miRNAs: Targets to Investigate Herpesvirus Infection Associated with Neurological Disorders

de Souza Carneiro, Vanessa Cristine; Leon, Luciane Almeida Amado; de Paula, Vanessa Salete

doi:10.3390/ijms242115876

IJMS

2023

DOI: 10.3390/ijms242115876

|View full text |Cite

miRNAs: Targets to Investigate Herpesvirus Infection Associated with Neurological Disorders

Vanessa Cristine de Souza Carneiro,

Luciane Almeida Amado Leon,

Vanessa Salete de Paula

Abstract: Herpesvirus is associated with various neurological disorders and a specific diagnosis is associated with a better prognosis. MicroRNAs (miRNAs) are potential diagnostic and prognostic biomarkers of neurological diseases triggered by herpetic infection. In this review, we discuss miRNAs that have been associated with neurological disorders related to the action of herpesviruses. Human miRNAs and herpesvirus-encoded miRNAs were listed and discussed. This review article will be valuable in stimulating the search… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 154 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

A review of HSV pathogenesis, vaccine development, and advanced applications

Bai,

Xu,

Zeng

et al. 2024

Mol Biomed

View full text Add to dashboard Cite

Herpes simplex virus (HSV), an epidemic human pathogen threatening global public health, gains notoriety for its complex pathogenesis that encompasses lytic infection of mucosal cells, latent infection within neurons, and periodic reactivation. This intricate interplay, coupled with HSV's sophisticated immune evasion strategies, gives rise to various diseases, including genital lesions, neonatal encephalitis, and cancer. Despite more than 70 years of relentless research, an effective preventive or therapeutic vaccine against HSV has yet to emerge, primarily due to the limited understanding of virus-host interactions, which in turn impedes the identification of effective vaccine targets. However, HSV's unique pathological features, including its substantial genetic load capacity, high replicability, transmissibility, and neurotropism, render it a promising candidate for various applications, spanning oncolytic virotherapy, gene and immune therapies, and even as an imaging tracer in neuroscience. In this review, we comprehensively update recent breakthroughs in HSV pathogenesis and immune evasion, critically summarize the progress made in vaccine candidate development, and discuss the multifaceted applications of HSV as a biological tool. Importantly, we highlight both success and challenges, emphasizing the critical need for intensified research into HSV, with the aim of providing deeper insights that can not only advance HSV treatment strategies but also broaden its application horizons.

show abstract

A review of HSV pathogenesis, vaccine development, and advanced applications

Bai,

Xu,

Zeng

et al. 2024

Mol Biomed

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

miRNAs: Targets to Investigate Herpesvirus Infection Associated with Neurological Disorders

Cited by 1 publication

References 154 publications

A review of HSV pathogenesis, vaccine development, and advanced applications

A review of HSV pathogenesis, vaccine development, and advanced applications

Contact Info

Product

Resources

About