miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes

Fotoh, Dina Salem; Noreldin, Rasha I.; Rizk, Mohamed S.; Elsabaawy, Maha; Esaily, Heba A.

doi:10.1155/2020/2180913

Cited by 9 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To date, many attempts to screen biomarkers of AS have been made. Based on miRNA-451a and miRNA-125a expression levels ( 56 ) and collagen protein of serum samples ( 57 ), the models generally achieved the performance of AUCs between 0.60 to 0.80. Herein, we obtained a more accurate and higher AUC of 0.868, 0.895, and 0.893 using only 1004 gut vOTUs.…”

Section: Discussionmentioning

confidence: 99%

Alterations in the gut virome in patients with ankylosing spondylitis

Zhang

Yan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

IntroductionAnkylosing spondylitis (AS), a chronic autoimmune disease, has been linked to the gut bacteriome.MethodsTo investigate the characteristics of the gut virome in AS, we profiled the gut viral community of 193 AS patients and 59 healthy subjects based on a metagenome-wide analysis of fecal metagenomes from two publicly available datasets.ResultsAS patients revealed a significant decrease in gut viral richness and a considerable alteration of the overall viral structure. At the family level, AS patients had an increased abundance of Gratiaviridae and Quimbyviridae and a decreased abundance of Drexlerviridae and Schitoviridae. We identified 1,004 differentially abundant viral operational taxonomic units (vOTUs) between patients and controls, including a higher proportion of AS-enriched Myoviridae viruses and control-enriched Siphoviridae viruses. Moreover, the AS-enriched vOTUs were more likely to infect bacteria such as Flavonifractor, Achromobacter, and Eggerthellaceae, whereas the control-enriched vOTUs were more likely to be Blautia, Ruminococcus, Collinsella, Prevotella, and Faecalibacterium bacteriophages. Additionally, some viral functional orthologs differed significantly in frequency between the AS-enriched and control-enriched vOTUs, suggesting the functional role of these AS-associated viruses. Moreover, we trained classification models based on gut viral signatures to discriminate AS patients from healthy controls, with an optimal area under the receiver operator characteristic curve (AUC) up to 0.936, suggesting the clinical potential of the gut virome for diagnosing AS.DiscussionThis work provides novel insight into the AS gut virome, and the findings may guide future mechanistic and therapeutic studies for other autoimmune diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Alterations in the gut virome in patients with ankylosing spondylitis

Zhang

Yan

et al. 2023

Front. Immunol.

View full text Add to dashboard Cite

show abstract

“…[ 30 ] miR‐21 and miR‐126 can be used as novel diagnostic biomarkers for acute coronary syndrome. [ 31 ] Notably, some miRNAs, such as miR‐214, [ 22 ] miR‐451a, and miR‐125a [ 32 ] have been demonstrated to be used as diagnostic biomarkers for AS patients. This study demonstrated the high diagnostic value of miR‐222‐3p to screen AS patients from healthy subjects and RA patients.…”

Section: Discussionmentioning

confidence: 99%

Circulating miR‐222‐3p is associated with ankylosing spondylitis development and predicts therapeutic efficacy of nonsteroidal anti‐inflammatory drugs

Jiang¹,

Wang²,

et al. 2023

J Biochem & Molecular Tox

View full text Add to dashboard Cite

Ankylosing spondylitis (AS) is a chronic rheumatic disease, and some microRNAs (miRNAs) in AS have been identified. This study aimed to measure miR‐222‐3p expression in AS patients, investigate the association of miR‐222‐3p with AS disease activity, and explore the clinical value of miR‐222‐3p in diagnosing AS and predicting therapeutic efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) on AS patients. This study included 96 patients with AS, 58 patients with rheumatoid arthritis (RA), and 90 healthy controls. miR‐222‐3p expression was detected by reverse‐transcription quantitative polymerase chain reaction (PCR). The ability of miR‐222‐3p to discriminate between different groups was evaluated by receiver operating characteristic analysis. The predictive value of miR‐222‐3p on the efficacy of NSAID treatment for AS was assessed by logistic regression analysis. AS patients treated with oral NSAIDs diclofenac sodium were divided into response (n = 76) and no‐response (n = 20) groups after 16 weeks of treatment. miR‐222‐3p in AS patients was higher than that in healthy subjects and RA patients. miR‐222‐3p had high diagnostic value in distinguishing patients with AS from RA patients and healthy controls. miR‐222‐3p, increased in active AS patients, had the ability to screen active AS patients from inactive AS patients. miR‐222‐3p was decreased in the response group, and had high accuracy in predicting the therapeutic efficiency of NSAIDs. The findings indicate that increased miR‐222‐3p in AS patients may function as a diagnostic biomarker for AS, and predictive biomarker for the therapeutic efficacy of NSAIDs in patients with AS. In addition, miR‐222‐3p is associated with AS disease activity.

show abstract

“…Due to these limitations, further studies involving various age ranges and female subjects are required to gain further insights into this disease. miRNA profiling has been used as a diagnostic tool for several diseases [31][32][33][34] . We evaluated miRNAs in skin biopsy samples comprising epidermal and dermal tissues.…”

Section: Discussionmentioning

confidence: 99%

Differential microRNA profiles in elderly males with seborrheic dermatitis

Kim

Yun

Baek

et al. 2022

Sci Rep

View full text Add to dashboard Cite

Seborrheic dermatitis (SD) is one of the most common skin diseases characterized by inflammatory symptoms and cell proliferation, which has increased incidence in patients older than 50 years. Although the roles of microRNAs (miRNAs) have been investigated in several diseases, miRNA profiles of patients with SD remain unknown. This study aimed to identify differentially expressed miRNAs (DEMs) in lesions of elderly male patients with SD. We used a microarray-based approach to identify DEMs in lesions compared to those in non-lesions of patients with SD. Furthermore, Gene Ontology and pathway enrichment analysis were performed using bioinformatics tools to elucidate the functional significance of the target mRNAs of DEMs in lesions of patients with SD. Expression levels of two miRNAs—hsa-miR-6831-5p and hsa-miR-7107-5p—were downregulated, whereas those of six miRNAs—hsa-miR-20a-5p, hsa-miR-191-5p, hsa-miR-127-3p, hsa-miR-106b-5p, hsa-miR-342-3p, and hsa-miR-6824-5p—were upregulated. Functions of the SD-related miRNAs were predicted to be significantly associated with typical dermatological pathogenesis, such as cell proliferation, cell cycle, apoptosis, and immune regulation. In summary, SD alters the miRNA profile, and target mRNAs of the DEMs are related to immune responses and cell proliferation, which are the two main processes in SD pathogenesis.

show abstract

miRNA-451a and miRNA-125a Expression Levels in Ankylosing Spondylitis: Impact on Disease Diagnosis, Prognosis, and Outcomes

Cited by 9 publications

References 30 publications

Alterations in the gut virome in patients with ankylosing spondylitis

Alterations in the gut virome in patients with ankylosing spondylitis

Circulating miR‐222‐3p is associated with ankylosing spondylitis development and predicts therapeutic efficacy of nonsteroidal anti‐inflammatory drugs

Differential microRNA profiles in elderly males with seborrheic dermatitis

Contact Info

Product

Resources

About