Mirabilis Jalapa L. Protein as Inductor of Apoptosis on UVB-induced Skin Damage in Mice

Hussaana, Atina; Sismindari,; Widyarini, Sitarina; Sudjadi,; Ikawati, Zullies

doi:10.3329/bjms.v16i3.32867

Cited by 3 publications

(2 citation statements)

References 9 publications

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“…In addition, it is possible that the bixin lotion also has an apoptotic induction mechanism which is related to the photoprotection effect as proved in the Mirabilis jalapa L leaf. 11 This needs to be clarified in further study.…”

Section: The Protection Againts Uvb-induced Immunoupressionmentioning

confidence: 96%

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

Hussaana

Suparmi

Murti

2018

Bangladesh J Med Sci

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Background: DNA damage caused by excessive ultraviolet B (UVB) radiation on the skin triggers the response to inflammatory and immunosuppression. The bixin from Bixa orellana L. has been proven to be able to inhibit cyclo-oxygenase. Objective: to verify whether the bixin lotion has the effect to offer protection against inflammation and immunosuppression due to acute UVB irradiation in shaved BALB /c mice. Methods: Protection against inflammation and immunosuppression, respectively were studied in 4 groups of mice. Each group was treated respectively with topical application of base lotion as a control; bixin lotion doses of 0.5 mg; 2.5 mg and 125 mg, for 10 days prior to and during the UVB irradiation. The Inflammation was induced by UVB irradiation, 360 mJ/cm2 once a day for 3 consecutive days, whereas the immunosuppression was induced by UVB irradiation, 360 mJ/cm2 once a day for 5 consecutive days. The inflammatory response was measured as an increase in middorsal skinfold thickness at the peak response. The immune response was measured as the contact hypersensitivity (CHS) response to oxasolon sensitization. Results: The results indicated that in concentration range used, bixin lotion significantly decreased the middorsal skinfold thickness at 72 hours after UVB radiation (p <0.05) compared to the control, but there was no significant difference between couples of the dose of bixin. Bixin lotion was also capable to restore the suppression of CHS from 34.22% in the control group to 11.4%; 0.5% and 0% at doses of 0.5; 2.5 and 125 mg respectively (p <0.05). Conclusion: Bixin lotion has the potential to reduce the inflammatory edema reaction and the suppression of CHS of mice induced by UVB radiation. Bangladesh Journal of Medical Science Vol.18(1) 2019 p.107-111

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Section: The Protection Againts Uvb-induced Immunoupressionmentioning

confidence: 96%

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

Hussaana

Suparmi

Murti

2018

Bangladesh J Med Sci

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“…The skin would then receive a UV dose associated with clearly elevated sunburn cells and skin cancer risk. 35…”

Section: Effects Of Uvb Radiation Dosage To Vitamin Dmentioning

confidence: 99%

UVB Dose Optimization for Phototherapy in Vitamin D Deficiency : Profile Analysis of Vitamin D, TNF-α, Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF) in Wistar Rats

Arsita

Nasihun

Hussaana³

2020

Bangladesh J Med Sci

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Background : UVB radiation responsible for the most important biological effects including Vitamin D3 synthesis and inflammation. UVB radiation are absorbed by 7-dehydrocholesterol in the plasma membrane of epidermal cells resulting in production of cis-previtamin D3. In the other hand, an exposure to UVB leads to cutaneous tissue inflammation modulates by TNF-α which also increases platelet activating factor. VEGF and PDGF induced by TNF-α during wound healing, characterized with angiogenesis and reephitalization. Furthermore, vitamin D plays a role in inflammation inhibition and upregulates growth factors. However, the study of the mechanism has not yet been thoroughly investigated. Methods: This study uses post test only group design, subjected wistar rats divided into four groups. Control group, non irradiated with UVB, and the other three groups, treated with graded UVB dose started with 1 MED (50 mJ/cm2), 2 MED (100mJ/cm2) and 3 MED (150 mJ/cm2) and investigated at 6, 12, 24 and 48 hours post UVB irradiation. Result : The serum level of vitamin D, VEGF and PDGF were increasing due to UVB dose addition. The highest level was reached at 6 hours post radiation using 3 MED, which gradually decrease up to 48 hours (p =0,000). The rise of vitamin D after UVB radiation, inhibit TNF-α induction in every dose accordant UVB dose addition and the lowest level is using 3 MED at 12 hours post radiation (p =0,000). TNF-α reach its highest level at 24 hours post radiation using 1 MED, it is related with the acute phase of inflammation. Conclusion : This study reveal that higher UVB irradiance increases vitamin D and inhibit TNF-α which also promotes VEGF and PDGF. Bangladesh Journal of Medical Science Vol.19(4) 2020 p.749-754

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Principles and Applications of Ethnobotany in Modern Skincare

Yadav,

Choudhary

2024

Advances in Chemical and Materials Engineering

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Ethnobotany studies human‒plant interactions, focusing on plant use for treating and preventing illnesses in humans and animals. It delves into indigenous knowledge, cultural practices, and religious rituals related to medicinal plants. Historical evidence from Egypt, Babylon, India, and China highlights the extensive use of plant-based remedies. For example, the Ebers Papyrus and Ayurvedic texts detail ancient treatments. The Amazon rainforest provides plants such as Andiroba and Copaifera for skincare, whereas Chinese medicine uses herbs such as Chinese knotweed and star anise. Ancient Egyptians employed plants such as marshmallows and pomegranates. Ayurveda in India utilizes neem and turmeric, and Nigeria's flora includes garlic and bitter orange for traditional skincare. This highlights the crucial role of plants across cultures, reflecting a rich heritage of ethnobotanical knowledge informing modern practices.

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Mirabilis Jalapa L. Protein as Inductor of Apoptosis on UVB-induced Skin Damage in Mice

Cited by 3 publications

References 9 publications

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

Protective Effect of Bixin Isolated from Bixa orellana L. Seeds on UVB-Induced Inflammation and Immunosuppression of the Skin

UVB Dose Optimization for Phototherapy in Vitamin D Deficiency : Profile Analysis of Vitamin D, TNF-α, Vascular Endothelial Growth Factor (VEGF) and Platelet Derived Growth Factor (PDGF) in Wistar Rats

Principles and Applications of Ethnobotany in Modern Skincare

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