2021
DOI: 10.1016/j.biomaterials.2021.121242
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MiR-6924-5p-rich exosomes derived from genetically modified Scleraxis-overexpressing PDGFRα(+) BMMSCs as novel nanotherapeutics for treating osteolysis during tendon-bone healing and improving healing strength

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Cited by 43 publications
(72 citation statements)
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“…Among them, exosome‐derived miRNAs are recognized as important mediators of intercellular communication and potential candidates for disease therapy 40 . Additionally, studies have shown that gene manipulation of MSCs plays a stronger therapeutic role by changing the expression of their exosomes derived miRNA 41,42 . Therefore, whether some miRNAs specifically expressed in IL‐35‐ASCexos play a role in this process needs to be further explored, which will be the focus of our follow‐up research.…”
Section: Discussionmentioning
confidence: 99%
“…Among them, exosome‐derived miRNAs are recognized as important mediators of intercellular communication and potential candidates for disease therapy 40 . Additionally, studies have shown that gene manipulation of MSCs plays a stronger therapeutic role by changing the expression of their exosomes derived miRNA 41,42 . Therefore, whether some miRNAs specifically expressed in IL‐35‐ASCexos play a role in this process needs to be further explored, which will be the focus of our follow‐up research.…”
Section: Discussionmentioning
confidence: 99%
“…miRNAs have been reported to regulate multiple processes in bone, such as osteoblast and osteoclast proliferation and differentiation [ 67 ]. Recent studies have shown that exosomal miRNAs can regulate bone development [ 10 ], inhibit osteoclast activity [ 68 ] and improve fracture repair [ 26 ] by competitively inhibiting post-transcriptional gene expression. However, exosomes alone showed poor bone regeneration effects due to their limited osteogenic inductive ability [ 69 , 70 , 71 ].…”
Section: Mirnas Mediating the Regulation Of Bmsc-evs On Bone Metabolismmentioning
confidence: 99%
“…Recent studies have emphasized that, in addition to ncRNAs, a large number of mRNAs and functional structural proteins are enriched in exosomes [ 150 , 151 ], which suggests that BMSC-Exos may also participate in the regulation of bone metabolism through their encapsulated mRNA and protein components [ 68 ]. Scleraxis (Scx) is a helix-loop-helix transcription factor, and the overexpression of Scx promotes bone formation [ 152 , 153 ].…”
Section: Protein-modified Bmsc-evs Regulating Bone Metabolismmentioning
confidence: 99%
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