MiR-3677-3p promotes development and sorafenib resistance of hepatitis B-related hepatocellular carcinoma by inhibiting FOXM1 ubiquitination

He, Hengzheng; Zhou, Jian; Cheng, Fahui; Li, H.; Quan, Yingyao

doi:10.1007/s13577-023-00945-z

Cited by 7 publications

(3 citation statements)

References 35 publications

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“…Our results are in line with mechanistical evidence. Of the five up-regulated/negatively prognostic miRNAs, four have been shown to act as oncogenes in HCC cells: mir-501 by promoting epithelial to mesenchymal transition [ 22 ]; mir-3127 and mir-1180 by promoting proliferation and tumorigenesis [ 23 , 24 ]; mir-3677 by promoting proliferation and drug resistance [ 25 ]. While the clinical significance of some of these transcripts has been described, to the best of our knowledge this is the first study showing that mir-3127 has a prognostic impact on HCC.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Smith,

Beach,

Silva

et al. 2024

PLoS ONE

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Robust prognostic and predictive factors for hepatocellular carcinoma, a leading cause of cancer-related deaths worldwide, have not yet been identified. Previous studies have identified potential HCC determinants such as genetic mutations, epigenetic alterations, and pathway dysregulation. However, the clinical significance of these molecular alterations remains elusive. MicroRNAs are major regulators of protein expression. MiRNA functions are frequently altered in cancer. In this study, we aimed to explore the prognostic value of differentially expressed miRNAs in HCC, to elucidate their associated pathways and their impact on treatment response. To this aim, bioinformatics techniques and clinical dataset analyses were employed to identify differentially expressed miRNAs in HCC compared to normal hepatic tissue. We validated known associations and identified a novel miRNA signature with potential prognostic significance. Our comprehensive analysis identified new miRNA-targeted pathways and showed that some of these protein coding genes predict HCC patients’ response to the tyrosine kinase inhibitor sorafenib.

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Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Smith,

Beach,

Silva

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Our results are in line with mechanistical evidence. Of the five up-regulated/negatively prognostic miRNAs, four have been shown to act as oncogenes in HCC cells: mir-501 by promoting epithelial to mesenchymal transition (20); mir-3127 and mir-1180 by promoting proliferation and tumorigenesis (21), (22); mir-3677 by promoting proliferation and drug resistance (23). Notably, our pathway analysis has identified cell cycle regulation as the main molecular pathway controlled by these miRNAs, further confirming the link between bioinformatic and experimental findings.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of differentially expressed miRNAs in Hepatocellular carcinoma: prognostic significance and pathway insights

Smith,

Beach,

Silva

et al. 2023

Preprint

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Robust prognostic and predictive factors for hepatocellular carcinoma, a leading cause of cancer-related deaths worldwide, have not yet been identified. Previous studies have identified potential HCC determinants such as genetic mutations, epigenetic alterations, and pathway dysregulation. However the clinical significance of these molecular alterations remains elusive. MicroRNAs are major regulators of protein expression. MiRNA functions are frequently altered in cancer. In this study, we aimed to explore the prognostic value of differentially expressed miRNAs in HCC and elucidate their associated pathways. To this aim, bioinformatics techniques and clinical dataset analyses were employed to identify differentially expressed miRNAs in HCC compared to normal hepatic tissue. We validated known associations and identified novel miRNAs with potential prognostic significance and proposed new targeting pathways based on our comprehensive analysis.

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“…Notably, there is an increased risk of severe autoimmunity without adequate regulation by Tregs. Other mechanisms to sensitize HBV-associated HCC to sorafenib-induced apoptosis include modulation of miRNA such as miR-193b and miR-3677-3p, in addition to inhibiting pro-oncogenic Mitogen-Activated Protein Kinase 14 (pMAPK14) [118][119][120].…”

Section: Persistent Risk Of Hcc In Hbv Infectionmentioning

confidence: 99%

Review of Related Factors for Persistent Risk of Hepatitis B Virus-Associated Hepatocellular Carcinoma

Varghese,

Majeed,

Nyalakonda

et al. 2024

Cancers

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Chronic hepatitis B virus (HBV) infection is the largest global cause of hepatocellular carcinoma (HCC). Current HBV treatment options include pegylated interferon-alpha and nucleos(t)ide analogues (NAs), which have been shown to be effective in reducing HBV DNA levels to become undetectable. However, the literature has shown that some patients have persistent risk of developing HCC. The mechanism in which this occurs has not been fully elucidated. However, it has been discovered that HBV’s covalently closed circular DNA (cccDNA) integrates into the critical HCC driver genes in hepatocytes upon initial infection; additionally, these are not targets of current NA therapies. Some studies suggest that HBV undergoes compartmentalization in peripheral blood mononuclear cells that serve as a sanctuary for replication during antiviral therapy. The aim of this review is to expand on how patients with HBV may develop HCC despite years of HBV viral suppression and carry worse prognosis than treatment-naive HBV patients who develop HCC. Furthermore, HCC recurrence after initial surgical or locoregional treatment in this setting may cause carcinogenic cells to behave more aggressively during treatment. Curative novel therapies which target the life cycle of HBV, modulate host immune response, and inhibit HBV RNA translation are being investigated.

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MiR-3677-3p promotes development and sorafenib resistance of hepatitis B-related hepatocellular carcinoma by inhibiting FOXM1 ubiquitination

Cited by 7 publications

References 35 publications

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Comprehensive analysis of differentially expressed miRNAs in hepatocellular carcinoma: Prognostic, predictive significance and pathway insights

Comprehensive analysis of differentially expressed miRNAs in Hepatocellular carcinoma: prognostic significance and pathway insights

Review of Related Factors for Persistent Risk of Hepatitis B Virus-Associated Hepatocellular Carcinoma

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