2022
DOI: 10.21203/rs.3.rs-2039595/v1
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miR-34a/DRP-1-mediated mitophagy participated in cisplatin-induced ototoxicity via increasing oxidative stress

Abstract: Purpose Cisplatin is a widely and effectively chemotherapy agent for most of solid malignant tumors. However,cisplatin induced ototoxicity is a common adverse effect,which limited the therapeutic efficacy of tumors in clinic.To date,the specific mechanism of ototoxicity is not fully elucidated and the management of cisplatin-induced ototoxicity also is an urgent challenge.Recently,some authors believed that miR34a and mitophagy played a role in age-related and drug-induced hearing loss.Our study is aimed at ex… Show more

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