miR-487a promotes progression of gastric cancer by targeting TIA1

Wang, Mingda; Lin, Bohao; Yao, Dongjie; Li, Jin; Xian-chun, Tang; Li, Sanhua; Liu, Yun; Xie, Rui; Yu, Shouyang

doi:10.1016/j.biochi.2018.08.006

Cited by 27 publications

(28 citation statements)

References 35 publications

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“…However, its functions may depend on tumor location. For example, TIA1 inhibits progression of gastric cancer by suppressing tumor cell proliferation and accelerating apoptosis ( 28 ), whereas it serves as an oncogene in esophageal squamous cell carcinoma through promoting cell proliferation ( 29 ).…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Oral Squamous Cell Carcinoma

et al. 2020

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Background Alternative splicing (AS) plays an essential role in tumorigenesis and progression. This study aimed to develop a novel prognostic model based on the AS events to obtain more accurate survival prediction and search for potential therapeutic targets in oral squamous cell carcinoma (OSCC). Methods Seven types of AS events in 326 OSCC patients with RNA-seq were obtained from the TCGA SpliceSeq tool and the TCGA database. Cox analysis, the least absolute shrinkage and selection operator Cox regression and random forest were employed to establish prognostic models. Genomics of Drug Sensitivity in Cancer (GDSC) was adopted to estimate the possible drug sensiticity. Prognostic splicing factor (SF)-AS network was constructed by Cytoscape. Results The final model included 12 AS events, showing satisfactory performance. The area under the curve for 3- and 5-year survival in the training cohort was 0.83 and 0.82, respectively while that in internal validation was 0.83 and 0.82 accordingly. The calibration curve also indicated a satisfactory agreement between the observation and the predictive values. Low-risk patients stratified by the final model presented higher sensitivity to three chemo drugs. Besides, the prognostic SF-AS regulatory network contained five key SFs and 62 AS events. Conclusions We developed a powerful prognostic AS signature for OSCC and deepened the understanding of SF-AS network regulatory mechanisms. Low-risk patients tended to be more sensitive to the three chemo drugs while five key SFs including CELF2, TIA1, HNRNPC, HNRNPK, and SRSF9 were identified as potential prognostic biomarkers, which may offer new prospects for effective therapies of OSCC.

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Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Oral Squamous Cell Carcinoma

et al. 2020

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“…Previous studies reported that the cell inhibition can be induced not only by cell cycle arresting, but also by cell death including cell apoptosis [21,22]. Here, we performed cell apoptosis assay to evaluate the effects of LncRNA HOXB-AS1 on cell apoptosis.…”

Section: Knock-down Of Hoxb-as1 Suppressed Proliferation Of Gbm Cellsmentioning

confidence: 99%

Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis

Chen¹,

Li²,

Qiu³

et al. 2019

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Long non-coding RNAs (lncRNAs) have been proven to play important roles in carcinogenesis and development of numerous cancers, but their biological functions in glioblastoma remain largely unknown. In this study, we found that HOXB-AS1 was highly expressed in human glioblastoma tissues and cell lines, and was associated with survival time of patients. Further analysis showed that knock-down of HOXB-AS1 inhibited cell proliferation via inducing S phase cell cycle arrest and suppressed migration and invasion ability of cells. Mechanism study revealed that HOXB-AS1 is mainly located in cytoplasm and functions as competing endogenous RNA via sponging of miR-885-3p. Moreover, inhibition of miR-885-3p antagonized the effects of HOXB-AS1 knock-down and promoted proliferation, migration and invasion of glioblastoma cells. Finally, we found that sponging of miR-885-3p by HOXB-AS1 could further affect the expression of HOXB2. Taken together, we demonstrate that HOXB-AS1/miR-885-3p/HOXB2 axis regulates proliferation, migration and invasion of glioblastoma cells and can serve as a potential biomarker for the malignancy.

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“…Cells showed an increased proliferation rate and decreased cell apoptosis. Moreover, a GC xenograft mouse model confirmed that overexpression of miR-487a enhances tumor growth in vivo (26).…”

Section: Discussionmentioning

confidence: 63%

Tumor microRNAs Identified by Small RNA Sequencing as Potential Response Predictors in Locally Advanced Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy

Macháčková

Trachtová

Procházka

et al. 2020

Cancer Genomics Proteomics

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Background/Aim: Rectal cancer accounts for approximately one-third of all colorectal cancers. Currently, the standard treatment for locally advanced rectal cancer (LARC) is neoadjuvant chemoradiotherapy (CRT) with capecitabine or 5-fluorouracil followed by curative surgery. Unfortunately, only 20% of patients with LARC present complete pathological response after CRT, whereas in 20-40% cases the response is poor or absent. The aim of our study was to evaluate whether microRNAs (miRNAs) in tumor biopsy specimen have the potential to predict therapeutic response in LARC patients. Patients and Methods: In total 87 LARC patients treated by CRT were enrolled in our prospective study. To identify predictive miRNAs, we used small RNA sequencing in 40 tumor biopsy samples of LARC patients (20 responders, 20 non-responders) and qPCR validation of selected miRNA candidates. Results: In the discovery phase of the study, we identified 69 miRNAs to have significantly different expression between the group of responders (TRG 1,2) and a group of non-responders (TRG 4,5) to neoadjuvant CRT. Among these miRNAs, 48 showed a lower expression and 21 showed higher expression in tumor tissues from poorly responding LARC patients. Five miRNAs were selected for validation, but only miR-487a-3p was confirmed to have a significantly higher expression in the tumor biopsy specimens of non-responders to neoadjuvant CRT (p<0.0006, AUC=0.766). Gene Ontology (GO) clustering and pathway enrichment analysis of the miR-487a-3p mRNA targets, revealed potential mechanisms behind miR-487a-3p roles in chemoradioresistance (e.g. TGF-beta signaling pathway, protein kinase activity, double-stranded DNA binding, or microRNAs in cancer). Conclusion: By combination of miRNA expression profiling and integrative computational biology we identified miR-487a-3p as a potential predictive biomarker of CRT response in LARC patients. Colorectal cancer (CRC) is the third most common cancer worldwide and accounts for approximately 10% of all solid tumors. CRC is the second leading cause of cancer-related deaths, and its incidence is on the rise. Tumors of the rectum 249 This article is freely accessible online.

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miR-487a promotes progression of gastric cancer by targeting TIA1

Cited by 27 publications

References 35 publications

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Oral Squamous Cell Carcinoma

Comprehensive Analysis of Prognostic Alternative Splicing Signatures in Oral Squamous Cell Carcinoma

Long non-coding RNA HOXB-AS1 promotes proliferation, migration and invasion of glioblastoma cells via HOXB-AS1/miR-885-3p/HOXB2 axis

Tumor microRNAs Identified by Small RNA Sequencing as Potential Response Predictors in Locally Advanced Rectal Cancer Patients Treated With Neoadjuvant Chemoradiotherapy

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