miR‐942‐5p prevents sepsis‐induced acute lung injury via targeting TRIM37

Lü, Qiang; Zhang, Dinggao; Liu, Hui; Xu, Hao

doi:10.1111/iep.12413

Cited by 12 publications

(9 citation statements)

References 42 publications

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“…The same results were obtained by Lu, who evaluated the role of miR-942-5p, but through in vitro experiments, thus demonstrating the effects of reduction in inflammation and apoptosis only. Thanks to their experiments, they demonstrated that miR-942-5p exerts its effect by targeting and inhibiting TRIM37 [ 219 ].…”

Section: Resultsmentioning

confidence: 99%

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Maiese

Scatena

Costantino

et al. 2022

IJMS

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Sepsis is a critical condition characterized by increased levels of pro-inflammatory cytokines and proliferating cells such as neutrophils and macrophages in response to microbial pathogens. Such processes lead to an abnormal inflammatory response and multi-organ failure. MicroRNAs (miRNA) are single-stranded non-coding RNAs with the function of gene regulation. This means that miRNAs are involved in multiple intracellular pathways and thus contribute to or inhibit inflammation. As a result, their variable expression in different tissues and organs may play a key role in regulating the pathophysiological events of sepsis. Thanks to this property, miRNAs may serve as potential diagnostic and prognostic biomarkers in such life-threatening events. In this narrative review, we collect the results of recent studies on the expression of miRNAs in heart, blood, lung, liver, brain, and kidney during sepsis and the molecular processes in which they are involved. In reviewing the literature, we find at least 122 miRNAs and signaling pathways involved in sepsis-related organ dysfunction. This may help clinicians to detect, prevent, and treat sepsis-related organ failures early, although further studies are needed to deepen the knowledge of their potential contribution.

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Section: Resultsmentioning

confidence: 99%

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Maiese

Scatena

Costantino

et al. 2022

IJMS

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“…However, most studies have focused on inflammation- and apoptosis-related pathways. Lu et al (12) suggested that miR-942-5p protects against LPS-induced ALI by inhibiting apoptosis and inflammation in A549 cells through negative TRIM37 regulation. Similarly, Jiang and Zhang (13) illustrated that the overexpression of lnc ZFAS1 can inhibit apoptosis and ameliorate the inflammatory responses of ALI in sepsis, possibly by targeting the expression of miR-193a-3p.…”

Section: Discussionmentioning

confidence: 99%

Regulatory role of noncoding RNA in sepsis and sepsis-associated organ dysfunction: an updated systematic review

Zhang

Yang

Liu

et al. 2022

Shock

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Background: The exact molecular mechanisms underlying sepsis remain unclear. Accumulating evidence has shown that noncoding RNAs (ncRNAs) are involved in sepsis and sepsis-associated organ dysfunction (SAOD). Methods: We performed this updated systematic review focusing mainly on research conducted in the last 5 years regarding ncRNAs associated with sepsis and SAOD. The following medical subject headings were used in the PubMed database from October 1, 2016, to March 31, 2022: "microRNA," "long noncoding RNA," "circular RNA," "sepsis," and/or "septic shock." Studies investigating the role of ncRNAs in the pathogenesis of sepsis and as biomarkers or therapeutic targets in the disease were included. Data were extracted in terms of the role of ncRNAs in the pathogenesis of sepsis and their applicability for use as biomarkers or therapeutic targets in sepsis. The quality of the studies was assessed using a modified guideline from the Systematic Review Center for Laboratory Animal Experimentation. Results: A total of 537 original studies investigated the potential roles of ncRNAs in sepsis and SAOD. Experimental studies in the last 5 years confirmed that long ncRNAs have important regulatory roles in sepsis and SAOD. However, studies on circular RNAs and sepsis remain limited, and more studies should be conducted to elucidate this relationship. Among the included studies, the Systematic Review Center for Laboratory Animal Experimentation scores ranged from 3 to 7 (an average score of 3.78). Notably, 94 ncRNAs were evaluated as potential biomarkers for sepsis, and selective reporting of the sensitivity, specificity, and receiver operating characteristic curve was common. A total of 117 studies demonstrated the use of ncRNAs as potential therapeutic targets in sepsis and SAOD. At a molecular level, inflammation-related pathways, mitochondrial dysfunction, cell apoptosis, and/or oxidative stress were the most extensively studied. Conclusion: This review suggests that ncRNAs could be good biomarkers and therapeutic candidates for sepsis and SAOD. Prospective, large-scale, and multicenter cohort studies should be performed to evaluate specific ncRNAs as biomarkers and test the organ-specific delivery of these regulatory molecules when used as therapeutic targets.

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“…miRNAs are non‐coding endogenous RNAs that are implicated in the diagnosis of sepsis via the control of various genes at the post‐transcriptional level through translational repression or mRNA degradation 7 . Some articles have mentioned that miRNAs could be considered to be a novel biomarker in sepsis 8,9 . Moreover, there are also studies highlighting that miRNAs could induce or suppress ALI during sepsis 10,11 .…”

Section: Introductionmentioning

confidence: 99%

miR‐126‐5p expression in the plasma of patients with sepsis‐induced acute lung injury and its correlation with inflammation and immune function

Mao

Wu²,

Xu³

2023

Clinical Respiratory J

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Objective: This work was implemented to elucidate the miR-126-5p expression in the plasma of patients with sepsis-induced acute lung injury (ALI) and its correlation with inflammation and immune function. Methods:The peripheral blood of patients with sepsis-induced ALI was obtained, and the levels of inflammatory factors (interleukin-6 [IL-6],C-reactive protein [CRP], and procalcitonin [PCT]) were determined. Meanwhile, T lymphocyte subsets (CD3+, CD4+, and CD8+), and immunoglobulins (IgA, IgM, and IgG) were tested. miR-126-5p and TRAF6 mRNA expression in plasma was assessed. Receiver operating characteristic (ROC) curve was performed to assess the diagnostic accuracy of miR-126-5p in sepsis without ALI and sepsis with ALI. Correlation between miR-126-5p expression and clinical indicators was analyzed. The targets of miR-126-5p were predicted using the bioinformatics method, and the direct targets were verified through investigations.Results: miR-126-5p expression in plasma of patients with sepsis-induced ALI was reduced than that of patients with sepsis without ALI. miR-126-5p expression was negatively correlated with IL-6, CRP, and PCT but positively correlated with IgA, IgM, and IgG as well as CD3+, CD4+, and CD8+ in patients with sepsis-induced ALI. ROC curve suggested that miR-126-5p (AUC: 0.777; 95%CI: 0.689-0.866) could distinguish patients with sepsis with ALI from patients with sepsis without ALI. TRAF6 expression in patients with sepsis-induced ALI was higher than that in patients with sepsis without ALI.TRAF6 was a target gene of miR-126-5p, Conclusion: This research highlights that miR-126-5p is reduced in the plasma of patients with sepsis-induced ALI, and miR-126-5p relates to systemic inflammation and immune function indicators.

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miR‐942‐5p prevents sepsis‐induced acute lung injury via targeting TRIM37

Cited by 12 publications

References 42 publications

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Expression of MicroRNAs in Sepsis-Related Organ Dysfunction: A Systematic Review

Regulatory role of noncoding RNA in sepsis and sepsis-associated organ dysfunction: an updated systematic review

miR‐126‐5p expression in the plasma of patients with sepsis‐induced acute lung injury and its correlation with inflammation and immune function

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