Miracle cells for natural dentistry – A review

Abstract

Stem cells are undifferentiated cells that can differentiate into specialized cells. Recently, enormous growth has been seen in the recognition of stem cell-based therapies, which have the potential to ameliorate the life of patients with conditions that span from Parkinson's disease to cardiac ischemia to bone or tooth loss. This research has produced new but unexplored possibilities in the regeneration of different organs and tissues. Presently, research is focused on the proficiency of stem cells and their utilization in dentistry, which is gaining interest. The tooth is nature's "esteem" for these precious stem cells and there are a number of these cells in permanent and primary teeth, as well as in the wisdom teeth. Dental stem cells are easy, convenient, and affordable to collect. They hold promise for a range of very potential therapeutic applications, such as in the treatment of cancer, spinal cord injury, brain damage, myocardial infarction, hearing loss, diabetes, wound healing, baldness, etc. Since these cells were used to regenerate damaged tissue in medical therapy successfully, it is possible that the dentist in future might use stem cell to regenerate lost or damaged dental and periodontal structures. This paper reviews the current concepts, characteristics of stem cells in regeneration, and its subsequent uses in dentistry.

Effects and mechanism of stem cells from human exfoliated deciduous teeth combined with hyperbaric oxygen therapy in type 2 diabetic rats

“…Dental pulp MSCs have been studied in animal models of different diseases (2), including systemic lupus erythematosus, ischemic brain injury, spinal cord injury, and muscular atrophy. Stem cells from human exfoliated deciduous teeth (SHED) were shown to differentiate into insulin-secreting cells in vitro (3), and may be potentially useful for the treatment of glucose metabolic disorders.…”

Advanced Biomaterials and Techniques for Oral Tissue Engineering and Regeneration—A Review

“…Studies on TGPCs have demonstrated their high proliferation activity and capacity to differentiation into adipogenic, chondrogenic, osteogenic, odontogenic, and neurogenic tissue [ 28 , 29 ]. In addition, TGPCs can differentiate into hepatocytes in vitro [ 25 , 30 ] and are able to form tube-like structures, possibly evidence of vascularization [ 31 ]. Stem cells of human exfoliated deciduous teeth (SHEDs), obtained from exfoliated deciduous teeth, have higher proliferation capacity than DPSCs and the capability to differentiate into many more different body tissues than other types of SCs, including into adipocytes, osteoblasts, odontoblasts, neural cells, hepatocytes, and endothelial cells.…”

“…SCs collected from postnatal tooth buds of animals, self-replicated and differentiated in vitro, have been seeded onto a biodegradable scaffold. Their in vivo maturation was achieved by transplanting the seeded scaffolds either into the renal capsule or the omentum, followed by their reimplantation into an extracted tooth place or the jaw [ 31 ]. However, by using non-human cells, the chance of immune rejection exists [ 306 ].…”

“…Studies on TGPCs have demonstrated their high proliferation activity and capacity to differentiation into adipogenic, chondrogenic, osteogenic, odontogenic, and neurogenic tissue [28,29]. In addition, TGPCs can differentiate into hepatocytes in vitro [25,30] and are able to form tube-like structures, possibly evidence of vascularization [31].…”