miRNA-21 promotes renal carcinoma cell invasion in a microfluidic device

Abstract

MicroRNAs (miR) play important roles in cancer invasion.

MiRNA-873-5p Acts as a Potential Novel Biomarker and Promotes Cervical Cancer Progression by Regulating ZEB1 via Notch Signaling Pathway

“…With enormous successes of next-generation sequencing and bioinformatics technology, growing miRNAs were identified to be important modulators in various tumors. 32 , 33 Recently, several studies have reported the expression and function of miRNA-873-5p in several types of cancers. For instance, Gao et al 34 revealed that miRNA-873 was highly expressed in lung adenocarcinoma and its forced upregulation resulted in the promotion of the abilities in the metastasis of lung adenocarcinoma cells via controlling SRCIN1.…”

The Ambivalent Role of miRNAs in Carcinogenesis: Involvement in Renal Cell Carcinoma and Their Clinical Applications

“…MiR-21 correlates with growth, apoptosis modulation and cell cycle progression of RCC cells [ 57 ]. In addition, Wang and colleagues demonstrate the association between high expression levels of miR-21 and the major invasive ability of RCC cell lines and primary cancer cells compared to human renal tubular epithelial (HK2) cells [ 58 ].…”

Precise Engineering of Cisplatin Prodrug Into Supramolecular Nanoparticles: Enhanced on in Vitro Antiproliferative Activity and Treatment and Care of in Vivo Renal Injury 

“…Renal cell carcinoma (RCC) is not a single organism but rather a group of tumors that arise from the highly heterogeneous epithelium of kidney tissue [1][2][3][4][5]. According to the Heidelberg description of renal cell cancer, histopathological subtypes of RCC includes clear cell adenocarcinoma, the most prevalent form of RCC, chromophobe accumulating duct carcinoma, papillary carcinoma, and unclassi ed carcinoma [6][7][8][9][10]. Among urological tumors, RCC has the highest risk of cancer-speci c mortality and the 5-year survival rate for patients with metastatic disease is just 12%.…”