the hematopoietic landscape

Bissels¹,

Bosio²,

Wagner³

2011

Haematologica

115

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“…9 Collectively, these results suggest a strong involvement of miRNAs in the process of adipogenesis. In line with this, several in vitro studies have already revealed distinct miRNAs to steer murine adipocyte differentiation, 6,[10][11][12][13][14][15][16][17] while only a few studies did so for human. [18][19][20][21] We are interested in miRNAs with a regulatory role in adipocyte differentiation and function, particularly in human.…”

Section: Mir-30c Is Upregulated During Adipocyte Differentiationmentioning

confidence: 82%

MicroRNA-30c promotes human adipocyte differentiation and co-repressesPAI-1andALK2

Karbiener

Neuhold²,

Opriessnig³

et al. 2011

RNA Biology

120

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“…MiR-27a modulates the growth of breast and liver cancer cells by targeting FOXO1 and FZD7/β-catenin, respectively (Guttilla and White, 2009;Chen et al, 2013). Besides, miR-27a also suppresses adipocyte differentiation through targeting PPARγ (Kim et al, 2010). We previously demonstrated that miR-27a inhibits myostatin expression then promotes proliferation of C2C12 myoblasts (Huang et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

Yang

Chen

Huang

et al. 2014

Animal

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MicroRNAs are endogenous~22nt RNAs that negatively regulate gene expression at the posttranscriptional level via binding to the 3′-untranslated region (3′UTR) of target mRNAs. The microRNA miR-27a was reported to depress the expression of myostatin, a critical inhibitor of skeletal myogenesis, by binding to its 3′UTR in mouse. In this study, we cloned the full-length 3′UTR of porcine myostatin by rapid amplification of 3′-cDNA ends (3′-RACE) and demonstrated that the 3′UTR of porcine myostatin is targeted by miR-27a. The phenomenon that the level of myostatin inversely correlated with miR-27a was observed in fat and heart of pigs and also in proliferating porcine myoblasts. Besides, overexpression of miR-27a in porcine myoblasts promoted cell proliferation by reducing the expression of myostatin. Our data suggest that miR-27a positive regulates porcine myoblast proliferation via targeting myostatin.

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miR-27a is a negative regulator of adipocyte differentiation via suppressing PPARγ expression

Cited by 389 publications

References 39 publications

MicroRNAs are shaping the hematopoietic landscape

MicroRNAs are shaping the hematopoietic landscape

MicroRNA-30c promotes human adipocyte differentiation and co-repressesPAI-1andALK2

MicroRNA-27a promotes porcine myoblast proliferation by downregulating myostatin expression

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