miR-544a Stimulates endometrial carcinoma growth via targeted inhibition of reversion-inducing cysteine-rich protein with Kazal motifs

Zheng, Wenjie; Meng, Fan-long; Wang, Lianyun

doi:10.1016/j.mcp.2020.101572

Cited by 8 publications

(6 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, 35 studies investigated the role of miRNAs in the regulation of tumor growth and EC metastasis in vivo in murine models [ 18 , 19 , 24 , 36 , 41 , 42 , 44 , 45 , 49 , 51 , 52 , 53 , 56 , 62 , 69 , 70 , 72 , 73 , 92 , 93 , 101 , 111 , 117 , 119 , 122 , 126 , 128 , 136 , 137 , 144 , 145 , 151 , 157 , 160 , 166 ]. Eight miRNAs were identified as oncomiRNAs in vivo (miR-106a, miR-107-5p, miR-130b, miR-183, miR-222-3p, miR-494-3p, miR-544a, and miR-652) and 27 as tumor suppressor miRNAs (miR-23a, miR-23b, miR-26a, miR-29a-5p, miR-29b, miR-34a, miR-34b, miR-99a, miR-101, miR-129, miR-142, miR-148b, miR-194, miR-199a/b-5p, miR-200c, miR-204, miR-214-3p, miR-302a-5p, miR-326, miR-361, miR-367-3p, miR-372, miR-449a, miR-490-3p, miR-499a, miR-505, and miR-1827).…”

Section: Resultsmentioning

confidence: 99%

“…Further, we collected data from articles investigating the association between the expression of invasion-related miRNAs in tumor tissue and clinical parameters, including OS, DFS, PFS, FIGO stage, histological grade, myometrial invasion, and lymph node metastases. We identified 51 articles that correlated upregulated expression of 25 miRNAs and downregulated expression of 41 miRNAs with at least one clinical parameter ( Table 4 ) [ 18 , 19 , 24 , 25 , 28 , 29 , 32 , 34 , 37 , 38 , 41 , 44 , 49 , 51 , 52 , 56 , 57 , 58 , 60 , 69 , 70 , 71 , 76 , 77 , 78 , 79 , 81 , 84 , 95 , 99 , 100 , 108 , 110 , 111 , 115 , 117 , 120 , 122 , 130 , 131 , 132 , 147 , 154 , 160 , 175 , 176 , 177 , 178 , …”

Section: Resultsmentioning

confidence: 99%

“…)[18,19,24,25,28,29,32,34,37,38,41,44,49,51,52,[56][57][58]60,[69][70][71][76][77][78][79]81,84,95,99,100,108,110,111,115,117,120,122,[130][131][132]147,154,160,[175][176][177][178][179][180][181]. The correlation of miRNA expression and clinical parameters.…”

mentioning

confidence: 99%

See 2 more Smart Citations

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

Klicka

Grzywa

Klinke

et al. 2021

Cancers

View full text Add to dashboard Cite

Endometrial cancer (EC) is the most common genital cancer in women with increasing death rates. MiRNAs are short non-coding RNAs that regulate gene expression on the post-transcriptional levels. Multiple studies demonstrated a fundamental role of miRNAs in the regulation of carcinogenesis. This systematic review is a comprehensive overview of the role of miRNAs in the regulation of cancer cell invasiveness and metastasis in EC. The literature was searched for studies investigating the role of miRNAs in the regulation of invasiveness and metastasis in EC. We explored PubMed, Embase, and Scopus using the following keywords: miRNA, metastasis, invasiveness, endometrial cancer. Data were collected from 163 articles that described the expression and role of 106 miRNAs in the regulation of EC invasiveness and metastasis out of which 63 were tumor suppressor miRNAs, and 38 were oncomiRNAs. Five miRNAs had a discordant role in different studies. Moreover, we identified 66 miRNAs whose expression in tumor tissue or concentration in serum correlated with at least one clinical parameter. These findings suggest a crucial role of miRNAs in the regulation of EC invasiveness and metastasis and present them as potential prognostic factors for patients with EC.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

Klicka

Grzywa

Klinke

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…LEF1-AS1 contributes to proliferation and invasion by regulating the miR-544a/FOXP1 axis in lung cancer [ 29 ]. MiR-544a stimulates endometrial carcinoma growth via targeted inhibition of reversion-inducing cysteine-rich protein with Kazal motifs [ 30 ]. MiRNA-544a regulates the inflammation in spinal cord injury by inhibiting the expression of NEUROD4 [ 31 ] These results provide a good reference for the further study of miR544a in peri-implantitis or periodontitis.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA expression profiles in peri-miniscrew implant crevicular fluid in orthodontics: a pilot study

