miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents

Qian, Biyun; Nag, Subhasree; Su, Yue; Voruganti, Sukesh; Qin, Jiang‐Jiang; Zhang, Ruiwen; Cho, William C. S.

doi:10.2174/15680096113139990031

Cited by 30 publications

(27 citation statements)

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“…Similarly, the lincRNA antisense noncoding RNA in the INK4 locus (ANRIL) and the PRC1 protein CBX7 interact to repress the Ink4b/Ink4a/ARF locus in prostate cancer cells . In recent years, small noncoding RNAs have been recognized as major players in regulatory pathways, and many of them are deregulated in cancers . While several miRNAs bind to and inhibit PCG expression (Fig.…”

Section: Pcg Proteins and Cancermentioning

confidence: 99%

“…230 In recent years, small noncoding RNAs have been recognized as major players in regulatory pathways, and many of them are deregulated in cancers. 231 While several miR-NAs bind to and inhibit PCG expression ( Fig. 8A), multiple miRNAs are themselves repressed in embryonic stem cells and are marked by H3K27me3 modification, indicating that PRC2 complexes regulate their expression.…”

Section: Noncoding Rnasmentioning

confidence: 99%

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Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

Wang

Qin

Voruganti

et al. 2015

Medicinal Research Reviews

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105

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Polycomb group (PcG) proteins are transcriptional repressors that regulate several crucial developmental and physiological processes in the cell. More recently, they have been found to play important roles in human carcinogenesis and cancer development and progression. The deregulation and dysfunction of PcG proteins often lead to blocking or inappropriate activation of developmental pathways, enhancing cellular proliferation, inhibiting apoptosis, and increasing the cancer stem cell population. Genetic and molecular investigations of PcG proteins have long been focused on their PcG functions. However, PcG proteins have recently been shown to exert non-polycomb functions, contributing to the regulation of diverse cellular functions. We and others have demonstrated that PcG proteins regulate the expression and function of several oncogenes and tumor suppressor genes in a PcG-independent manner, and PcG proteins are associated with the survival of patients with cancer. In this review, we summarize the recent advances in the research on PcG proteins, including both the polycomb-repressive and non-polycomb functions. We specifically focus on the mechanisms by which PcG proteins play roles in cancer initiation, development, and progression. Finally, we discuss the potential value of PcG proteins as molecular biomarkers for the diagnosis and prognosis of cancer, and as molecular targets for cancer therapy.

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Section: Pcg Proteins and Cancermentioning

confidence: 99%

Section: Noncoding Rnasmentioning

confidence: 99%

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

Wang

Qin

Voruganti

et al. 2015

Medicinal Research Reviews

Self Cite

105

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“…MicroRNAs (miRNAs) are a family of small, non‐coding RNAs that negatively regulate gene expression at the post‐transcriptional level, play important roles in a great many biologic processes (Bartel, ; Yanaihara et al, ). Increasing bodies of evidences demonstrate that miRNAs are often dysregulated in human cancers and act as oncogenes or tumor suppressors (Qian et al, ). Several miRNAs have been reported to regulate NSCLC carcinogenesis, including miR‐27b, miR‐10a, and miR‐33a (Jiang et al, ; Yang et al, ; Yu et al, ).…”

Section: Introductionmentioning

confidence: 99%

MicroRNA‐455 suppresses non‐small cell lung cancer through targeting ZEB1

Chen

Tang

et al. 2016

Cell Biology International

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MicroRNA-455 (miRNA-455), which is downregulated in human cancer, potently mediates the multiple steps of carcinogenesis. However, the role of miR-455 in non-small cell lung cancer (NSCLC) carcinogenesis remains unclear. In present study, we determined the mature miRNA-455 expression in NSCLC tissues and cells by real-time PCR. Follow-up studies examined the effects of a miR-455 mimic (gain of function) on cell proliferation, migration, and invasion. Our data indicate that miR-455 was significantly down-regulated in NSCLC cell lines and tissues. In functional assays, overexpression of miR-455 suppressed the proliferation, migration, and invasion of NSCLC cell lines. Data from reporter assays showed that miR-455 directly binds to 3'UTR of ZEB1 and suppresses the endogenous level of ZEB1 protein expression. Furthermore, overexpression of ZEB1 reverses miR-455-suppressed malignant phenotype of NSCLC cells. Moreover, we found that upregulation of ZEB1 expression is inversely associated with miR-455 expression in NSCLC tissues. Taken together, miR-455 as an anti-oncogene in non-small cell lung cancer through up-regulation of ZEB1 and serve as a potential therapeutic target in NSCLC.

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“…Despite the use of various detection methods, including microarray, sequencing, real-time polymerase chain reaction-based approaches and in situ hybridisation, a high consistency of miRNA expression profiles exists among these studies, which indicates that these miRNAs are essential elements in cancer progression (16)(17)(18)(19).…”

Section: Reciprocal Regulation Between Micrornas and Epigenetic Machimentioning

confidence: 99%

Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer

Feng

Wang

et al. 2017

Oncology Letters

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Abstract. Epigenetics encompasses changes in DNA methylation, histone and chromatin structure, and non-coding RNAs, specifically microRNA (miRNA) expression. Recent advances in the rapidly evolving field of colorectal cancer (CRC) epigenetics have revealed a complicated network of reciprocal interconnections between miRNAs and other epigenetic machinery. On the one hand, miRNA expression may be regulated by epigenetic mechanisms including DNA methylation and histone modifications. However, miRNAs may affect the epigenetic machinery by directly targeting its enzymatic components. In this study, we focus on the colorectal miRNA expression profile and further illustrate the reciprocal regulation in CRC, with the aim of offering new insights into the strategies of combatting the disease.

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miRNAs in Cancer Prevention and Treatment and as Molecular Targets for Natural Product Anticancer Agents

Cited by 30 publications

References 0 publications

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

Polycomb Group (PcG) Proteins and Human Cancers: Multifaceted Functions and Therapeutic Implications

MicroRNA‐455 suppresses non‐small cell lung cancer through targeting ZEB1

Reciprocal regulation between microRNAs and epigenetic machinery in colorectal cancer

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