miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway

Ye, Zi; Li, Zhaohui; He, Song

doi:10.12659/msm.905336

Cited by 23 publications

(14 citation statements)

References 32 publications

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“…lncRNAs and miRNAs were previously demonstrated to be associated with the pathogenesis of DR (10–12). Previous findings highlight that the development of DR is associated with various key molecules, such as miR-1273g-3p, miR-21 and miR-29a (13–15). Research has elucidated how miRNAs play a pivotal role in the diagnosis of DR (16).…”

Section: Introductionmentioning

confidence: 99%

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

Jia

et al. 2018

Mol Med Report

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Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA-miRNA-mRNA interactions in DR are poorly understood. In the present study, we aimed to compute a global triple network of competitive endogenous RNAs (ceRNAs) in order to pinpoint essential molecules. We found that there were 802 nodes (121 lncRNA nodes, 17 miRNA nodes, and 664 mRNA nodes) and 949 edges in the ceRNA network. Further functional analysis suggested that some molecules were specifically related to DR. Surprisingly, these molecules were involved in visual perception, eye development, and lens development in camera-type eye. In summary, our study highlighted specific lncRNAs and miRNAs related to the pathogenesis of DR, which might be used as potential diagnostic biomarkers and therapeutic targets for DR.

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Section: Introductionmentioning

confidence: 99%

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

Jia

et al. 2018

Mol Med Report

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“…High expression of miR-1273g-3p has been found in RPE cells extracted from retinas of diabetic rats ( 109 ). MiR-1273g-3p mimic enhanced the expression of DR-related MMP-2, MMP-9, and TNF-α proteins, and autophagy-related LC3II/I, cathepsin B, and cathepsin L factors, while miR-1273g-3p inhibitor could downregulate the levels of these factors.…”

Section: The Detrimental Role Of Autophagy In Diabetic Retinopathymentioning

confidence: 99%

Protective or Harmful: The Dual Roles of Autophagy in Diabetic Retinopathy

Gong

Wang

et al. 2021

Front. Med.

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Autophagy is a self-degradative pathway involving intracellular substance degradation and recycling. Recently, this process has attracted a great deal of attention for its fundamental effect on physiological processes in cells, tissues, and the maintenance of organismal homeostasis. Dysregulation of autophagy occurs in some diseases, including immune disease, cancer, and neurodegenerative conditions. Diabetic retinopathy (DR), as a serious microvascular complication of diabetes, is the main cause of visual loss in working-age adults worldwide. The pathogenic mechanisms of DR are thought to be associated with accumulation of oxidative stress, retinal cell apoptosis, inflammatory response, endoplasmic reticulum (ER) stress, and nutrient starvation. These factors are closely related to the regulation of autophagy under pathological conditions. Increasing evidence has demonstrated the potential role of autophagy in the progression of DR through different pathways. However, to date this role is not understood, and whether the altered level of autophagy flux protects DR, or instead aggravates the progression, needs to be explored. In this review, we explore the alterations and functions of autophagy in different retinal cells and tissues under DR conditions, and explain the mechanisms involved in DR progression. We aim to provide a basis on which DR associated stress-modulated autophagy may be understood, and to suggest novel targets for future therapeutic intervention in DR.

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“…Also, using miR‐153‐3p triggers ATG5—another autophagy mediator—and decreases autophagy in order to improve response in gefitinib‐resistant nonsmall cell lung cancer (NSCLC) patients 60 . The miR‐1273g‐3p role in diabetic retinopathy (DR) also makes it potential target in DR treatment 61 …”

Section: Autophagy and Mirnasmentioning

confidence: 99%

Autophagy regulation by microRNAs: Novel insights into osteosarcoma therapy

et al. 2020

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Osteosarcoma (OS) is a kind of primary bone cancer that is considered as the leading cause of children death. Surgery and chemotherapy are considered as common treatment approaches for OS; the rate of survival for patients is almost 60-70%. Besides the used therapeutic approaches, it seems that there is a crucial need to launch new treatments for OS. In this regard, more understanding about cellular and molecular pathways involved in OS can contribute to recovery and develop new therapeutic platforms. Autophagy is a cellular machinery that digests and degrades dysfunctional proteins and organelles, so it can regulate the cell proliferation and survival. Most of the time, OS cells use autophagy to increase their survival and proliferation and to gain the ability to resist chemotherapy. Although, there are several controversial evidences on how OS cells use autophagy. A variety of cellular and molecular pathways, that is, microRNAs (miRNAs) can modulate autophagy. MiRNAs are some endogenous, approximately 22 nucleotide RNAs that have an important role in posttranscriptional regulation of mRNAs by targeting them. There are many evidences that the various miRNA expressions in OS cells are dysregulated, so it can propel a normal cell to cancerous one by influencing the cell survival, apoptosis, and autophagy, and eventually increased chemoresitance. Hence, miRNAs can be considered as new biomarkers for OS diagnosis, and according to the role of autophagy in OS progression, miRNAs can use inhibiting or promoting autophagy agents. The present review summarizes the effects of

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miRNA-1273g-3p Involvement in Development of Diabetic Retinopathy by Modulating the Autophagy-Lysosome Pathway

Cited by 23 publications

References 32 publications

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

A comprehensive competitive endogenous RNA network pinpoints key molecules in diabetic retinopathy

Protective or Harmful: The Dual Roles of Autophagy in Diabetic Retinopathy

Autophagy regulation by microRNAs: Novel insights into osteosarcoma therapy

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