miR-4299 inhibits tumor progression in pancreatic cancer through targeting ADAM17

Liu, Junhong; Ye, Lin; Lin, Kangqiang; Zhong, Tieshan; Luo, Jiguang; Wang, Tao; Suo, Liya; Mo, Qingrong; Li, Shuqun; Chen, Qian; Yu, Yanmin

doi:10.1007/s11010-022-04617-8

Cited by 4 publications

(5 citation statements)

References 49 publications

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“…94 Moreover, miR-4299 enhanced the NKG2D-positive rate and killing ability of NK cells. 94 ADAMs, generically known as sheddases, cleave membrane proteins such as MICA and MICB at the cellular surface and have been implicated in cancer cell immune evasion. 95,96 NK cells can recognize and target cells via the NKG2D receptor.…”

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 98%

“…21 Likewise, it was observed that miR-4299 is lowly expressed in pancreatic cancer tissues and cell lines. 94 In addition, miR-4299 overexpression markedly reduced PDAC cell proliferation in vitro and in vivo by targeting the 3′UTR of ADAM17. 94 Moreover, miR-4299 enhanced the NKG2D-positive rate and killing ability of NK cells.…”

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

“…94 In addition, miR-4299 overexpression markedly reduced PDAC cell proliferation in vitro and in vivo by targeting the 3′UTR of ADAM17. 94 Moreover, miR-4299 enhanced the NKG2D-positive rate and killing ability of NK cells. 94 ADAMs, generically known as sheddases, cleave membrane proteins such as MICA and MICB at the cellular surface and have been implicated in cancer cell immune evasion.…”

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

“…ncRNAs have newly emerged as major regulators of NK cell function in PDAC. 21,94 Herein, Ou et al revealed that in response to hypoxia, PDAC cells upregulate circ_0000977 to sponge miR-153 and attenuate its inhibitory effects on HIF-1α and A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10). 21 They found that miR-153 targets the 3′-UTR of HIF-1α and ADAM10 in PDAC cells and shortens cancer cell viability in hypoxia.…”

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

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Noncoding Ribonucleic Acids (RNAs) May Improve Response to Immunotherapy in Pancreatic Cancer

Ala

2024

ACS Pharmacol. Transl. Sci.

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Pancreatic ductal adenocarcinoma (PDAC) is the seventh most common cause of cancer-related mortality. Despite different methods of treatment, nearly more than 90% of patients with PDAC die shortly after diagnosis. Contrary to promising results in other cancers, immune checkpoint inhibitors (ICIs) showed limited success in PDAC. Recent studies have shown that noncoding RNAs (ncRNAs) are extensively involved in PDAC cell–immune cell interaction and mediate immune evasion in this vicious cancer. PDAC cells recruit numerous ncRNAs to widely affect the phenotype and function of immune cells through various mechanisms. For instance, PDAC cells upregulate miR-301a and downregulate miR-340 to induce M2 polarization of macrophages or overexpress miR-203, miR-146a, and miR-212-3p to downregulate toll-like receptor 4 (TLR4), CD80, CD86, CD1a, major histocompatibility complex (MHC) II, and CD83, thereby evading recognition by dendritic cells. By downregulating miR-4299 and miR-153, PDAC cells can decrease the expression of NK group 2D (NKG2D) and MHC class I chain-related molecules A and B (MICA/B) to blunt the natural killer (NK) cell response. PDAC cells also highly express lncRNA AL137789.1, hsa_circ_0046523, lncRNA LINC00460, and miR-155-5p to upregulate immune checkpoint proteins and escape T cell cytotoxicity. On the other hand, ncRNAs derived from suppressive immune cells promote proliferation, invasion, and drug resistance in PDAC cells. ncRNAs can be applied to overcome resistance to ICIs, monitor the immune microenvironment of PDAC, and predict response to ICIs. This Review article comprehensively discusses recent findings regarding the roles of ncRNAs in the immune evasion of PDAC.

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Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 98%

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

Section: Function In Pdac Ncrnas Modulate Cancer Cell Recognition And...mentioning

confidence: 99%

See 2 more Smart Citations

Noncoding Ribonucleic Acids (RNAs) May Improve Response to Immunotherapy in Pancreatic Cancer

Ala

2024

ACS Pharmacol. Transl. Sci.

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“…Regulates macrophage polarization [50] miR-3907 Promotes cellular differentiation and migration in different types of carcinomas [51] miR-4299 Inhibits tumor progression in pancreatic cancer [52] miR-125a-3p Involved in the pathogenesis of atherosclerosis [53] miR-1246 Contributes to tumor metastasis in lung cancer [54] miR-3614-5p Involved in the pathogenesis of breast cancer, nonsmall cell lung cancer and colorectal cancer Associates to the risk of development of autoimmune disease [55] miR-146a-5p miR-146b-5p…”

Section: Hsa-let7bmentioning

confidence: 99%

MicroRNAs in idiopathic inflammatory myopathies: state-of-the-art and future perspectives

Pettorossi

Gasparotto

Ghirardello

et al. 2023

Current Opinion in Rheumatology

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Purpose of review Idiopathic inflammatory myopathies (IIMs) are a group of rare autoimmune disorders characterized by muscle weakness and inflammation. MicroRNAs (miRNAs) are the main class of small noncoding RNAs regulating a wide range of physiological and pathological processes and play a role in mediating autoimmunity and inflammation. In this review, we summarize the latest knowledge on the role of miRNAs in systemic autoimmune diseases with particular focus on IIMs. Recent findings Study on miRNA expression in IIMs is helping in understanding the pathogenetic basis of the disease at a tissue and systemic level. Several miRNAs, even with a muscle-specific expression (myomiRs), have been shown to be involved in immune and nonimmune mechanisms of myofiber damage. MiRNAs modulate and orchestrate the local inflammatory infiltrate and could be used as potential biomarkers as they correlate with disease activity and response to therapy. Summary IIMs comprise different clinical phenotypes and still little is known about the molecular signature of each subset. Further research about miRNA profiling will provide additional insights in the disease characterization with an expected impact on the therapeutic strategies.

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Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches

Gu,

Liu,

Xin

et al. 2024

Cancer Letters

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miR-4299 inhibits tumor progression in pancreatic cancer through targeting ADAM17

Cited by 4 publications

References 49 publications

Noncoding Ribonucleic Acids (RNAs) May Improve Response to Immunotherapy in Pancreatic Cancer

Noncoding Ribonucleic Acids (RNAs) May Improve Response to Immunotherapy in Pancreatic Cancer

MicroRNAs in idiopathic inflammatory myopathies: state-of-the-art and future perspectives

Fundamental insights and molecular interactions in pancreatic cancer: Pathways to therapeutic approaches

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