miR Profile of Chronic Right Ventricular Pacing: a Pilot Study in Children with Congenital Complete Atrioventricular Block

Navarre, Brittany M.; Clouthier, Katie L.; Ji, Xuhuai; Taylor, Anne L.; Weldy, Chad S.; Dubin, Anne M.; Reddy, Sushma

doi:10.1007/s12265-022-10318-w

Cited by 1 publication

(1 citation statement)

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“…Interestingly, treatments or therapeutic interventions can also affect miRNA expression profiles. Thus, compared to non-paced children, blood from chronically paced children exhibit an increased and decreased expression of 296 and 192 miRNA, respectively [22]. In conclusion, the study of miRNA is mainly descriptive and restrained to the biomarkers field in ACM.…”

Section: Arrhythmogenic Cardiomyopathymentioning

confidence: 99%

Right Ventricle and Epigenetics: A Systematic Review

Toro,

Jutras-Beaudoin,

Boucherat

et al. 2023

Cells

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There is an increasing recognition of the crucial role of the right ventricle (RV) in determining the functional status and prognosis in multiple conditions. In the past decade, the epigenetic regulation (DNA methylation, histone modification, and non-coding RNAs) of gene expression has been raised as a critical determinant of RV development, RV physiological function, and RV pathological dysfunction. We thus aimed to perform an up-to-date review of the literature, gathering knowledge on the epigenetic modifications associated with RV function/dysfunction. Therefore, we conducted a systematic review of studies assessing the contribution of epigenetic modifications to RV development and/or the progression of RV dysfunction regardless of the causal pathology. English literature published on PubMed, between the inception of the study and 1 January 2023, was evaluated. Two authors independently evaluated whether studies met eligibility criteria before study results were extracted. Amongst the 817 studies screened, 109 studies were included in this review, including 69 that used human samples (e.g., RV myocardium, blood). While 37 proposed an epigenetic-based therapeutic intervention to improve RV function, none involved a clinical trial and 70 are descriptive. Surprisingly, we observed a substantial discrepancy between studies investigating the expression (up or down) and/or the contribution of the same epigenetic modifications on RV function or development. This exhaustive review of the literature summarizes the relevant epigenetic studies focusing on RV in human or preclinical setting.

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Section: Arrhythmogenic Cardiomyopathymentioning

confidence: 99%