miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

Zhou, Fangwei; Liu, Peiqiang; Lv, Hao; Gao, Ziang; Chang, Wenchuan; Xu, Yu

doi:10.3892/mmr.2020.11680

Cited by 11 publications

(12 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…pneumoniae infections in the lungs with the onset of asthma and wheezing [ 10 ]. One of the underlying causes of asthma and inflammatory responses of respiratory infection are induced by Th-2-type cytokines such as IL-4 and IL-13 [ 11 ]. These cytokines alerts the IL-4Rα/IL-13Rα1 receptor of the signal transducer and activator of transcription 6 (STAT6) thereby promoting inflammation, mucus-secreting cell (MSC) metaplasia/hyperplasia, and airway hyper responsiveness (AHR).…”

Section: Introductionmentioning

confidence: 99%

Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-LifeChlamydiaInfection

Wang

et al. 2021

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

Chlamydia (Ch) species are a type of pathogenic gram-negative bacteria that cause various respiratory tract infections including pharyngitis, bronchitis, and pneumonia [1]. They are obligate intracellular parasites and their infection also causes bacterial sexually transmitted diseases among humans [2]. The most common species of Chlamydia are Ch. pneumonia, Ch. abortus, Ch. psittaci, Ch. trachomatis (which infects humans), Ch. muridarum (which only infects rodents and mice) and Ch. suis (which infects swine) [3]. The species infect humans and cause respiratory infection by rupturing the lining of the respiratory tract including the throat, lungs and windpipe [4]. Most people get infected with Ch. pneumoniae and may have mild symptoms or no symptoms at all [5]. In most cases Ch. Pneumonia infections occur for the first time during school days or young age [6]. The common symptoms of this bacterial infection are sore throat, runny nose, fatigue, mild fever, and headache [7]. Respiratory infections caused by Ch. pneumoniae are common during early life and many teenagers who showed asymptomatic symptoms are the root cause of of community-acquired pneumonia, particularly among the newborn and pediatric population [8]. On the other hand, the cytokine interleukin 4 (IL-4) plays a major role in the induction and differentiation of naive helper T-helper cells from Th0 to Th2 cells. IL-4 is mainly produced by mast cells, basophils, and eosinophils, and when it is activated, the Th2 cell generates extra . The function of IL-4 is quite similar to that of IL-13 and both of them are closely associated. IL-4 is known to play a crucial role the pathogenesis of asthma and other inflammatory responses arising from respiratory infection. There are also reports which link the association of Ch. pneumoniae infections in the lungs with the onset of asthma and wheezing [10]. One of the underlying causes of asthma and inflammatory responses of respiratory infection are induced by Th-2-type cytokines such as IL-4 and IL-13 [11]. These cytokines alerts the IL-4Rα/IL-13Rα1 receptor of the signal transducer and activator of transcription 6 (STAT6) thereby promoting inflammation, mucussecreting cell (MSC) metaplasia/hyperplasia, and airway hyper responsiveness (AHR). In spite of these reports, the underlying mechanism of IL-4 is not properly understood with respect to respiratory infection [12,13]. It also Chlamydia pneumoniae is a type of pathogenic gram-negative bacteria that causes various respiratory tract infections including asthma. Chlamydia species infect humans and cause respiratory infection by rupturing the lining of the respiratory which includes the throat, lungs and windpipe. Meanwhile, the function of interleukin-4 (IL-4) in Ch. pneumoniae respiratory infection and its association with the development of airway hyperresponsiveness (AHR) in adulthood and causing allergic airway disease (AAD) are not understood properly. We therefore investigated the role of IL-4 in respiratory infection and allergy caused by early life Chlamyd...

show abstract

Section: Introductionmentioning

confidence: 99%

Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-LifeChlamydiaInfection

Wang

et al. 2021

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…In this study, we did not specifically explore what cells were infected by lentivirus and produced miR-181a-5p. According to a large number of references [60][61][62][63][64][65], which reported that nasal epithelial cells are the barrier to resist the invasion of external pathogens, which can carry out plasma, siRNA, and miR-NA transduction, regulate the inflammatory response of nasal epithelial cells, and play a major role in AR. Therefore, we speculate that miR-181a-5p may be produced by nasal epithelial cells infected by lentivirus.…”

