MiR-410 regulates MET to influence the proliferation and invasion of glioma

Chen, Lingchao; Zhang, Junhe; Yan, Feng; Li, Ruiyan; Sun, Xu; Du, Wei; Piao, Xinyin; Wang, Hanbing; Yang, Dan; Sun, Ying; Li, Xianfeng; Jiang, Tao; Kang, Chunsheng; Li, Yongli; Jiang, Chuanlu

doi:10.1016/j.biocel.2012.06.027

Cited by 89 publications

(72 citation statements)

References 25 publications

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“…There are few reports discussing the cellular functions of miR329 in mammalian cells. However, miR410 has been reported to function as a tumor suppressor in human gliomas (41). Our rescue experiment showed that the reintroduction of Wnt-7b in miR329-or miR410-overexpressing OSCC cells antagonized the effects of miR329 and miR410 on growth inhibition (Fig.…”

Section: Discussionmentioning

confidence: 69%

Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

et al. 2014

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microRNA (miRNA) dysregulation contributes widely to human cancer but has not been fully assessed in oral cancers. In this study, we conducted a global microarray analysis of miRNA expression in 40 pairs of betel quid-associated oral squamous cell carcinoma (OSCC) specimens and their matched nontumorous epithelial counterparts. Eighty-four miRNAs were differentially expressed in the OSCC specimens compared with the matched tissue. Among these downregulated miRNAs, 19 miRNAs were found and mapped to the chromosome 14q32.2 miRNA cluster region, which resides within a parentally imprinted region designated as Dlk-Dio3 and known to be important in development and growth. Bioinformatic analysis predicted two miRNAs from the cluster region, miR329 and miR410, which could potentially target Wnt-7b, an activator of the Wnt-b-catenin pathway, thereby attenuating the Wnt-b-catenin signaling pathway in OSCC. Stable ectopic expression of Wnt-7b in OSCC cells overexpressing miR329 or miR410 restored proliferation and invasion capabilities abolished by these miRNA. Combining a demethylation agent and a histone deacetylase inhibitor was sufficient to reexpress miR329, miR410, and Meg3, consistent with epigenetic regulation of these miRNA in human OSCC. Specifically, arecoline, a major betel nut alkaloid, reduced miR329, miR410, and Meg3 gene expression. Overall, our results provide novel molecular insights into how betel quid contributes to oral carcinogenesis through epigenetic silencing of tumor-suppressor miRNA that targets Wnt-b-catenin signaling. Cancer Res; 74(24); 7560-72. Ó2014 AACR.

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Section: Discussionmentioning

confidence: 69%

Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

et al. 2014

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“…19 We demonstrated that CCNB1 gene, an important cell cycle regulator involved in pituitary tumor behavior, is a target of miRNA-410. Moreover, the restoration of miRNA-410 expression in pituitary adenoma cells resulted in the inhibition of cell proliferation.…”

Section: Introductionmentioning

confidence: 83%

“…24 Moreover, other previous studies have evidenced a tumor suppressor activity for this miRNA. Indeed, miR-410 has been found downregulated gliomas 19 and gastric carcinomas 25 where lower miRNA-410 expression levels significantly correlated with the presence of lymph-node metastasis. Consistently, maintenance of miR-410 expression is associated with a better overall survival in advanced serous ovarian cancer.…”

Section: Discussionmentioning

confidence: 99%

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

et al. 2015

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MicroRNAs (miRNAs) are small noncoding RNAs that act as posttranscriptional regulators of gene expression, and are frequently altered in human neoplasias. Here, we have analyzed the miRNA expression profile of human gonadotroph adenomas versus normal pituitary tissue using a miRNACHIP microarray. We demonstrate that miRNA-410 is downregulated in gonadotroph adenomas when compared with normal pituitary gland. We validate CCNB1 as target of miRNA-410 since its overexpression reduces CCNB1 at protein and mRNA levels, decreasing cell proliferation. In conclusion, our study suggess that the downregulation of miRNA-410 plays a role in the behavior of gonadotroph tumors.

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“…Regarding the individual function of miR-410 and miR-495, a number of reports have linked both of these miRNAs to oncogenic pathways. Some studies have suggested a tumor suppressor role for these miRNAs (43)(44)(45), whereas others have indicated a pro-proliferative effect on tumor growth. Along these lines, miR-410 has been shown to be up-regulated in liver cancer and enhanced tumor cell growth (46).…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2

Clark

Naya

2015

Journal of Biological Chemistry

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Background: MicroRNAs have recently emerged as key regulatory molecules in cardiomyocyte proliferation. Results: miR-410 and miR-495 are regulated by MEF2 in cardiomyocytes, and their overexpression results in increased cardiomyocyte proliferation. Conclusion: miR-410 and miR-495 potently induce cardiomyocyte proliferation by directly inhibiting the coactivator Cited2. Significance: These findings reveal novel microRNAs that can be modulated to stimulate the regeneration of damaged cardiac tissue.

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MiR-410 regulates MET to influence the proliferation and invasion of glioma

Cited by 89 publications

References 25 publications

Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

Downregulated miR329 and miR410 Promote the Proliferation and Invasion of Oral Squamous Cell Carcinoma by Targeting Wnt-7b

Downregulation of miR-410 targeting the cyclin B1 gene plays a role in pituitary gonadotroph tumors

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2

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