MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma

Feng, Xinrong; Xue, Huani; Guo, Shuiling; Chen, Yan; Zhang, Xingfeng; Tang, Xiangqin

doi:10.23736/s0031-0808.19.03682-6

Cited by 10 publications

(8 citation statements)

References 5 publications

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“…The regulation of miRNAs on tumorigenesis and tumor progression has been demonstrated in various cancers, such as pancreatic cancer (Wu et al, 2018), colorectal cancer (Li et al, 2018), and OSCC (Kang, Zhang, Sun, Wen, & Sun, 2018). MiR-4282 is newly discovered to be a tumor suppressor in colorectal carcinoma, inhibiting proliferation and mobility by targeting semaphoring 3E (Kang, Wang, Wang, Shen, & Guan, 2016), and it also exerted antitumor function in breast cancer by targeting Myc (Zhao & Jiang, 2018), but there remains no report about its role in OSCC.…”

mentioning

confidence: 99%

MiR‐4282 inhibits tumor progression through down‐regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma

Zhang

Huang

et al. 2020

Journal Cellular Physiology

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Oral squamous cell carcinoma (OSCC) is the most aggressive type of head and neck cancer with an unsatisfactory 5‐year survival rate. MicroRNAs are a group of small noncoding RNAs reported to serve important roles in carcinogenesis, inhibiting certain gene expression via targeting the 3′‐untranslated region of messenger RNAs (mRNAs). MiR‐4282 has been newly discovered to be a tumor suppressor in colorectal cancer, but it has never been studied in OSCC. The present study aimed to uncover the role of miR‐4282 in OSCC. We first confirmed that miR‐4282 was downregulated in OSCC and validated its prognostic significance. Through gain‐of‐function assays, miR‐4282 was discovered to inhibit proliferation, migration, and epithelial‐to‐mesenchymal transition, and induce apoptosis. By mechanistic research, we predicted via bioinformatics tools and confirmed by luciferase reporter and pulldown assays that miR‐4282 targeted LIN28B, an RNA‐binding protein, which has been reported to regulate RNA stability in cancers. Furthermore, we confirmed the interaction between LIN28B and zinc finger and BTB domain containing 2 (ZBTB2), and validated that miR‐4282 regulated mRNA stability of ZBTB2 by inhibiting LIN28B. Rescue assays proved that miR‐4282 inhibited tumor progression through LIN28B/ZBTB2 axis. In vivo assays proved that miR‐4282 inhibited tumor growth in OSCC. In conclusion, the present study revealed that miR‐4282 inhibited tumor progression through downregulation of ZBTB2 by targeting LIN28B in OSCC cells, indicating miR‐4282 as a novel biomarker for OSC.

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mentioning

confidence: 99%

MiR‐4282 inhibits tumor progression through down‐regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma

Zhang

Huang

et al. 2020

Journal Cellular Physiology

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“…VDAC1 is a miR-874-3p target gene, and miR-874-3p inhibits its expression in breast cancer cells. miR-874-3p has been shown to affect the expression of a variety of target genes, including GDPD5, FOXM1, FAM84A, and ADAM19 [ 22 , 24 , 39 , 40 ]. However, no articles have reported the targeting link between miR-874-3p and VDAC1 and the role of miR-874-3p in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…It has been reported that miR-100, miR-122, miR-145, and miR-205 are down-regulated in breast cancer [14][15][16][17], while miR-1228, miR-150, miR-155, and miR-330-3p are up-regulated in breast cancer [18][19][20][21]. Recent study has shown that miR-874-3p expression is aberrant in liver cancer, osteosarcoma, colon cancer, and ovarian cancer [22][23][24][25], but our data shows that the expression of miR-874-3p is lowered in breast cancer.…”

Section: Introductionmentioning

confidence: 99%

miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

Yang

Wang²,

et al. 2023

Aging

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Breast cancer is an important cause of crisis for women's life and health. Voltage-dependent anion channel 1 (VDAC1) is mainly localized in the outer mitochondrial membrane of all eukaryotes, and it plays a crucial role in the cell as the main interface between mitochondria and cellular metabolism. Through bioinformatics, we found that VDAC1 is abnormally highly expressed in breast cancer, and the prognosis of breast cancer patients with high VDAC1 expression is poor. Through in vivo and in vitro experiments, we found that VDAC1 can promote the proliferation, migration and invasion of breast cancer cells. Further research we found that VDAC1 can activate the wnt signaling pathway. Through analysis, we found that miR-874-3p can regulate the expression of VDAC1, and the expression of miR-874-3p is decreased in breast cancer, resulting in the increase of VDAC1 expression. Our findings will provide new targets and ideas for the prevention and treatment of breast cancer.

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“…Similar to miR-296, miR-874 also has two subtypes, miR-874-3p and miR-874-5p (105). Recent studies have confirmed the antitumor effects of miR-874 in gastric cancer (106), osteosarcoma (107,108), glioma (109), epithelial ovarian cancer (110), and nasopharyngeal carcinoma (111). In gastric cancer, miR-874 was demonstrated to target aquaporin-3, and downregulate the levels of MMP2, MMP9, MT1-MMP, and Bcl-2, thus inducing cell apoptosis and inhibiting cell invasion (112).…”

Section: Regulation Of Stat3 In Ecmentioning

confidence: 96%

Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review)

et al. 2022

Int J Oncol

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MiR-874-3p suppresses cell proliferation and invasion by targeting ADAM19 in nasopharyngeal carcinoma

Cited by 10 publications

References 5 publications

MiR‐4282 inhibits tumor progression through down‐regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma

MiR‐4282 inhibits tumor progression through down‐regulation of ZBTB2 by targeting LIN28B in oral squamous cell carcinoma

miRNA-874-3p inhibits the migration, invasion and proliferation of breast cancer cells by targeting VDAC1

Molecular mechanism, regulation, and therapeutic targeting of the STAT3 signaling pathway in esophageal cancer (Review)

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