miR-372 promotes breast cancer cell proliferation by directly targeting LATS2

Cheng, Xueyuan; Chen, Junqiang; Huang, Zhong

doi:10.3892/etm.2018.5761

Cited by 31 publications

(26 citation statements)

References 38 publications

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“…miRNAs function as either oncogenes or tumor suppressors, playing crucial roles in tumorigenesis, tumor invasion and metastasis 5 . In recent years multiple studies have revealed the altered expression of miRNAs which play a role in the development and progression of diverse cancers including oral squamous cell carcinoma 6 – 8 . Increased expression of microRNAs including miR-155 and miR-23a, have been observed in oral cancer patients that are tobacco chewers compared to non-chewers 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes

Bhat

Advani

Rajagopalan

et al. 2018

Sci Rep

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Carcinogenic effect of tobacco in oral cancer is through chewing and/or smoking. Significant differences exist in development of oral cancer between tobacco users and non-users. However, molecular alterations induced by different forms of tobacco are yet to be fully elucidated. We developed cellular models of chronic exposure to chewing tobacco and cigarette smoke using immortalized oral keratinocytes. Chronic exposure to tobacco resulted in increased cell scattering and invasiveness in immortalized oral keratinocytes. miRNA sequencing using Illumina HiSeq 2500 resulted in the identification of 10 significantly dysregulated miRNAs (4 fold; p ≤ 0.05) in chewing tobacco treated cells and 6 in cigarette smoke exposed cells. We integrated this data with global proteomic data and identified 36 protein targets that showed inverse expression pattern in chewing tobacco treated cells and 16 protein targets that showed inverse expression in smoke exposed cells. In addition, we identified 6 novel miRNAs in chewing tobacco treated cells and 18 novel miRNAs in smoke exposed cells. Integrative analysis of dysregulated miRNAs and their targets indicates that signaling mechanisms leading to oncogenic transformation are distinct between both forms of tobacco. Our study demonstrates alterations in miRNA expression in oral cells in response to two frequently used forms of tobacco.

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Section: Introductionmentioning

confidence: 99%

Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes

Bhat

Advani

Rajagopalan

et al. 2018

Sci Rep

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show abstract

“…miRNAs are reported to be widely involved in multiple biological processes, including cellular proliferation, differentiation, migration and invasion, primarily through binding the 3′-untranslated region (3′UTR) of target mRNAs, inhibiting their translation ( 7 – 9 ). The altered expression of miRNAs was found to be associated with the progression of various tumors, including pancreatic, lung and breast cancer ( 10 – 12 ). miR-25-3p was reported to target Sema4C in CC cells thereby regulating the epithelial-mesenchymal transition ( 1 ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1

Dong

Wang

et al. 2018

Oncol Lett

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The abnormal expression of microRNAs (miRNAs/miRs) has been widely reported in various tumor types. miR-217 was demonstrated to be aberrantly expressed in a number of tumors, including pancreatic adenocarcinoma and osteosarcoma; however, its specific expression pattern has never been investigated in cervical cancer cells. Compared with normal control, the level of Rho-associated protein kinase 1 (ROCK1) expression was markedly increased in cervical cancer tissues and cells compared with that in non-cancerous tissues and cells. The expression of miR-217 was significantly reduced in cervical cancer tissues and cell lines. Overexpression of miR-217 could suppress colony formation and the cell invasion capacity of SiHa and HeLa cells. Flow cytometry indicated that miR-217 significantly increased cell apoptosis in SiHa and HeLa cells. Dual-luciferase reporter assays demonstrated that ROCK1 was a target gene of miR-217. In addition, overexpression of ROCK1 also led to an increased invasion capacity in SiHa cells, even when miR-217 was inhibited, indicating that the anti-invasive effects of miR-217 were mediated through ROCK1. In summary, the results of the present study indicated that miR-217 functions as a tumor suppressor in cervical cancer cells, primarily by targeting ROCK1.

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“…Our results are supported by third-party annotations in two databases, HMDD3.2 and dbDEMC. For example, miR-150 and miR-372 can promote the proliferation and growth of Breast Neoplasms cells by targeting the pro-apoptotic purinergic P2X7 receptor and LATS2 respectively (Huang et al, 2017;Cheng et al, 2018). MicroRNA-130a targets RAB5A to inhibit the proliferation, invasion and migration of Breast Neoplasms cells (Pan et al, 2015).…”

Section: Case Studymentioning

confidence: 99%

QIMCMDA: MiRNA-Disease Association Prediction by q-Kernel Information and Matrix Completion

et al. 2020

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Studies have shown that microRNAs (miRNAs) are closely associated with many human diseases, but we have not yet fully understand the role and potential molecular mechanisms of miRNAs in the process of disease development. However, ordinary biological experiments often require higher costs, and computational methods can be used to quickly and effectively predict the potential miRNA-disease association effect at a lower cost, and can be used as a useful reference for experimental methods. For miRNA-disease association prediction, we have proposed a new method called Matrix completion algorithm based on q-kernel information (QIMCMDA). We use fivefold crossvalidation and leave-one-out cross-validation to prove the effectiveness of QIMCMDA. LOOCV shows that AUC can reach 0.9235, and its performance is significantly better than other commonly used technologies. In addition, we applied QIMCMDA to case studies of three human diseases, and the results show that our method performs well in inferring potential interaction between miRNAs and diseases. It is expected that QIMCMDA will become an excellent supplement in the field of biomedical research in the future.

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miR-372 promotes breast cancer cell proliferation by directly targeting LATS2

Cited by 31 publications

References 38 publications

Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes

Cigarette smoke and chewing tobacco alter expression of different sets of miRNAs in oral keratinocytes

MicroRNA‑217 functions as a tumor suppressor in cervical cancer cells through targeting Rho‑associated protein kinase 1

QIMCMDA: MiRNA-Disease Association Prediction by q-Kernel Information and Matrix Completion

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