2016
DOI: 10.21037/sci.2016.10.04
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miRNA-324, a potential therapeutic target for paracetamol-induced liver injury

Abstract: Paracetamol is one of the most widely used medications for relieving pain and fever. When taken in the therapeutic doses, paracetamol is predominantly metabolized in the liver via conjugation reaction by phase II drug metabolizing enzymes such as sulfotransferases and glucuronyl transferases, and is removed from the body without liver damage (1). However, when paracetamol is taken in excessive doses, it is bioactivated by phase I enzymes (e.g., CYP3A4 and CYP2E1) to generate a toxic intermediate N-acetyl-p-ben… Show more

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“…miRNAs can directly bind the 3′-untranslated region of target genes leading to inhibition in gene expression ( 11 ). Emerging studies report that miRNAs serve important regulatory roles in tumor progression making them potential therapeutic targets in various human cancers, such as lung and liver cancer ( 12 , 13 ). Notably, some aberrantly expressed miRNAs have also been detected in PCa, such as miR-215-5p ( 14 ) and miR-145 ( 15 ), which participate in disease pathogenesis and are associated with the prognosis of PCa.…”
Section: Introductionmentioning
confidence: 99%
“…miRNAs can directly bind the 3′-untranslated region of target genes leading to inhibition in gene expression ( 11 ). Emerging studies report that miRNAs serve important regulatory roles in tumor progression making them potential therapeutic targets in various human cancers, such as lung and liver cancer ( 12 , 13 ). Notably, some aberrantly expressed miRNAs have also been detected in PCa, such as miR-215-5p ( 14 ) and miR-145 ( 15 ), which participate in disease pathogenesis and are associated with the prognosis of PCa.…”
Section: Introductionmentioning
confidence: 99%