2021
DOI: 10.1039/d0ra10733f
|View full text |Cite
|
Sign up to set email alerts
|

miRNA-mediated alteration of sulfatase modifying factor 1 expression using self-assembled branched DNA nanostructures

Abstract: Reduced expression of SUMF1 was evidenced in MCF-7 cells transfected with antimiR-bDNA. Expression of miRNA-106 and 148 have positive correlation with the expression of SUMF1. miRNA-106 and 148 blocks the repressor protein controls SUMF-1 expression.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3

Citation Types

0
3
0

Year Published

2022
2022
2024
2024

Publication Types

Select...
5
3

Relationship

3
5

Authors

Journals

citations
Cited by 11 publications
(3 citation statements)
references
References 50 publications
0
3
0
Order By: Relevance
“…Guttilla and White [11], demonstrated the downregulation of oncomiRs by administration of antimiRNAs and reported the overexpression of FOXO1 in MCF7 cell line. Recently, selfassembled branched DNA (bDNA) nanostructures have been evolved as economic and efficient strategy for miRNA-based cancer therapy [14][15][16][17][18][19][20]. Previously, our group has also reported the synergistic downregulation of oncomiRs and upregulation of FOXO1 by antimiR-bDNA nanostructures which selectively binds to the oncomiRs 27a, 96 and 182 in MCF-7 cell line [21].…”
Section: Introductionmentioning
confidence: 99%
“…Guttilla and White [11], demonstrated the downregulation of oncomiRs by administration of antimiRNAs and reported the overexpression of FOXO1 in MCF7 cell line. Recently, selfassembled branched DNA (bDNA) nanostructures have been evolved as economic and efficient strategy for miRNA-based cancer therapy [14][15][16][17][18][19][20]. Previously, our group has also reported the synergistic downregulation of oncomiRs and upregulation of FOXO1 by antimiR-bDNA nanostructures which selectively binds to the oncomiRs 27a, 96 and 182 in MCF-7 cell line [21].…”
Section: Introductionmentioning
confidence: 99%
“…[11], demonstrated the downregulation of oncomiRs by administration of antimiRNAs and reported the overexpression of FOXO1 in MCF7 cell lines. Recently, self-assembled branched DNA (bDNA) nanostructures have been evolved as economic and e cient strategy for miRNA-based cancer therapy [14][15][16][17][18][19][20]. Recently, our group has also reported the synergistic downregulation of oncomiRs and upregulation of FOXO1 by antimiR-bDNA nanostructures which selectively binds to the oncomiRs 27a, 96 and 182 in MCF-7 cells [21].…”
Section: Introductionmentioning
confidence: 99%
“…The critical role of SUMF1 in steroid sulfate hydrolysis and therefore in estradiol level, suggests its oncogenic role. Recently, we have shown the effect of ectopic expression of SUMF1 on breast cancer cell proliferation [11]. High expression in tumor tissues and its direct involvement in estrogen level highlight the importance of studying the possible strategies that can target its activity.…”
Section: Introductionmentioning
confidence: 99%