miRNAs: The hidden bioactive component of milk

Rani, Payal; Yenuganti, Vengala Rao; Shandilya, Shruti; Onteru, Suneel Kumar; Singh, Dheer

doi:10.1016/j.tifs.2017.05.007

Cited by 26 publications

(24 citation statements)

References 82 publications

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“…In milk, both human and bovine, MEX have been shown to transfer their RNA-derived cargo to immune cells to potentially modulate immune cell function (Lakkaraju and Rodriguez-Boulan, 2008;Hata et al, 2010;Zempleni et al, 2017). In general, exosomes and nanovesicles are secreted by both eukaryotic and prokaryotic cells (via exocytosis of multivesicular bodies) into the environment for cell-to-cell communication, protection, and exchange of genetic information (Nieuwland and Sturk, 2010;Colombo et al, 2014;Kalra et al, 2016;Rani et al, 2017). They dock on to the surfaces of recipient cells, where they transmit signals from the cell surface and transfer their contents to produce functional responses (French et al, 2017).…”

Section: Composition Of Milk Phospholipidsmentioning

confidence: 99%

Symposium review: The relevance of bovine milk phospholipids in human nutrition—Evidence of the effect on infant gut and brain development

Ortega‐Anaya

Jiménez-Flores

2019

Journal of Dairy Science

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This paper reflects the concepts reviewed during the presentation in the Joint MILK/Lactation Biology Symposium at the ADSA 2018 Annual Meeting. Our intention is to update the concepts and advances in the area of research regarding milk phospholipids or polar lipid fraction as part of a dairy ingredient used today in nutritional studies that focus on gut health as well as brain development of infants. Although processing advances have allowed the production of novel ingredients rich in milk fat globule membrane (MFGM) components, mostly monitored by phospholipid concentration and presence of membrane proteins, there is wide variability in their composition and structure. Furthermore, we aimed to include in the phospholipid fraction of milk nanovesicles designated as milk exosomes, which are secreted into milk by different secretion mechanisms than those of the fat globules but are also made up of a unique mixture of polar lipids. We consider imperative the study of polar lipid-derived structures from milk regarding composition and structure to gain insights into their biological effect in human health. Nevertheless, and tolerating the differences in composition and concentration of their components, studies supplementing the diet of infants with polar lipids (i.e., MFGM components) have shown significant advances in several areas of human health and well-being. Here we present a summary of the important components of MFGM and milk exosomes as well as an overview of the effects on gut health and brain and cognitive development when added to the diet of infants.

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Section: Composition Of Milk Phospholipidsmentioning

confidence: 99%

Symposium review: The relevance of bovine milk phospholipids in human nutrition—Evidence of the effect on infant gut and brain development

Ortega‐Anaya

Jiménez-Flores

2019

Journal of Dairy Science

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“…They have biological function and are regarded as highly prominent ingredients for health promoting, functional foods or pharmaceutical preparations. Apart from the conventional knowledge, recent research is being carried out to investigate the "hidden" properties of milk, respectively the component that is present in milk and also possess a biological function in human organism, miRNA (microRNA) (Rani et al, 2017). The increasing number of studies that have been published over the past few years concerning bioactive components in foods, mostly in milk and dairy products, suggest that there is an increasing interest in their identification and application in both, food and industry.…”

Section: Bioactive Peptidesmentioning

confidence: 99%

“…This question implies for itself that there are some gaps in detailed knowledge about the understanding and as well knowing the exact composition of milk. Recently, group of scientists (Rani et al, 2017) established the presence of bioactive component from milk, miRNA (microRNA). The presence of miRNAs has been established in almost every biological fluid.…”

Section: Novel Bioactive Component From Milkmentioning

confidence: 99%

“…Milk as well as other biological fluids contains miRNAs, which are called the "Milk miRNAs". Milk miRNAs have been isolated from different fractions from milk like lipid fraction, exosomal fractions or from whey fraction (Rani et al, 2017). For isolation of miRNA different methods have been used like the Trizol LS extraction, the miRNeasy kit, the mir-Vana miRNA isolation kit and the quantitative RT-PCR, which are the most frequently, used ones (Lekchnov et al, 2016).…”

Section: Novel Bioactive Component From Milkmentioning

confidence: 99%

“…miR-24 significantly represses phagocytotic processes and associated inflammatory cytokines in cells. Most of miRNAs are involved in immune-stimulating processes (Rani et al, 2017) and thus play an important role in the human health.…”

Section: Novel Bioactive Component From Milkmentioning

confidence: 99%

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Bioactive components derived from bovine milk

Barukčić

Božanić

2019

Mljekarstvo.com

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In recent years, functional foods and bioactive components in foods have drawn a lot of attention as well as interest of food scientists, nutritionists, health professionals, and consumers. The advent of this new food category has been facilitated by increasing scientific knowledge about the metabolic and genomic effects of diet and specific dietary components on human health. The relationship between health and diet is well known and it is a main key for prevention of variety of diseases. Milk is considered as a very good source of bioactive components and it has been known to contain macro-as well as micronutrients of high nutritional and therapeutic value. Also, bioactive components have been exploited from milk and dairy products for application in functional foods and for potential pharmaceutical use. Biologically active compounds guard neonates and adults against pathogens and illnesses. Some major bioactive components of milk are derived from caseins, whey proteins, lipids, lactoferrine, vitamins, immunoglobulins and growth factors. The aim of this paper was to provide an overview and explain the health effects of already known and recently detected bioactive components derived from bovine milk on humans.

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Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

Xu,

Yang,

Wang

et al. 2023

Advanced Science

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Early life nutrition can reprogram development and exert long‐term consequences on body weight regulation. In mice, maternal high‐fat diet (HFD) during lactation predisposed male but not female offspring to diet‐induced obesity when adult. Molecular and cellular changes in the hypothalamus at important time points are examined in the early postnatal life in relation to maternal diet and demonstrated sex‐differential hypothalamic reprogramming. Maternal HFD in lactation decreased the neurotropic development of neurons formed at the embryo stage (e12.5) and impaired early postnatal neurogenesis in the hypothalamic regions of both males and females. Males show a larger increased ratio of Neuropeptide Y (NPY) to Pro‐opiomelanocortin (POMC) neurons in early postnatal neurogenesis, in response to maternal HFD, setting an obese tone for male offspring. These data provide insights into the mechanisms by which hypothalamic reprograming by early life overnutrition contributes to the sex‐dependent susceptibility to obesity in adult life in mice.

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miRNAs: The hidden bioactive component of milk

Cited by 26 publications

References 82 publications

Symposium review: The relevance of bovine milk phospholipids in human nutrition—Evidence of the effect on infant gut and brain development

Symposium review: The relevance of bovine milk phospholipids in human nutrition—Evidence of the effect on infant gut and brain development

Bioactive components derived from bovine milk

Maternal High Fat Diet in Lactation Impacts Hypothalamic Neurogenesis and Neurotrophic Development, Leading to Later Life Susceptibility to Obesity in Male but Not Female Mice

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