miR-429 Modulates the expression of c-myc in human gastric carcinoma cells

Sun, Tiewei; Wang, Chunmei; Xing, Jun; Wu, Danping

doi:10.1016/j.ejca.2011.05.021

Cited by 87 publications

(63 citation statements)

References 47 publications

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“…Dual roles of miR-429 have been suggested in a variety of types of human cancer, including ovarian (12), colorectal (13)(14)(15), esophageal (16) and gastric cancer (17,18), as well as osteosarcoma (19). Yoneyama et al (20) demonstrated that the expression level of miR-429, accompanied with miR-200a/b, was significantly increased in endometrioid endometrial carcinoma (ECC) compared to adjacent normal endometrial tissues.…”

Section: Discussionmentioning

confidence: 99%

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

Xiao

Zhou

2016

Oncology Letters

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Section: Discussionmentioning

confidence: 99%

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

Xiao

Zhou

2016

Oncology Letters

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“…Numerous studies have shown that expression of miRNAs is altered in lung adenocarcinoma (19)(20)(21), indicating that deregulation of miRNAs may play a role in the carcinogenesis of lung adenocarcinoma. Some research has estimated that miRNAs may regulate up to 30% of all human genes and control a variety of cellular processes (27)(28)(29). miRNAs have been shown to be deregulated in various cancers, and their expression levels are related with the diagnosis and prognosis of different types of tumors (29)(30)(31).…”

Section: Discussionmentioning

confidence: 99%

miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9

Zheng

Shi

et al. 2017

Oncology Reports

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Abstract. MicroRNAs (miRNAs) are critical translational regulators that act as oncogenes or tumor-suppressor genes. qRT-PCR assay results showed that the expression levels of miR-125a-5p are lower in lung adenocarcinoma (AD) tissues than expression levels in adjacent non-neoplastic tissues. This relative expression was found to be significantly associated with lymph node metastases. Cell growth, apoptosis, caspase activity and Transwell invasion assay results showed that in two lung adenocarcinoma cell lines transfected with a miR-125a-5p mimic, proliferation and invasion rates were found to be significantly reduced, whereas the apoptosis rate of the miR-125a-5p mimic group was enhanced. Subsequent western blotting and luciferase reporter assays showed that miR-125a-5p is able to bind to putative binding sites within the mRNA 3' untranslated region (UTR) of neural precursor cell expressed, developmentally downregulated 9 (NEDD9). Our findings suggest that miR-125a-5p may serve as a therapeutic agent for lung adenocarcinoma through its major target, NEDD9.

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“…(28,(35)(36)(37)(38)(39)(40) In terms of RCC, there were two reports indicating that let-7a and miR-34a functioned as tumor suppressors through directly binding to c-MYC mRNA. (28,37) We hypothesized that tumorsuppressive miRNAs regulate several oncogenic genes in normal cells, but reduced expression of tumor-suppressive miRNAs causes aberrant expression of oncogenes in cancer cells.…”

Section: Discussionmentioning

confidence: 99%

Tumor‐suppressive microRNA‐135a inhibits cancer cell proliferation by targeting the c‐MYC oncogene in renal cell carcinoma

et al. 2012

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Recently, many studies have suggested that microRNAs (miRNAs) are involved in cancer cell development, invasion, and metastasis of various types of human cancers. In a previous study, miRNA expression signatures from renal cell carcinoma (RCC) revealed that expression of microRNA-135a (miR-135a) was significantly reduced in cancerous tissues. The aim of this study was to investigate the functional significance of miR-135a and to identify miR-135a-mediated molecular pathways in RCC cells. Restoration of mature miR-135a significantly inhibited cancer cell proliferation and induced G 0 ⁄ G 1 arrest in the RCC cell lines caki2 and A498, suggesting that miR-135a functioned as a potential tumor suppressor. We then examined miR-135a-mediated molecular pathways using genome-wide gene expression analysis and in silico analysis. A total of 570 downregulated genes were identified in miR-135a transfected RCC cell lines. To investigate the biological significance of potential miR-135a-mediated pathways, we classified putative miR-135a-regulated genes according to the Kyoto Encyclopedia of Genes and Genomics pathway database. From our in silico analysis, 25 pathways, including the cell cycle, pathways in cancer, DNA replication, and focal adhesion, were significantly regulated by miR-135a in RCC cells. Moreover, based on the results of this analysis, we investigated whether miR-135a targeted the c-MYC gene in RCC. Gain-of-function and luciferase reporter assays showed that c-MYC was directly regulated by miR-135a in RCC cells. Furthermore, c-MYC expression was significantly upregulated in RCC clinical specimens. Our data suggest that elucidation of tumor-suppressive miR-135a-mediated molecular pathways could reveal potential therapeutic targets in RCC. (Cancer Sci 2013; 104: 304-312) R enal cell carcinoma (RCC) is the most common neoplasm of the adult kidney, and approximately 80% of RCC patients are diagnosed with the clear cell RCC (ccRCC) subtype.(1) In the USA, the incidence and mortality rates of RCC have increased in recent years, with approximately 58 000 new cases and 13 000 deaths in 2010.(2) Although surgery is curative for localized disease, a significant percentage of patients developed relapses or metastases with poor prognosis.(3,4) Therefore, researchers have become interested in elucidating the molecular mechanisms of RCC oncogenesis and metastasis, which could lead to development of better prognostic, diagnostic, and therapeutic interventions for the disease.RNA can be divided into two categories, protein-coding RNAs and non-coding RNAs (ncRNAs). It is important to examine the functions of ncRNAs in both normal and diseased tissues and to elucidate their involvement in human diseases, including cancer. MicroRNAs (miRNAs) are endogenous small ncRNA molecules (19-22 bases) that regulate protein-coding gene expression by repressing translation of RNA or cleaving RNA transcripts in a sequence-specific manner.(5) A growing body of evidence suggests that miRNAs are aberrantly expressed in many human cancers and ...

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miR-429 Modulates the expression of c-myc in human gastric carcinoma cells

Cited by 87 publications

References 47 publications

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

miR-429 promotes the proliferation of non-small cell lung cancer cells via targeting DLC-1

miR-125a-5p upregulation suppresses the proliferation and induces the cell apoptosis of lung adenocarcinoma by targeting NEDD9

Tumor‐suppressive microRNA‐135a inhibits cancer cell proliferation by targeting the c‐MYC oncogene in renal cell carcinoma

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