miR-29b-3p Inhibitor Alleviates Hypomethylation-Related Aberrations Through a Feedback Loop Between miR-29b-3p and DNA Methylation in Cardiomyocytes

Wu, Fang; Yang, Qian; Mi, Yaping; Wang, Feng; Cai, Ke; Zhang, Yawen; Wang, Youhua; Wang, Xu; Gui, Yonghao; Li, Qiang

doi:10.3389/fcell.2022.788799

Cited by 2 publications

(2 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MiR-15a/miR-16-1 can interact with HDAC3 and HDAC9, which affects histone activity and the expression of cell cycle-related genes [346,348]. However, miR-29b interacts with DNMT3A and DNMT3B, affecting DNA methylation and the expression of key genes used in the cell cycle [317,346,349]. In colorectal cancer, miRNAs such as miR-449a have been implicated in cell cycle regulation through their interactions with histone-modifying enzymes.…”

Section: Functional Consequences Of Mirna-histone Enzyme Interplaymentioning

confidence: 99%

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Szczepanek,

Tretyn

2023

Biomolecules

View full text Add to dashboard Cite

In the past decade, significant advances in molecular research have provided a deeper understanding of the intricate regulatory mechanisms involved in carcinogenesis. MicroRNAs, short non-coding RNA sequences, exert substantial influence on gene expression by repressing translation or inducing mRNA degradation. In the context of cancer, miRNA dysregulation is prevalent and closely associated with various stages of carcinogenesis, including initiation, progression, and metastasis. One crucial aspect of the cancer phenotype is the activity of histone-modifying enzymes that govern chromatin accessibility for transcription factors, thus impacting gene expression. Recent studies have revealed that miRNAs play a significant role in modulating these histone-modifying enzymes, leading to significant implications for genes related to proliferation, differentiation, and apoptosis in cancer cells. This article provides an overview of current research on the mechanisms by which miRNAs regulate the activity of histone-modifying enzymes in the context of cancer. Both direct and indirect mechanisms through which miRNAs influence enzyme expression are discussed. Additionally, potential therapeutic implications arising from miRNA manipulation to selectively impact histone-modifying enzyme activity are presented. The insights from this analysis hold significant therapeutic promise, suggesting the utility of miRNAs as tools for the precise regulation of chromatin-related processes and gene expression. A contemporary focus on molecular regulatory mechanisms opens therapeutic pathways that can effectively influence the control of tumor cell growth and dissemination.

show abstract

Section: Functional Consequences Of Mirna-histone Enzyme Interplaymentioning

confidence: 99%

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Szczepanek,

Tretyn

2023

Biomolecules

View full text Add to dashboard Cite

show abstract

“…For instance, DNA methyltransferases and the miR-29b-3p levels were negatively correlated in the CHD patients [ 238 ]. For cardiac cell proliferation and cardiac abnormalities, certain miRNAs (hsa-miR-221-3p, hsa-miR-218-5p, and hsa-miR-873-5p) have been described in [ 239 ].…”

Section: Micrornas (Mirnas)mentioning

confidence: 99%

Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review

Zare

Salehpour

Khoradmehr

et al. 2023

Life

View full text Add to dashboard Cite

More research is being conducted on myocardial cell treatments utilizing stem cell lines that can develop into cardiomyocytes. All of the forms of cardiac illnesses have shown to be quite amenable to treatments using embryonic (ESCs) and induced pluripotent stem cells (iPSCs). In the present study, we reviewed the differentiation of these cell types into cardiomyocytes from an epigenetic standpoint. We also provided a miRNA network that is devoted to the epigenetic commitment of stem cells toward cardiomyocyte cells and related diseases, such as congenital heart defects, comprehensively. Histone acetylation, methylation, DNA alterations, N6-methyladenosine (m6a) RNA methylation, and cardiac mitochondrial mutations are explored as potential tools for precise stem cell differentiation.

show abstract

miR-29b-3p Inhibitor Alleviates Hypomethylation-Related Aberrations Through a Feedback Loop Between miR-29b-3p and DNA Methylation in Cardiomyocytes

Cited by 2 publications

References 54 publications

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications

Epigenetic Modification Factors and microRNAs Network Associated with Differentiation of Embryonic Stem Cells and Induced Pluripotent Stem Cells toward Cardiomyocytes: A Review

Contact Info

Product

Resources

About