Yang²,

Cai

et al. 2021

BMC Oral Health

View full text Add to dashboard Cite

Background This study systematically evaluated microRNA (miRNA) expression patterns in peri-miniscrew implant crevicular fluid (PMICF) in orthodontic patients. Methods Next-generation sequencing (NGS) was performed to obtain miRNA profiles in PMICF or gingival crevicular fluid (GCF) collected from 3 healthy volunteers (H), 3 peri-implantitis patients (PMSII) and 5 periodontitis patients (P). MiRNA expression patterns were compared between normal and orthodontic PMICF and GCF. Differentially expressed miRNAs were estimated by quantitative real-time PCR (qRT-PCR). Enrichment analyses of the gene targets controlled by these miRNAs were conducted by Gene Ontology (GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses. Results Compared with healthy donors, in PMSII patients, a total of 206 upregulated miRNAs and 152 downregulated miRNAs were detected in PMICF, while periodontitis patients had 333 upregulated miRNAs and 318 downregulated miRNAs. MiR-544a, miR-1245b-3p, miR-1825, miR-4291, miR-3689e, and miR-4477a were chosen randomly for further examination. qRT-PCR examination confirmed that the expression levels of miR-1245b-3p and miR-4291 were higher in PMSII than in H samples and that the expression levels of miR-1825 were higher in PMSII than in P samples. However, contrary to the NGS results, qRT-PCR analysis showed decreased expression of miR544a in PMSII. MiR3689e and miR4477a expression did not differ significantly among all samples. According to GO and KEGG pathway analyses of miR-1825, miR-4291, and miR-1245b-3p high enrichment of target genes involved in the PI3K-AKT signalling pathway was observed. Conclusions The NGS analysis of normal and orthodontic PMICF/CGF showed different miRNA profiles, which may lay the foundation for future research on the molecular mechanism of PMSII. miR-4291, miR-1245b-3p and miR-1825 may be used as diagnostic markers and potential therapeutic targets for PMSII.

show abstract

“…Although RECK has different signaling pathways of transcriptional regulation [12], accumulating evidence support a role for microRNAs in RECK regulation during the car-cinogenesis processes. It has been reported that RECK is regulated by miR-15a in neuro-blastoma [13], by miR-15b/16, miR-21, miR-372, and miR-373 in colon adenocarcinoma [14], by miR-25 and miR-374b-5p in gastric cancer [15,16], by miR-92a, miR-92b, and miR-96 in lung cancer [17][18][19], by miR-135b and sponging miR-135b in hepatocellular carcinoma [20,21], by miR-182-5p in prostate cancer, in bladder cancer, breast cancer and melanoma [22][23][24][25], by miR-181a-5p, miR-200b, miR-200c and miR-221 in colorectal cancer [26][27][28], by miR-15b-5p in prostate cancer [29], by miR-9 and miR-590-5p in oral squamous cell carcinoma [30,31], by miR-544a in endometrial carcinoma [32], and by miR-30b-3p in glioma [33]. The expression of miR-21 microRNA has been found to be al-tered in almost all types of cancers and it has been classified as an oncogenic microRNA [34].…”

Section: Introductionmentioning

confidence: 99%

Mir-21 Regulates Growth and Migration of Cervical Cancer Cells by RECK Signaling Pathway

Aguilar-Martínez,

Campos-Viguri,

Medina-García

et al. 2024

Preprint

View full text Add to dashboard Cite

Expression of miR-21 has been found to be altered in almost all types of cancers and it has been classified as an oncogenic microRNA. In addition, expression of tumor suppressor gene RECK is associated with miR-21 overexpression in high-grade cervical lesions. In the present study we analyze the role of miR-21 in RECK gene regulation in cervical cancer cells. To identify the downstream cellular target genes of upstream miR-21, we silenced endogenous miR-21 expression using siRNAs. We analyzed the expression of miR-21 and RECK, as well as functional effects on cell proliferation and migration. We found that in cervical cancer cells there was an inverse correlation between miR-21 expression and RECK mRNA and protein expression. SiRNAs to miR-21 increased luciferase reporter activity in construct plasmids containing the RECK-3′-UTR microRNA response elements MRE21-1, MRE21-2, and MRE21-3. The role of miR-21 in cell proliferation was also analyzed and cancer cells transfected with siRNAs exhibited a markedly reduced cell proliferation and migration. Our findings indicate that miR-21 post-transcriptionally down-regulates the expression of RECK to promote cell proliferation and cell migration inhibition in cervical cancer cell survival. Therefore, miR-21 and RECK may be potential therapeutic targets in gene therapy for cervical cancer.

show abstract

miR-544a Stimulates endometrial carcinoma growth via targeted inhibition of reversion-inducing cysteine-rich protein with Kazal motifs

Cited by 8 publications

References 29 publications

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

The Role of miRNAs in the Regulation of Endometrial Cancer Invasiveness and Metastasis—A Systematic Review

MicroRNA expression profiles in peri-miniscrew implant crevicular fluid in orthodontics: a pilot study

Mir-21 Regulates Growth and Migration of Cervical Cancer Cells by RECK Signaling Pathway

Contact Info

Product

Resources

About