miR-448 regulates potassium voltage-gated channel subfamily A member 4 (KCNA4) in ischemia and heart failure

High albumen height by expression of GALNT9 and thin eggshell by decreased Ca2+ transportation caused high hatchability in Huainan partridge chicken

“…Among the DEGs, Potassium Voltage-Gated Channel Subfamily A Member 4 ( KCNA4 , down), Potassium Voltage-Gated Channel Subfamily A Member 5 ( KCNA5 , down), Potassium Voltage-Gated Channel Subfamily E Regulatory Subunit 5 ( KCNE5 , down), KCNN3 (up), Potassium Voltage-Gated Channel Subfamily Q Member 1 ( KCNQ1 , down) belong to Potassium Voltage-Gated Channel Subfamily. Genes KCNA4, KCNA5 , and KCNQ1 encode the K(v)1.4, K(v)1.5 and K(v)7.1 channels ( Nakajo and Kubo, 2015 ; Gyeoung-Jin et al, 2023 ; Hilderink et al, 2020 ). KCNA5 are found plays a regulatory role in proliferation and apoptosis in oligodendrocytes, hippocampus microglia, macrophages, human mammary epithelial cells, ovarian granulosa cell ( Qu et al, 2018 ; Zhou et al, 2021 ).…”

MicroRNAs: Midfielders of Cardiac Health, Disease and Treatment

“…Confirmed to target HCN channels Depresses SAN automaticity Represses calcium channels Elevated in SAN tissue from HF patients Seen to alleviate bradycardia in COVID-19 patients [31][32][33] miR-1 and miR-133 Those with AF show high HCN2/HCN4 and low miR-1/miR-133 compared to older patients with sinus rhythm [34] miR-17-92 and miR-106b-25 Both can be targeted via Pitx2 (which positively regulates them) [35] miR-1976 Seen to be increased in age-related SSS patient plasma [36] miR-423-5p Suggested to be increased in athletes Elevated in bradycardia related endurance training [37] miR-370-3p Decreasing in HF mice restores HCN4 mRNA while partially restoring ventricular function and decreasing mortality [38] miR-448 Decreasing has anti-arrhythmic effects [39] 2. miRNAs in Healthy and Diseased Heart…”

“…Of note, KCNA4 (encoding a K v 1.4 current essential for APD) expression is seen to be diminished in ischaemia and HF human tissue. It is targeted by miR-448, and the inhibition of this miR restores KCNA4 and has antiarrhythmic effects [39]. In this way, restoring enough function to ensure a patient can try to stay fit and healthy is a promising route to explore.…”