miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review

Valencia-Quintana, Rafael; Bahena, Iván; Castañeda, Gerardo González; González, Edmundo Bonilla; Milić, Mirta; Bonassi, Stefano; Sánchez-Alarcón, Juana

doi:10.1016/j.chemosphere.2022.133792

Cited by 10 publications

(4 citation statements)

References 111 publications

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“…In addition to the use of ecotoxicity, cytotoxicity and genotoxicity tests with the aim of assessing the potential risks from contact with pesticides at different levels of biological organization [ 52 ], the application of new molecular approaches to contribute to the elucidation of possible mechanisms through which pesticides induce different diseases, including cancer, is recommended. Deregulation of miRNAs expression (let-7, miR-9, miR-21, miR-30, miR-126 miR-155, miR-181, miR-223, miR-363 and miR-320), has been evaluated to be a leading biomarker in evaluating the response to pesticide exposure [ 53 ]. Some of these miRNAs are essential for cellular proliferation, differentiation and transformation or are targets of tumor repressors and have an essential role in cancer development [ 53 , 54 ].…”

Section: Discussionmentioning

confidence: 99%

“…Deregulation of miRNAs expression (let-7, miR-9, miR-21, miR-30, miR-126 miR-155, miR-181, miR-223, miR-363 and miR-320), has been evaluated to be a leading biomarker in evaluating the response to pesticide exposure [ 53 ]. Some of these miRNAs are essential for cellular proliferation, differentiation and transformation or are targets of tumor repressors and have an essential role in cancer development [ 53 , 54 ]. Improving understanding of miRNA deregulation by pesticide contact will permit their proposal as biomarkers, which could improve knowledge of the molecular toxicity of pesticides.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Pesticide Exposure over DNA Damage in Farmers from Los Reyes, Michoacan in Mexico

Valencia-Quintana

Milić

Bonassi

et al. 2023

Toxics

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In the municipality of Los Reyes, Michoacán, in Mexico, several economic activities coexist; however, the most relevant is agriculture. It stands out as an agro-industrial center and commercial enclave in the region, suitable for the cultivation of sugar cane; however, currently fruit growing takes first place with blackberry, raspberry and blueberry, followed by avocado, peach, strawberry and other crops. A large quantity and variety of pesticides are applied to crops, consequently the population is at constant risk. This study aimed to evaluate whether pesticides are a factor in genetic damage to agricultural workers from Los Reyes, Michoacán, using alkaline comet assay. Fifty-nine residents participated (41 workers and 18 controls). Results included confounding factors (alcohol consumption, smoking habit, gender, age, BMI, etc.) indicated a non-significant statistical difference between two groups, with higher DNA damage values in workers that was higher than the values expected in a normal healthy unexposed population. It seems that the control measures, safe handling of pesticides and quality standards, required by the producers so that their products can be exported, have resulted in less damage, despite workers’ activity, but higher damage than the reference values still requires regular surveillance of those exposed. The use of protective equipment or measures can reduce the risk of damage, so it is also necessary to promote their service and comply with labor regulations for agricultural workers.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of Pesticide Exposure over DNA Damage in Farmers from Los Reyes, Michoacan in Mexico

Valencia-Quintana

Milić

Bonassi

et al. 2023

Toxics

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“…E.g. miR-21-3p is significantly increased in COVID-19 patients compared to healthy controls [16], and miR-181 family members are involved in inflammation regulation [17] and are considered as therapeutic targets due to their protective effects when down regulated [18], e.g. by quercetin [19].…”

Section: Mirnas Reflect the Host -Virus Interaction: Micrornasmentioning

confidence: 99%

Epigenetic active phytoceuticals activate immune relevant miRNAs important in virus response systems

