Mirnas profile in patients with brain arteriovenous malformation

Paschoal, Eric Homero Albuquerque; Jong-A-Liem, Glaucia Suzanna; Yamaki, Vítor Nagai; Paschoal, Fernando Mendes; Jesus, Joel Monteiro de; Burbano, Rommel Mário Rodrigues; Tuji, Fabrício Mesquita; Bastos, Vanessa Albuquerque Paschoal Aviz; Neto, Feres Eduardo Aparecido Chaddad; Yamada, Elizabeth Sumi; Teixeira, Manoel Jacobsen; Figueiredo, Eberval Gadelha; Santos, Ândrea Ribeiro dos; Bor‐Seng‐Shu, Edson; Santos, Leonardo Magalhães

doi:10.1055/s-0038-1673172

Cited by 1 publication

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“…They also reported that miR-17 and miR-19a-3p whose target genes were related to vascular remodeling and extracellular matrix remodeling have a role in ruptured bAVMs. 24 Additional studies with higher sample size and varied disease phenotypes may help to clear the ambiguity about the role of miR-18a in bAVM pathogenesis. The role of vascular remodeling, including angiogenesis in bAVM formation is, however, irrefutable.…”

Section: Ncrnas Associated With Sporadic Bavmsmentioning

confidence: 99%

Molecular Biomarkers and Drug Targets in Brain Arteriovenous and Cavernous Malformations: Where Are We?

Venugopal

Sumi

2022

Stroke

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Vascular malformations of the brain (VMB) comprise abnormal development of blood vessels. A small fraction of VMBs causes hemorrhages with neurological morbidity and risk of mortality in patients. Most often, they are symptomatically silent and are detected at advanced stages of disease progression. The most common forms of VMBs are arteriovenous and cavernous malformations in the brain. Radiopathological features of these diseases are complex with high phenotypic variability. Early detection of these malformations followed by preclusion of severe neurological deficits such as hemorrhage and stroke is crucial in the clinical management of patients with VMBs. The technological advances in high-throughput omics platforms have currently infused a zest in translational research in VMBs. Besides finding novel biomarkers and therapeutic targets, these studies have withal contributed significantly to the understanding of the etiopathogenesis of VMBs. Here we discuss the recent advances in predictive and prognostic biomarker research in sporadic and familial arteriovenous malformations as well as cerebral cavernous malformations. Furthermore, we analyze the clinical applicability of protein and noncoding RNA-based molecular-targeted therapies which may have a potentially key role in disease management.

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Section: Ncrnas Associated With Sporadic Bavmsmentioning

confidence: 99%