miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1

Wu, Yihui; Huang, Yu-Fang; Chang, Tzu-Hao; Wu, Pei‐Ying; Hsieh, Tsung-Ying; Hsiao, Sheng-Yen; Huang, Soon-Cen; Chou, Cheng‐Yang

doi:10.3390/cancers13246257

Cited by 16 publications

(11 citation statements)

References 48 publications

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“…It affects cancer progression by regulating several downstream genes involved in biological processes such as cell proliferation, apoptosis, metastasis, and signal transduction. [ 15 ] COL11A1 overexpression has been observed in many cancer types. [ 16 ] Studies have shown that COL11A1 is highly expressed in patients with gastric cancer, which may be a potential therapeutic target.…”

Section: Discussionmentioning

confidence: 99%

COL11A1 as a potential prognostic target for oral squamous cell carcinoma

Di¹,

Bao²,

Guo³

et al. 2022

Medicine

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Oral squamous cell carcinoma (OSCC) is a malignant tumor occurring in the oral cavity. However, the molecular mechanism of OSCC is not clear. Bioinformatics was used to screen and identify role of collagen type X1 alpha 1 (COL11A1) on OSCC. 200 patients with OSCC were recruited. Clinical and follow-up data were recorded and COL11A1 expression levels were tested. Pearson chi-square test and Spearman correlation coefficient were used to analyze relationship between prognosis and related parameters in patients with OSCC. Univariate and multivariate Logistic regression, univariate and multivariate Cox proportional risk regression were used for further analysis, survival curve was drawn. Through bioinformatics analysis, OSCC patients with higher expression of COL11A1 have poor overall survival compare with OSCC patients with lower expression of COL11A1 (hazard ratios [HR] = 1.32, P = .047). Pearson chi-square test showed that age (P = .011), tumor grade (P = .023), COL11A1 (P < .001) was significantly correlated with prognosis of OSCC. Univariate Logistic regression analysis showed age (odds ratio [OR] = 2.102, 95% confidence intervals [95%CI]: 1.180-3.746, P = .012), tumor grade (OR = 1.919, 95%CI: 1.093-3.372, P = .023) and COL11A1 (OR = 12.775, 95%CI: 6.509-25.071, P < .001). Multivariate Logistic regression analysis showed that COL11A1 (OR = 12.066, 95%CI: 6.042-24.096, P < .001) was significantly associated with prognosis of patients with OSCC. Univariate Cox regression analysis showed that age (HR = 1.592, 95%CI: 1.150-2.205, P = .005), tumor grade (HR = 1.460, 95%CI: 1.067-1.999, P = .018) and COL11A1 (HR = 1.848, 95%CI: 1.340-2.548, P < .001) were significantly correlated with survival time of OSCC patients. Multivariate Cox regression analysis showed that tumor grade (HR = 1.466, 95%CI: 1.064-2.020, P = .019) and COL11A1 (HR = 1.645, 95%CI: 1.164-2.325, P = .005) were significantly correlated with survival time of OSCC patients. COL11A1 is significantly correlated with occurrence of OSCC. When COL11A1 is highly expressed, prognosis of patients with OSCC is worse and the survival time is shorter.Abbreviations: 95%CI = 95% confidence intervals, COL11A1 = collagen type X1 alpha 1, DEGs = differently expressed genes, GO = gene body, GSEA = gene set enrichment analysis, HRs = hazard ratios, OR = odds ratio, OSCC = oral squamous cell carcinoma, SVM = support vector machine.