Haslberger

2022

FFHD

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Background: Viruses significantly affect global health. The few available viricidal and antiviral therapies are expensive and often associated with unwanted side effects. Functional foods as plant extracts (nutraceuticals) are epigenetically active, and multi-target antiviral compounds that affect several steps of the viral life cycle and host proteins. MicroRNAs (miRNAs) post-transcriptionally regulate host and viral gene expression and are responsible for the fine-tuning of gene expression by controlling the expression of their target messenger RNAs (mRNA) in host cells and viruses. Several plant ingredients have been proven to be active against RNA virus infections. Obviously, miRNAs play a central role in the regulation of gene transcription in viral replication and host immune defense. A healthy diet and nutraceuticals can support the fine-tuning of miRNAs. Objectives: The aim of this study was to analyze the effects of epigenetic active phytoceuticals and/or functional foods on immune relevant miRNAs and mRNAs in a healthy human study population. Methods: In a 2-month human intervention study (n=80), a mix of plant extracts (sage extract, green tea extract, berberine, apple extract, onion extract, elderberry extract, and grape skin extract) with proven activity against RNA viruses were examined for the change of miRNA and mRNA patterns involved in virus response systems. Lifestyle and nutritional behavior, including self-reported stress levels, as well as infection frequency as potential cofounders have been raised. Results: The intervention with secondary plant extracts could modulate the expression of miRNAs involved in the virus defense (miR-30e, miR-877, miR-150) and the expression of NF-κB. The intervention also increased miRNA expression patterns associated with a positive lifestyle. The intervention adapted miRNAs that correlate with an increased risk of infection, smoking, stress, and processed meat products.Conclusion: Plant extracts can enhance the beneficial effects of a healthy nutrition and lifestyle by modulating miRNAs. MiRNAs are promising drug targets for maintaining immune homeostasis.Keywords: antiviral, epigenetic active nutraceutical, miRNA, secondary plant extracts, virus response, plant ingredients, functional foods

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“…Triazole is an important nitrogen heterocyclic compound, containing three nitrogen atoms and two carbon atoms. It had reported that compounds containing triazole have an important application value in various fields, such as ( Brüggemann et al, 2022 ; Fallah et al, 2022 ; Sharma et al, 2022 ) agrochemistry ( Georgiadis et al, 2018 ; Musarurwa and Tavengwa, 2021 ; Valencia-Quintana et al, 2022 ) and material chemistry ( Scattergood et al, 2017 ; Rodrigues et al, 2020 ; Ahmed and Xiong, 2021 ). Its unique structure facilitates the formation of a variety of non-covalent bonds with enzymes and receptors inducing broad-spectrum biological activities, such as anticancer ( Sharma et al, 2022 ), antituberculosis ( Keri et al, 2015 ; Zhang et al, 2017 ), antibacterial ( Gao et al, 2019 ; Zhang, 2019 ; Strzelecka and Swiatek, 2021 ), and anti-HIV ( Patel et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

et al. 2022

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Triazole, comprising three nitrogen atoms and two carbon atoms, is divided into two isomers 1,2,3-triazole and 1,2,4-triazole. Compounds containing a triazole are one of the significant heterocycles that exhibit broad biological activities, such as antimicrobial, analgesic, anti-inflammatory, anticonvulsant, antineoplastic, antimalarial, antiviral, antiproliferative, and anticancer activities. A great quantity of drugs with a triazole structure has been developed and proved, for example, ketoconazole and fluconazole. Given the importance of the triazole scaffold, its synthesis has attracted much attention. This review summarizes the synthetic methods of triazole compounds from various nitrogen sources in the past 20 years.

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miRNAs: A potentially valuable tool in pesticide toxicology assessment-current experimental and epidemiological data review

Cited by 10 publications

References 111 publications

Effect of Pesticide Exposure over DNA Damage in Farmers from Los Reyes, Michoacan in Mexico

Effect of Pesticide Exposure over DNA Damage in Farmers from Los Reyes, Michoacan in Mexico

Epigenetic active phytoceuticals activate immune relevant miRNAs important in virus response systems

Synthesis methods of 1,2,3-/1,2,4-triazoles: A review

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