MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking

Peng, Hsuan Yu; Hsiao, Jenn Ren; Chou, Sung Tau; Hsu, Yuan Ming; Wu, Guan Hsun; Shieh, Yi‐Shing; Shiah, Shine-Gwo

doi:10.1016/j.neo.2020.08.005

Cited by 34 publications

(38 citation statements)

References 75 publications

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“…1 d) and more details have been presented as Supplementary Data 1 . Further, we have also compared this data with another dataset (GSE37991) 37 – 41 in Supplementary Data 2 . Here, we also observe that both the datasets share a large number of vital DEGs and the pathways.…”

Section: Resultsmentioning

confidence: 99%

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Bajrai

Sohrab

Mobashir

et al. 2021

Sci Rep

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There are a few biological functions or phenomenon which are universally associated with majority of the cancers and hypoxia and immune systems are among them. Hypoxia often occurs in most of the cancers which helps the cells in adapting different responses with respect to the normal cells which may be the activation of signaling pathways which regulate proliferation, angiogenesis, and cell death. Similar to it, immune signaling pathways are known to play critical roles in cancers. Moreover, there are a number of genes which are known to be associated with these hypoxia and immune system and appear to direct affect the tumor growth and propagations. Cancer is among the leading cause of death and oral cancer is the tenth-leading cause due to cancer death. In this study, we were mainly interested to understand the impact of alteration in the expression of hypoxia and immune system-related genes and their contribution to head and neck squamous cell carcinoma. Moreover, we have collected the genes associated with hypoxia and immune system from the literatures. In this work, we have performed meta-analysis of the gene and microRNA expression and mutational datasets obtained from public database for different grades of tumor in case of oral cancer. Based on our results, we conclude that the critical pathways which dominantly enriched are associated with metabolism, cell cycle, immune system and based on the survival analysis of the hypoxic genes, we observe that the potential genes associated with head and neck squamous cell carcinoma and its progression are STC2, PGK1, P4HA1, HK1, SPIB, ANXA5, SERPINE1, HGF, PFKM, TGFB1, L1CAM, ELK4, EHF, and CDK2.

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Section: Resultsmentioning

confidence: 99%

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Bajrai

Sohrab

Mobashir

et al. 2021

Sci Rep

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“…Thus, miRNAs appear to play an important role in the development of smoking-related cancer. For example, cigarette smoking can induce miR-994 expression in oral cancer [ 28 ]. The expression of miR-21 was increased by cigarette smoke extract exposure in colorectal cancer [ 29 ], and the expression of this miRNA was elevated in esophageal cancers patients with consistent cigarette smoking [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Tumor Suppressor miR-584-5p Inhibits Migration and Invasion in Smoking Related Non-Small Cell Lung Cancer Cells by Targeting YKT6

Lee

Park

Sung

et al. 2021

Cancers

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Cigarette smoke (CS) affects the expression of microRNAs (miRNAs), which are important regulators of gene expression by inducing DNA methylation. However, the effects of smoking on miRNA expression have not been fully elucidated in smoking-related lung carcinogenesis. Therefore, in this study, to investigate the change of miRNA expression pattern and to identify tumor suppressor miRNAs by smoking in lung carcinogenesis, we used lung carcinogenesis model cell lines that, derived from a murine xenograft model with human bronchial epithelial cells (BEAS-2B), exposed CS or not. The microarray analysis revealed that miR-584-5p expression was downregulated with cancer progression in lung carcinogenesis model cell lines. We confirmed by pyrosequencing that the methylation level of the miR-584-5p promoter increased with cancer progression. In vitro and in vivo experiments showed that miR-584-5p suppressed migration and invasion in non-small cell lung cancer (NSCLC) cells by targeting YKT6. Furthermore, we showed that high level of YKT6 was associated with a poor survival rate in NSCLC patients with a history of smoking. These results suggest that miR-584-5p acts as a tumor suppressor and is a potential molecular biomarker for smoking-related NSCLC.

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“…Peng et al. [ 27 ] found that NNK upregulated the expression level of miR‐944 in OSCC cells. Furthermore, miR‐944 elicited pro‐inflammation cytokines secretion, migration, and invasion, ultimately promoting the OSCC process.…”

Section: Overview On Oscc and Chemoresistancementioning

confidence: 99%

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

Meng¹,

Lou

Yang³

et al. 2021

Cancer Communications

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Oral squamous cell carcinoma (OSCC), the eighth most prevalent cancer in the world, arises from the interaction of multiple factors including tobacco, alcohol consumption, and betel quid. Chemotherapeutic agents such as cisplatin, 5‐fluorouracil, and paclitaxel have now become the first‐line options for OSCC patients. Nevertheless, most OSCC patients eventually acquire drug resistance, leading to poor prognosis. With the discovery and identification of non‐coding RNAs (ncRNAs), the functions of dysregulated ncRNAs in OSCC development and drug resistance are gradually being widely recognized. The mechanisms of drug resistance of OSCC are intricate and involve drug efflux, epithelial‐mesenchymal transition, DNA damage repair, and autophagy. At present, strategies to explore the reversal of drug resistance of OSCC need to be urgently developed. Nano‐delivery and self‐cellular drug delivery platforms are considered as effective strategies to overcome drug resistance due to their tumor targeting, controlled release, and consistent pharmacokinetic profiles. In particular, the combined application of new technologies (including CRISPR systems) opened up new horizons for the treatment of drug resistance of OSCC. Hence, this review explored emerging regulatory functions of ncRNAs in drug resistance of OSCC, elucidated multiple ncRNA‐meditated mechanisms of drug resistance of OSCC, and discussed the potential value of drug delivery platforms using nanoparticles and self‐cells as carriers in drug resistance of OSCC.

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MiR-944/CISH mediated inflammation via STAT3 is involved in oral cancer malignance by cigarette smoking

Abstract: Highlights Down-regulation of CISH in OSCC tissues and cell lines. CISH mediates cellular functions through STAT3 inhibition. MiR-944 regulates cellular functions through direct binding of CISH. Cigarette smoking-mediated miR-944/CISH/STAT3 axis plays a role in oral carcinogenesis.

Cited by 34 publications

References 75 publications

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Understanding the role of potential pathways and its components including hypoxia and immune system in case of oral cancer

Tumor Suppressor miR-584-5p Inhibits Migration and Invasion in Smoking Related Non-Small Cell Lung Cancer Cells by Targeting YKT6

The role of non‐coding RNAs in drug resistance of oral squamous cell carcinoma and therapeutic potential

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