MiR-550a-3p restores damaged vascular smooth muscle cells by inhibiting thrombomodulin in an &lt;em&gt;in vitro&lt;/em&gt; atherosclerosis model

Chen, Shiyuan; Zhang, Longfei; Feng, Benchi; Wang, Wei; Liu, Delang; Zhao, Xinyu; Yu, C. X.; Wang, Xiaogao; Gao, Yong

doi:10.4081/ejh.2022.3429

Cited by 2 publications

(1 citation statement)

References 45 publications

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“…Other miRNAs were differentially expressed in AHI versus CHI. The first was hsa-miR-550a-3p, which inhibits the growth of vascular smooth muscle cells [ 32 ], and the second was hsa-miR-296-5p, known to be a tumor suppressor and involved in cell growth, neuronal differentiation, and survival [ 33 ]. This latter miRNA was downregulated in HIV patients [ 34 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

Human and Viral microRNA Expression in Acute and Chronic HIV Infections

Lazzari,

Rozera,

Gagliardini

et al. 2024

Viruses

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Human and viral microRNAs (miRNAs) are involved in the regulation of gene transcription, and the establishment of their profiles in acute (AHI) and chronic (CHI) HIV infections may shed light on the pathogenetic events related to different phases of HIV disease. Next-generation sequencing (NGS) of miRNA libraries was performed, and the reads were used to analyze miRNA differential expression in the plasma with AHI and CHI. Functional analysis was then undertaken to investigate the biological processes characterizing the two phases of HIV infection. Except for hsa-miR-122-5p, which was found in 3.39% AHI vs. 0.18% CHI, the most represented human miRNAs were similarly represented in AHI and CHI. However, when considering the overall detected miRNAs in AHI and CHI, 15 displayed differential expression (FDR p < 0.05). Functional analysis identified 163 target mRNAs involved in promoting angiogenesis activation in AHI versus CHI through the action of hsa-miR10b-5p, hsa-miR1290, hsa-miR1-3p, and hsa-miR296-5p. The viral miRNAs detected, all belonging to herpesviruses, accounted for only 0.014% of total reads. The present data suggest that AHI patients exhibit strong innate immune activation through the upregulation of hsa-miR-122-5p and early activation of angiogenesis. More specific investigations are needed to study the role of viral miRNAs in HIV pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Human and Viral microRNA Expression in Acute and Chronic HIV Infections

Lazzari,

Rozera,

Gagliardini

et al. 2024

Viruses

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Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls

et al. 2023

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Polyneuropathies (PNP) are the most common type of disorder of the peripheral nervous system in adults. However, information on microRNA expression in PNP is lacking. Following microRNA sequencing, we compared the expression of microRNAs in the serum of patients experiencing chronic painful PNP with healthy age-matched controls. We have been able to identify four microRNAs (hsa-miR-3135b, hsa-miR-584-5p, hsa-miR-12136, and hsa-miR-550a-3p) that provide possible molecular links between degenerative processes, blood flow regulation, and signal transduction, that eventually lead to PNP. In addition, these microRNAs are discussed regarding the targeting of proteins that are involved in high blood flow/pressure and neural activity dysregulations/disbalances, presumably resulting in PNP-typical symptoms such as chronical numbness/pain. Within our study, we have identified four microRNAs that may serve as potential novel biomarkers of chronic painful PNP, and that may potentially bear therapeutic implications.

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MiR-550a-3p restores damaged vascular smooth muscle cells by inhibiting thrombomodulin in an <em>in vitro</em> atherosclerosis model

Cited by 2 publications

References 45 publications

Human and Viral microRNA Expression in Acute and Chronic HIV Infections

Human and Viral microRNA Expression in Acute and Chronic HIV Infections

Differential Expression of microRNAs in Serum of Patients with Chronic Painful Polyneuropathy and Healthy Age-Matched Controls

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