Mirazid: A New Schistosomicidal Drug

Further assessment of Mirazid as antischistosomal drug in experimental schistosomiasis hematobium

“…These studies dealt with experimental animals and patients and showed that the cure rate ranged from 91.7% to 97.4% (Massoud, 1999a(Massoud, , 1999b(Massoud, , 1999cBadria et al, 2001;Sheir et al, 2001;El Baz et al, 2003;AboMadyan et al, 2004;Massoud et al, 2004Massoud et al, , 2005Soliman et al, 2004).…”

“…(Burseraceae) (Badria et al, 2001). Since 2001 this compound has been marketed and claimed a safe effective natural product (Massoud, 1999a(Massoud, , 1999b(Massoud, , 1999cBadria et al, 2001;Sheir et al, 2001;El Baz et al, 2003;Abo-Madyan et al, 2004;Massoud et al, 2004Massoud et al, , 2005, possessing antischistosomal activity against Schistosoma mansoni (Sambon, 1907) and S. hematobium with high therapeutic index. Botros et al (2004) reported that LD 50 value of acute toxicity for this drug was 3,139 mg/kg.…”

Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs

“…There have been reports that myrrh, the resinous dried sap of the plant Commiphora myrrha, has schistosomicidal activity in experimental animals (Badria et al 2001) and humans (Sheir et al 2001). Independent evaluations of myrrh in experimental animals ) and humans (Barakat, Elmorshedy and Fenwick, 2005 ;Botros et al 2005 c) have however found very little evidence for such activity and this product should therefore be removed from the market for schistosomicides.…”

Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challenges

“…However, it has been attributed to permanent loss of musculature of the worms leading to uncoupling of male and female couples and their shift to the liver where destruction takes place (Badria et al 2001). A recent study on the in vitro effect of myrrh on S. mansoni revealed that the tegument of the worm appeared markedly edematous with extensive disruption of the interpapillary areas and sensory bulbs.…”

“…Badria et al (2001) reported significant parasite reductions of 76% and 75% after treatment of S. mansoniinfected mice with 250 and 500 mg/kg of the myrrh special preparation "Mirazid®" twice a day for 3 days. Moreover, uncoupling of worms and hepatic shift of female worms, with a decrease in the number of immature eggs in the wall of small intestine accompanied with an increase in the percentage of mature stages, indicated the schistosomicidal activity of the drug.…”