miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A)

Maruyama, Nobuyuki; Umikawa, Masato; Matsumoto, Hirofumi; Maruyama, Tessho; Nishihara, Kazuhide; Nakasone, Toshiyuki; Matayoshi, Akira; Goto, Takahiro; Hirano, Fusahiro; Arasaki, Akira; Nakamura, Hiroyuki; Matsuzaki, Goro; Takaesu, Giichi

doi:10.21873/anticanres.14631

Cited by 6 publications

(6 citation statements)

References 78 publications

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“…44 In contrast with our findings, overexpression of hsa-miR-935 was recently reported to inhibit oral cancer cell lines by inducing inositol polyphosphate-4-phosphatase type I A. 45 On the other hand, contradictory roles of hsa-miR-935 as a tumor-promoting and suppressing miRNA have both been reported in non-small cell lung cancer, and the same may be true in HNSCC. 46,47 There were a large number of shallow deletions and gains on multiple chromosome arms occurring at higher frequencies in tumors of Black patients compared to White patients.…”

Section: Discussioncontrasting

confidence: 99%

“…In breast cancer, PRG4 has been shown suppress cancer cell invasion by preventing cell adhesion and inducing tumor‐suppressive transforming growth factor beta 44 . In contrast with our findings, overexpression of hsa‐miR‐935 was recently reported to inhibit oral cancer cell lines by inducing inositol polyphosphate‐4‐phosphatase type I A 45 . On the other hand, contradictory roles of hsa‐miR‐935 as a tumor‐promoting and suppressing miRNA have both been reported in non‐small cell lung cancer, and the same may be true in HNSCC 46,47 …”

Section: Discussioncontrasting

confidence: 87%

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Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer

et al. 2022

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Background Numerous studies of head and neck squamous cell carcinoma (HNSCC) have demonstrated disparate outcomes by race and ethnicity. Beyond known associations with socioeconomic variables, whether these are also associated with differences in tumor molecular composition has thus far been poorly explored. Methods We downloaded clinical and multiplatform molecular data from The Cancer Genome Atlas and other published studies. These were compared between non‐Hispanic Black (n = 43) and White (n = 354) patients with non‐HPV‐related tumors, using multivariable models. Publicly available validation cohorts were used. Results Black patients had poorer progression‐free survival than White patients. Tumors of Black patients had greater copy number aberrations, and increased SFRP1 methylation and miRNA‐mediated PRG4 silencing associated with poor survival. PI3K/AkT/mTOR pathway proteins were differentially expressed. Conclusions There are molecular differences between tumors of Black and White patients that may partially account for differences in survival. These may inform targeted treatment decisions to achieve equitable outcomes.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussioncontrasting

confidence: 87%

Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer

et al. 2022

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“…It has been reported that non-coding RNAs like microRNA (miRNA) and lncRNA regulate gene expression in cancer cells (14,(50)(51)(52). Recent report showed that the expression of some miRNAs are differentially expressed in HSC-3 and HSC-3-M3 cells (53). Thus, it would be of interest for future studies to assess the entire transcriptome including noncoding RNAs in these cell lines.…”

Section: Discussionmentioning

confidence: 99%

Transcriptomic Profiling Predicts Multiple Pathways and Molecules Associated With the Metastatic Phenotype of Oral Cancer Cells

Ideta

Tagawa

Hayashi

et al. 2021

Cancer Genomics Proteomics

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Background/Aim: Metastasis to cervical lymph nodes of oral squamous cell carcinoma (OSCC) leads to a poor prognosis. The present study aimed at investigating the pathways and molecules associated with OSCC metastasis. Materials and Methods: The transcriptome between HSC-3 cells and their highly metastatic subline, HSC-3-M3 cells, was examined using gene expression microarray. Gene enrichment analyses and Ingenuity Pathway Analysis were performed. Kaplan-Meier plot analysis using a publicly available dataset was conducted to assess whether candidate molecules are prognosticators. Results: A total of 1,018 genes were differentially expressed, and the inflammatory pathway and NF-ĸB were predicted to be activated in HSC-3-M3 cells. CSF2 was suggested to be an indicator of poor prognosis in head and neck cancers. Conclusion: Inflammation and NF-ĸB may be involved in the metastasis of OSCC, and CSF2 is a promising diagnostic and therapeutic molecule. Moreover, HSC-3-M3 cells are a useful cell line model for studying OSCC progression.

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“…In addition, miR-31 regulated OSCC cell metastasis [ 10 ]. Moreover, miR-935 hindered OSCC progression [ 15 ]. Besides, miR-153-3p was found to regulate epithelial-mesenchymal transition (EMT) in OSCC cells [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis

Long

Zhu

2022

Bioengineered

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Oral squamous cell carcinoma (OSCC) is a common cancer with high recurrence, metastasis rates and poor prognosis. Circular RNAs (circRNAs) take part in regulating OSCC. Herein, we examined the role of circ_0008068 in OSCC. The circ_0008068, Katanin p60 ATPase-containing subunit A-like 1 (KATNAL1) mRNA, microRNA-153-3p (miR-153-3p) and acylgycerol kinase (AGK) contents were indicated by quantitative real-time polymerase chain reaction (qRT-PCR) and western blot. Moreover, in vitro and in vivo assays were conducted to scrutinize the effects of circ_0008068 on OSCC. Additionally, the contact between miR-153-3p and circ_0008068 or AGK was assessed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. Thereafter, we found that the appearance of circ_0008068 and AGK was increased, and miR-153-3p content was diminished in OSCC. Circ_0008068 lack subdued cell proliferation, migration, invasion, tube formation and glycolysis metabolism, but stimulated cell apoptosis in OSCC. In addition, circ_0008068 bound to miR-153-3p to modulate the expression of its target AGK. Besides, miR-153-3p was validated to act as a tumor suppressor in OSCC tumorigenesis by suppressing AGK. Additionally, circ_0008068 knockdown also attenuated tumor growth in nude mice. In all, circ_0008068 expedited the growth of OSCC by miR-153-3p/AGK axis. Abbreviations: OSCC: Oral squamous cell carcinoma; AGK: Acylgycerol kinase; CircRNA: Circular RNA; KATNAL1: Katanin p60 ATPase-containing subunit A-like 1; qRT-PCR: Quantitative real-time polymerase chain reaction; miRNAs/miRs: MicroRNAs; RIP: RNA immunoprecipitation; 3′UTR3’: -untranslated region; HK2: Hexokinase 2; LDHA Lactate dehydrogenase A; IHC: Immunohistochemistry; CCK8: Cell counting kit-8; GAPDH: Glyceraldehyde-3-phosphate dehydrogenase

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miR-935 Inhibits Oral Squamous Cell Carcinoma and Targets Inositol Polyphosphate-4-phosphatase Type IA (INPP4A)

Cited by 6 publications

References 78 publications

Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer

Tumor molecular differences associated with outcome disparities of Black patients with head and neck cancer

Transcriptomic Profiling Predicts Multiple Pathways and Molecules Associated With the Metastatic Phenotype of Oral Cancer Cells

Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis

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