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Section: Discussionmentioning

confidence: 99%

COL11A1 as a potential prognostic target for oral squamous cell carcinoma

Di¹,

Bao²,

Guo³

et al. 2022

Medicine

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“…Furthermore, patients with low miR335 levels were susceptible to advanced-stage cancer, poor response to chemotherapy, and early relapse. These findings highlighted the importance of miR-335 in downregulating COL11A1-mediated ovarian tumor progression, chemoresistance, and poor survival and suggested the potential application of miR-335 as a therapeutic target ( 37 ). Kang et al.…”

Section: Regulation Of Col11a1 In Human Cancermentioning

confidence: 92%

“…We ( 37 ) identified miR-335 as the candidate miRNAs that may regulate COL11A1 expression through an online database search. Further mechanistic experiments revealed that epithelial ovarian cancer (EOC) cell treatment with miR-335 results in phenotypes that mimic those induced by abrogated COL11A1 expression and suppresses cell proliferation and invasion, in addition to increasing the sensitivity of EOC cells to cisplatin.…”

Section: Regulation Of Col11a1 In Human Cancermentioning

confidence: 99%

Collagen XI Alpha 1 Chain, a Novel Therapeutic Target for Cancer Treatment

Chou

2022

Front. Oncol.

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The extracellular matrix (ECM) plays an important role in the progression of cancer. Collagen is the most abundant component in ECM, and is involved in the biological formation of cancer. Although type XI collagen is a minor fibrillar collagen, collagen XI alpha 1 chain (COL11A1) expression has been found to be upregulated in a variety of human cancers including colorectal, esophagus, glioma, gastric, head and neck, lung, ovarian, pancreatic, salivary gland, and renal cancers. High levels of COL11A1 usually predict poor prognosis, owing to its association with angiogenesis, invasion, and drug resistance in cancer. However, little is known about the specific mechanism through which COL11A1 regulates tumor progression. Here, we have organized and summarized recent developments regarding the interactions between COL11A1 and intracellular signaling pathways and selected therapeutic agents targeting COL11A1, as these indicate its potential as a target for treatment of cancers, especially epithelial ovarian cancer.

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“…It can assist chemotherapy agents in forming a pro-oxidant effect so that cancer cells increase and cell proliferation can be inhibited [3]. Flavonoids are one of the antioxidants that play a role in inhibiting cancer cells by binding to the death receptor (TNF-R) and Fas-associated Death Domain (FADD), which form the Death Inducing Signaling Complex (DISC) [17][18][19][20][21].…”

Section: Cytotoxic Activity Testmentioning

confidence: 99%

Cytotoxicity activity of ethanol extract of mentangor stem skin (Calophyllum rufigemmatum) against breast cancer cells MCF-7 in vitro

et al. 2023

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Cancer is one of the non-communicable diseases that causes the most death in Indonesia. In a study conducted by researchers from Northwestern University on 686 breast cancer patients, 36% of women chose to stop their treatment because they could not tolerate the side effects of the drug. The patient's side effects were joint pain, hot flashes, increased weight gain, and nausea. Mentangor plant (Calophyllum rufigemmatum) is a plant that grows a lot in Bangka Belitung and has been used by the people of Bangka Belitung as a traditional medicine to treat skin diseases. Research on the bark of the mentangor stem from Bangka Belitung has never been carried out regarding its phytochemical content and potential as an anticancer breast. For this reason, it is necessary to know breast cancer's pharmacological effects and phytochemicals on Mentangor Bangka Belitung's stem bark. Phytochemical identification was carried out qualitatively by observing changes in the test sample. Based on the results of phytochemical screening, several reactions showed that each test of the ethanol extract of the stem bark of Mentangor contained tannins, phenolics, flavonoids, and alkaloids. The measurement results of the IC50 value of inhibition of the proliferation ethanol extract with a diameter of 1 cm, 7 cm, and 17 cm against MCF-7 breast cancer cells were 326,195 g/mL, respectively; 186.178 g/mL; and 178.090 g/mL.

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miR-335 Restrains the Aggressive Phenotypes of Ovarian Cancer Cells by Inhibiting COL11A1

Cited by 16 publications

References 48 publications

COL11A1 as a potential prognostic target for oral squamous cell carcinoma

COL11A1 as a potential prognostic target for oral squamous cell carcinoma

Collagen XI Alpha 1 Chain, a Novel Therapeutic Target for Cancer Treatment

Cytotoxicity activity of ethanol extract of mentangor stem skin (Calophyllum rufigemmatum) against breast cancer cells MCF-7 in vitro

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