miRNA as potential biomarkers after liver transplantation: A systematic review

Koch, Pia F.; Ludwig, Kristina; Krenzien, Felix; Hillebrandt, Karl H.; Schöning, Wenzel; Pratschke, Johann; Raschzok, Nathanael; Sauer, Igor M.; Moosburner, Simon

doi:10.1016/j.trre.2024.100831

Transplantation Reviews

2024

DOI: 10.1016/j.trre.2024.100831

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miRNA as potential biomarkers after liver transplantation: A systematic review

Pia F. Koch,

Kristina Ludwig,

Felix Krenzien

et al.

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2024

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The Pre-/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT

Chiu,

Lin,

et al. 2024

CIMB

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This study aimed to investigate the relationship between the IL-28B SNP rs8099917 genotype, miRNA-122 expression, and the immune mechanism of ACR after LT using anti-HCV antibody calibration. A total of 45 patients with HCV received LT. IL-28B SNP rs8099917 genotyping was used to divide patients into TT and GT groups. The relative expression levels of miRNA-122 were calculated by quantitative PCR. Anti-HCV titers before and after LT were tracked to observe the relationship with ACR. The ACR rates were 27.6% for genotype TT and 62.5% for genotype GT, indicating a significantly higher rate in the GT group compared to the TT group (p = 0.024). In the rs8099917 genotype, TT was significantly associated with higher serum miRNA-122 levels than GT (p < 0.001). The TT group had significantly better outcomes than the GT group (p = 0.005). The Mann–Whitney U test showed significant differences in pre-LT and post-LT anti-HCV titers between the IL-28B genotypes (TT and GT) (p values of 0.006 and 0.027, respectively). These results suggested that the IL-28B rs8099917 genotype TT may play a significant role in modulating immune responses, both in terms of anti-HCV titers and the risk of ACR, possibly mediated through miRNA-122 levels.

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The Pre-/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT

Chiu,

Lin,

et al. 2024

CIMB

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miRNA as potential biomarkers after liver transplantation: A systematic review

Cited by 1 publication

References 35 publications

The Pre-/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT

The Pre-/Post-Transplant Hepatitis C Antibody Associated with the IL-28B RS8099917 TT Genotype and miRNA-122 Expression May Protect Acute Cellular Rejection After LDLT

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