2020
DOI: 10.1007/s10620-020-06202-9
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MiR-375 Impairs the Invasive Capabilities of Hepatoma Cells by Targeting HIF1α Under Hypoxia

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Cited by 13 publications
(11 citation statements)
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References 30 publications
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“…Subsequently, we predicted and found a targeted binding locus between miR-375 and circ-0072088. MiR-375, an early discovered miR, is lowly expressed in patients with HCC and participates in the growth of HCC by regulating multiple target genes ( Li et al, 2018 ; Liu Z. et al, 2019 ; Wang et al, 2021 ). Our study uncovered the negative association of lowly expressed miR-375 with circ-0072088 in HCC patients and confirmed the regulation of circ-0072088 on miR-375 through RIP and DLR assays.…”
Section: Discussionmentioning
confidence: 99%
“…Subsequently, we predicted and found a targeted binding locus between miR-375 and circ-0072088. MiR-375, an early discovered miR, is lowly expressed in patients with HCC and participates in the growth of HCC by regulating multiple target genes ( Li et al, 2018 ; Liu Z. et al, 2019 ; Wang et al, 2021 ). Our study uncovered the negative association of lowly expressed miR-375 with circ-0072088 in HCC patients and confirmed the regulation of circ-0072088 on miR-375 through RIP and DLR assays.…”
Section: Discussionmentioning
confidence: 99%
“…For example, massive un-physiological overexpression of miR-375 may “always” result in a growth-suppressive phenotype in vitro in prostate cancer cells or for that matter any cancer cell (e.g., oral cancer). To explore this issue in a more unbiased fashion and shed light on the unsatisfactory conclusions about miR-375’s role in cancer, we selected ten of the most recent publications [ 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 ] and ten of the most cited publications [ 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 ] that deal with miR-375 and determined the pro- or anti-growth outcomes of its overexpression or inhibition in these studies. Overexpression using a miR-375 mimic produced growth inhibition and/or induction of apoptosis in 16 of the 17 studies, while miR-375 inhibition had either no effect or mild pro-growth effects in 7 of 10 studies.…”
Section: Mir-375: An Indeterminant Oncogene a Mirage Of A Tumor Smentioning
confidence: 99%
“…The establishment of Wistar rat models were detailed descripted before, and grouping of these rats were according to the Metavir score system (20,21). Here was brief introduction.…”
Section: Animal Experimentsmentioning
confidence: 99%