miR-455-5p promotes cell growth and invasion by targeting SOCO3 in non-small cell lung cancer

Abstract

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. miR-455-5p has increased expression and the ability to promote tumorigenesis in certain cancers. However, the role of miR-455-5p in NSCLC has not been sufficiently investigated. SOCS3 (suppressor of cytokine signaling 3), an important tumor suppressor, is often aberrantly inactivated in various tumors, but it is currently unclear whether SOCO3 is a target of miR-455-5p. In the present study, we investigated the role of miR-455-5p in NSCLC. We found that the expression of miR-455-5p was up-regulated in NSCLC tumor tissues compared to corresponding noncancerous tissues, and its expression was correlated with metastasis and tumor node metastasis in NSCLC tissue. We then showed that miR-455-5p promoted migration, invasion and proliferation in NSCLC cell lines. Additionally, we also found that SOCS3 was the direct target gene of miR-455-5p. Consistently, the expression of SOCS3 was negatively correlated with the expression of miR-455-5p in NSCLC tissues. We further show that aberrant miR-455-5p expression is partially controlled by activated ERK signaling in NSCLC. Therefore, miR-455-5p could enhance the growth and metastasis of NSCLC by inhibiting SOCS3, thus providing a potential molecular therapeutic target for the treatment of NSCLC patients.

Exploring specific prognostic biomarkers in triple-negative breast cancer

“…To the best of our knowledge, only one study indicated that miR-455-5p was differentially expressed between invasive and non-invasive breast cancer based on the analyses of archived FFPE tissues and laboratory-based barcoded cDNA library 46 . In other cancers, miR-455-5p has been reported as a potential oncogene for non-small cell lung cancer 47 , colon cancer 48 and oral squamous cancer 49 . In our present study, we confirmed these 4 screened DEmiRNAs not only differentially expressed in TNBC cell lines compared to normal breast cell line, but also showed effective regulation on cell proliferation and migration.…”

LncRNA HOXA‐AS3 promotes the malignancy of glioblastoma through regulating miR‐455‐5p/USP3 axis

“…For example, miR-455-5p acts as an oncogene in lung cancer. 25 In contrast, miR-455-5p exerts tumour-suppressive effects in prostate cancer. 26 However, the role of miR-455-5p in GBM has not been revealed.…”

Two prostate cancer‑associated polymorphisms in the 3'UTR of IGF1R influences prostate cancer susceptibility by affecting miRNA binding

“…The expression level and activity of MMP2/9 have been revealed to be regulated by ERK1/2 in 293 and monocytic cells (53). In addition, aberrant miR-455-5p expression is partially regulated by activated ERK signaling in non-small cell lung cancer (54). It is possible that ERK1/2 regulates MMP2 by miR-455 in LNCaP cells.…”