miRNA-641 Inhibits the Proliferation, Migration, and Invasion and Induces Apoptosis of Cervical Cancer Cells by Directly Targeting ZEB1 [Retraction]

Yao, Rui; Zheng, Huzhong; Wu, Liqun; Cai, Ping

doi:10.2147/ott.s339845

Cited by 2 publications

(2 citation statements)

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“…miRNA-641 (miR-641) exhibited an essential role in lung cancer, cervical carcinoma, and glioblastoma [13][14][15]. However, its mechanism in the EC cells remain unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1

Dong

Hua

2022

Evidence-Based Complementary and Alternative Medicine

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MicroRNA-641 (miR-641) was significantly decreased in various cancers, but its roles in endometrial cancer (EC) remain unclear. We explored the influences of miR-641 on the EC cells. In our study, the miR-641 expression was reduced in EC cells. Overexpression of miR-641 inhibited viability and proliferation of HEC-1A and HECCL-1 cells by CCK-8 and colony formation assays. Additionally, flow cytometry revealed that overexpression of miR-641 could remarkably promote apoptosis and arrest the cell cycle at the G1 phase of HEC-1A and HECCL-1 cells. Besides, forced expression of miR-641 suppressed the migration and invasion of HEC-1A and HECCL-1 cells as evidenced by wound healing and transwell assay. Moreover, AP1G1 was confirmed as a target gene of miR-641 by StarBase prediction and DLR assay and their expressions were negatively correlated. Overexpression of AP1G1 neutralized the roles of miR-641 mimic on the viability, proliferation, apoptosis, and migration of HEC-1A and HECCL-1 cells. Our findings illustrated that miR-641 was reduced in the EC cells and AP1G1 antagonized the miR-641 mimic-induced inhibition of the EC progression in vitro. Therefore, miR-641 may emerge as an effective molecule for EC treatment.

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“…miRNA-641 (miR-641) exhibited an essential role in lung cancer, cervical carcinoma, and glioblastoma [13][14][15]. However, its mechanism in the EC cells remain unknown.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1

Dong

Hua

2022

Evidence-Based Complementary and Alternative Medicine

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“…In recent years, substantial dysregulated miRNAs with important regulatory effects have been found in cervical cancer cell lines and tissues [13][14][15]. MiRNAs exert effects on all biological behaviours of cervical cancer onset and development, including apoptosis, proliferation, invasion, migration, and drug resistance [16][17][18]. For example, miR-20b enhances the invasive ability of cervical cancer cells by upregulating EMT [19].…”

Section: Discussionmentioning

confidence: 99%

MiR-1254 suppresses the proliferation and invasion of cervical cancer cells by modulating CD36

Zhang

Yang

et al. 2022

J Transl Med

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Background This study aimed to elucidate the roles of miR-1254 in cervical cancer progression and to explore the underlying mechanisms. Methods The expression levels of miR-1254 in normal-cancer cervical tissues and cells were measured using quantitive real-time polymerase chain reaction (qRT-PCR). The invasive and proliferative abilities of cervical cancer cell lines transfected with negative control (NC) mimic or miR-1254 mimic were measured using transwell, CCK-8, and colony formation assays. The binding sites between CD36 and miR-1254 were determined using luciferase reporter assays. The correlation of CD36 and miR-1254 with cervical cancer development was re-confirmed by co-transfection of miR-1254 mimic and CD36 overexpression using CCK-8, colony formation, transwell and western blot assays. Results MiR-1254 was expressed at significantly lower levels in the cervical cancer cell lines and tissues than in the controls. The functional assays revealed that upregulation of miR-1254 inhibited the invasion and proliferation of cervical cancer cells. The luciferase reporter assays demonstrated that CD36 messenger RNA and miR-1254 bound to one another. CD36 overexpression reversed the inhibitory effects of upregulated miR-1254 in the cervical cancer cells, suggesting that miR-1254 regulates cervical cancer progression by modulating CD36. Conclusion miR-1254 attenuated the invasion and proliferation of cervical cancer cells by modulating the expression levels of CD36.

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miRNA-641 Inhibits the Proliferation, Migration, and Invasion and Induces Apoptosis of Cervical Cancer Cells by Directly Targeting ZEB1 [Retraction]

Cited by 2 publications

References 0 publications

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1

MiR-1254 suppresses the proliferation and invasion of cervical cancer cells by modulating CD36

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