MiR-98 suppresses the effects of tumor-associated macrophages on promoting migration and invasion of hepatocellular carcinoma cells by regulating IL-10

Li, Lei; Sun, Pengfei; Zhang, Chengsheng; Li, Zongchao; Zhou, Wuyuan

doi:10.1016/j.biochi.2018.04.016

Cited by 40 publications

(27 citation statements)

References 20 publications

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“…For myeloid-derived suppressor cells (MDSCs), miR-34a can also regulate oncoprotein MUC1 and then results in the MDSC increase in acute myeloid leukemia (AML) 90 . For tumor-associated macrophages (TAMs), miR-98 directly targets the gene of interleukin 10 (IL-10) in TAMs, suppressing the progress of HCC 91 . For cancer-associated fibroblasts (CAFs), miR-21 acts a role in the metabolically altering process of CAFs thereby affects pancreatic cancer cells 92 .…”

Section: Biological Functions Of Mirna In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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MicroRNAs (miRNAs), small non-coding RNAs (ncRNAs) of about 22 nucleotides in size, play important roles in gene regulation, and their dysregulation is implicated in human diseases including cancer. A variety of miRNAs could take roles in the cancer progression, participate in the process of tumor immune, and function with miRNA sponges. During the last two decades, the connection between miRNAs and various cancers has been widely researched. Based on evidence about miRNA, numerous potential cancer biomarkers for the diagnosis and prognosis have been put forward, providing a new perspective on cancer screening. Besides, there are several miRNA-based therapies among different cancers being conducted, advanced treatments such as the combination of synergistic strategies and the use of complementary miRNAs provide significant clinical benefits to cancer patients potentially. Furthermore, it is demonstrated that many miRNAs are engaged in the resistance of cancer therapies with their complex underlying regulatory mechanisms, whose comprehensive cognition can help clinicians and improve patient prognosis. With the belief that studies about miRNAs in human cancer would have great clinical implications, we attempt to summarize the current situation and potential development prospects in this review.

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Section: Biological Functions Of Mirna In Cancermentioning

confidence: 99%

miRNA-based biomarkers, therapies, and resistance in Cancer

et al. 2020

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“…An interesting example is miR-98. This miRNA is down-modulated in melanoma progression where it plays a negative feedback loop with the pro-inflammatory IL6 [188], but it also acts as a regulator of IL10 expression in response to microbial infection or after lipopolysaccharide (LPS) stimulation [189]. Furthermore, miR-221 and -222 oncomiRs, besides a number of other functions, participate in the regulation of TLR response-inducing tolerance to microbial infection essentially through TNFα (Tumor Necrosis Factor α) degradation by regulation of Switch/Sucrose Non-Fermentable (SWI/SNF) and Signal Transducer and Activator of Transcription (STAT) [190].…”

Section: Sex Differences and Mirnasmentioning

confidence: 99%

Sex and Gender Disparities in Melanoma

Bellenghi

Puglisi

Pontecorvi

et al. 2020

Cancers

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Worldwide, the total incidence of cutaneous melanoma is higher in men than in women, with some differences related to ethnicity and age and, above all, sex and gender. Differences exist in respect to the anatomic localization of melanoma, in that it is more frequent on the trunk in men and on the lower limbs in women. A debated issue is if—and to what extent—melanoma development can be attributed to gender-specific behaviors or to biologically intrinsic differences. In the search for factors responsible for the divergences, a pivotal role of sex hormones has been observed, although conflicting results indicate the involvement of other mechanisms. The presence on the X chromosome of numerous miRNAs and coding genes playing immunological roles represents another important factor, whose relevance can be even increased by the incomplete X chromosome random inactivation. Considering the known advantages of the female immune system, a different cancer immune surveillance efficacy was suggested to explain some sex disparities. Indeed, the complexity of this picture emerged when the recently developed immunotherapies unexpectedly showed better improvements in men than in women. Altogether, these data support the necessity of further studies, which consider enrolling a balanced number of men and women in clinical trials to better understand the differences and obtain actual gender-equitable healthcare.

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“…Aberrant miRNA expression profiles (15) are regarded as a common hallmark of human cancer and are used for tumor diagnosis and prognosis due to the multiple steps of miRNA biosynthesis disorder in human cancer, including GBM (16,17). Previous studies indicate that miRNAs regulate various vital biological functions, including cell invasion, proliferation, apoptosis and angiogenesis (18-20). To the best of our knowledge, there are no previous studies on the association between miR-576-3p and glioma.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α

Liu

Yan

et al. 2019

Int J Mol Med

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The most common and aggressive type of brain cancer in adults is glioblastoma multiforme (GBM), and hypoxia is a common feature of glioblastoma. As the histological features of glioma include capillary endothelial cell proliferation, they are highly prone to invading the surrounding normal brain tissue, which is often one of the reasons for the failure of treatment. However, the mechanisms involved in this process are not fully understood. MicroRNAs (miRs) are a class of non-coding RNA that are able to inhibit the malignant progression of tumor cells through the regulation of downstream genes. In the present study, the low expression of miR-576-3p was detected in glioma samples and hypoxia-treated glioma cells using a reverse transcription-quantitative polymerase chain reaction. The present study focused on the effects of miR-576-3p on hypoxia-induced glioma. The results of the functional experiments revealed that the overexpression of miR-576-3p significantly inhibited the migration and pro-angiogenic abilities of the glioma cells under hypoxic conditions (P<0.05) compared with in the lentivirus-miR-negative control group. Furthermore, luciferase reporter gene assays were used to validate the hypothesis that miR-576-3p interacts with the 3′-untranslated region of hypoxia-inducible factor-1α (HIF-1α) and induces a reduction in the protein levels of matrix metalloproteinase-2 and vascular endothelial growth factor. Rescue experiments demonstrated that the restoration of HIF-1α expression attenuated the effect of miR-576-3p on the migration and proangiogenic abilities of glioma cells. In conclusion, the present study confirms that miR-576-3p is a novel GBM inhibitor and its inhibition of the migration and proangiogenic capacity of hypoxia-induced glioma cells is mediated by HIF-1α.

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MiR-98 suppresses the effects of tumor-associated macrophages on promoting migration and invasion of hepatocellular carcinoma cells by regulating IL-10

Cited by 40 publications

References 20 publications

miRNA-based biomarkers, therapies, and resistance in Cancer

miRNA-based biomarkers, therapies, and resistance in Cancer

Sex and Gender Disparities in Melanoma

MicroRNA‑576‑3p inhibits the migration and proangiogenic abilities of hypoxia‑treated glioma cells through hypoxia‑inducible factor‑1α

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