Section: Discussionmentioning

confidence: 99%

Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

Chen

et al. 2021

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Introduction: Allergic rhinitis (AR) is an immune disorder and also a risk factor of asthma. microRNAs (miRNAs) are implicated in autoimmune diseases, including RA. This study investigated effect of miR-181a-5p on regulatory T (Treg)/ T-helper (Th) 17 immune imbalance in AR. Methods: A murine model of AR was established and treated with lentivirus modified miR-181a-5p. The allergic symptoms of mice were examined. The contents of Th17-related cytokines (interferon [IFN]-γ and interleukin [IL]-6), Treg-related cytokine (IL-10), and Treg-specific nuclear transcription factor (Foxp3) in nasal mucosa and lung tissues were determined. The proportion of Treg and Th17 cells was analyzed by flow cytometry. The level of ovalbumin-specific immunoglobulin E in the serum, and the contents of IL-4, IL-5, and IL-13 in bronchoalveolar lavage fluid and IFN-γ, IL-6, and IL-10 in nasal lavage fluid were measured. The targeting relationship between miR-181a-5p and high mobility group box chromosomal protein 1 (HMGB1) was verified. HMGB1 and receptor for advanced glycation end products (RAGE) expression in RA were determined, and the interaction between HMGB1 and RAGE was detected. Results: miR-181a-5p expression was reduced in AR mice. miR-181a-5p overexpression attenuated allergic behaviors, alleviated Treg/Th17 imbalance, and delayed asthma development. HMGB1 and RAGE were elevated in AR mice. miR-181a-5p targeted HMGB1, and HMGB1 bound to RAGE, while miR-181a-5p overexpression reduced the binding between them. Activating HMGB1/RAGE reversed the protective effect of miR-181a-5p overexpression on AR and induced the development of asthma. Conclusion: miR-181a-5p overexpression reduced the binding of HMGB1 and RAGE by inhibiting HMGB1, thus alleviating Treg/Th17 immune imbalance and blocking AR from developing into asthma.

show abstract

“…Some miRNAs can directly target the 3′-UTR of these molecules as a result of miR-17-3p (targeting ICAM-1) and miR-31 (targeting E-selectin), which are connected to coronary atherosclerosis [ 49 ]. These molecules induce an increase in macrophages in the process of atherosclerosis [ 50 , 51 , 52 ]. It is unclear how these two miRNAs function in experimental coronary atherosclerosis.…”

Section: Gene and Protein Markersmentioning

confidence: 99%

New Progress in Early Diagnosis of Atherosclerosis

Meng

Ruan

Yan

et al. 2022

IJMS

View full text Add to dashboard Cite

Coronary atherosclerosis is a potentially chronic circulatory condition that endangers human health. The biological cause underpinning cardiovascular disease is coronary atherosclerosis, and acute cardiovascular events can develop due to thrombosis, platelet aggregation, and unstable atherosclerotic plaque rupture. Coronary atherosclerosis is progressive, and three specific changes appear, with fat spots and stripes, atherosclerosis and thin-walled fiber atherosclerosis, and then complex changes in arteries. The progression and severity of cardiovascular disease are correlated with various levels of calcium accumulation in the coronary artery. The therapy and diagnosis of coronary atherosclerosis benefit from the initial assessment of the size and degree of calcification. This article will discuss the new progress in the early diagnosis of coronary atherosclerosis in terms of three aspects: imaging, gene and protein markers, and trace elements. This study intends to present the latest methods for diagnosing patients with early atherosclerosis through a literature review.

show abstract

miR-31 attenuates murine allergic rhinitis by suppressing interleukin-13-induced nasal epithelial inflammatory responses

Cited by 11 publications

References 42 publications

Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-LifeChlamydiaInfection

Role of Interleukin-4 (IL-4) in Respiratory Infection and Allergy Caused by Early-LifeChlamydiaInfection

Mechanism of miR-181a-5p in Regulatory T/T-Helper 17 Immune Imbalance and Asthma Development in Mice with Allergic Rhinitis

New Progress in Early Diagnosis of Atherosclerosis

Contact Info

Product

Resources

About