MiR-34a functions as a tumor suppressor in oral cancer through the inhibition of the Axl/Akt/GSK-3β pathway

Su, Yu-Fu; Lin, Chun-Shu; Shen, Po-Chien; Chuang, Shuang-En; Dai, Yang-Hong; Huang, Tsai-Wang; Lin, Che-Yi; Hung, Yi-Jen; Shieh, Yi-Shing

doi:10.1016/j.jds.2023.08.013

Cited by 2 publications

(1 citation statement)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Research is still ongoing to improve the accessibility of miR-34 family members in translational research and clinical practice in respect to the treatment of breast cancer [41], colon cancer [42], lung cancer [43], oral cancer [44], oesophageal cancer [45] and some others (reviewed in [46]).…”

Section: Functions Of Small Non-coding Rnas and Their Modulation By E...mentioning

confidence: 99%

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Štefánik,

Morová,

Herichová

2024

Biomedicines

View full text Add to dashboard Cite

The present review focuses on the interactions of newly emerging environmental factors with miRNA-mediated regulation. In particular, we draw attention to the effects of phthalates, electromagnetic fields (EMFs) and a disrupted light/dark cycle. miRNAs are small non-coding RNA molecules with a tremendous regulatory impact, which is usually executed via gene expression inhibition. To address the capacity of environmental factors to influence miRNA-mediated regulation, the miR-34 family was selected for its well-described oncostatic and neuro-modulatory properties. The expression of miR-34 is in a tissue-dependent manner to some extent under the control of the circadian system. There is experimental evidence implicating that phthalates, EMFs and the circadian system interact with the miR-34 family, in both lines of its physiological functioning. The inhibition of miR-34 expression in response to phthalates, EMFs and light contamination has been described in cancer tissue and cell lines and was associated with a decline in oncostatic miR-34a signalling (decrease in p21 expression) and a promotion of tumorigenesis (increases in Noth1, cyclin D1 and cry1 expressions). The effects of miR-34 on neural functions have also been influenced by phthalates, EMFs and a disrupted light/dark cycle. Environmental factors shifted the effects of miR-34 from beneficial to the promotion of neurodegeneration and decreased cognition. Moreover, the apoptogenic capacity of miR-34 induced via phthalate administration in the testes has been shown to negatively influence germ cell proliferation. To conclude, as the oncostatic and positive neuromodulatory functions of the miR-34 family can be strongly influenced by environmental factors, their interactions should be taken into consideration in translational medicine.

show abstract

Section: Functions Of Small Non-coding Rnas and Their Modulation By E...mentioning

confidence: 99%

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Štefánik,

Morová,

Herichová

2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Theranostic potential of miRNAs in oral cancer: An emerging approach for precision oncology

Biju,

Veeraraghavan,

Francis

2024

Oral Science International

View full text Add to dashboard Cite

MicroRNAs (miRNAs) have emerged as pivotal regulators in the pathogenesis of oral cancer, offering promising diagnostic and therapeutic opportunities in precision oncology. Dysregulated miRNA expression profiles are reliable biomarkers for oral cancer diagnosis and prognosis. Specific miRNAs, including miR‐21, miR‐31, miR‐375, miR‐let‐7a, miR‐125a, and miR‐200c, show altered expression patterns linked to oral cancer diagnosis, staging, and prognosis. Furthermore, these differentially expressed miRNAs can be detected in readily available biofluids such as saliva and plasma, improving their utility as non‐invasive diagnostic tools. Aberrant miRNA expression contributes to crucial oncogenic pathways in oral cancer progression, metastasis, and drug resistance. Using miRNA mimics or anti‐miRNAs to manipulate miRNA expression provides a mechanism for influencing downstream target genes and sensitizing cancer cells to conventional chemotherapy or targeted therapies. Preclinical studies have demonstrated the efficiency of miRNA‐based therapeutics in suppressing the development of oral cancer cells and triggering apoptosis. Furthermore, miRNAs have been linked to medication resistance, opening up new options for improving therapy response in patients with oral cancer. Further research and clinical validation are warranted to fully exploit the theranostic potential of miRNAs in oral cancer management and advance precision oncology.

show abstract

MiR-34a functions as a tumor suppressor in oral cancer through the inhibition of the Axl/Akt/GSK-3β pathway

Cited by 2 publications

References 28 publications

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Impact of Long-Lasting Environmental Factors on Regulation Mediated by the miR-34 Family

Theranostic potential of miRNAs in oral cancer: An emerging approach for precision oncology

Contact Info

Product

Resources

About