Miro-mediated mitochondrial transport: A new dimension for disease-related abnormal cell metabolism?

Li, Yanxing; Yang, Zhen; Zhang, Shumei; Li, Jianjun

doi:10.1016/j.bbrc.2024.149737

Biochemical and Biophysical Research Communications

2024

DOI: 10.1016/j.bbrc.2024.149737

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Miro-mediated mitochondrial transport: A new dimension for disease-related abnormal cell metabolism?

Yanxing Li,

Zhen Yang,

Shumei Zhang

et al.

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The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

Reshetniak,

Bogaciu,

Bonn

et al. 2024

The Journal of Physiology

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The synaptic vesicle cluster (SVC) is an essential component of chemical synapses, which provides neurotransmitter‐loaded vesicles during synaptic activity, at the same time as also controlling the local concentrations of numerous exo‐ and endocytosis cofactors. In addition, the SVC hosts molecules that participate in other aspects of synaptic function, from cytoskeletal components to adhesion proteins, and affects the location and function of organelles such as mitochondria and the endoplasmic reticulum. We argue here that these features extend the functional involvement of the SVC in synapse formation, signalling and plasticity, as well as synapse stabilization and metabolism. We also propose that changes in the size of the SVC coalesce with changes in the postsynaptic compartment, supporting the interplay between pre‐ and postsynaptic dynamics. Thereby, the SVC could be seen as an ‘all‐in‐one’ regulator of synaptic structure and function, which should be investigated in more detail, to reveal molecular mechanisms that control synaptic function and heterogeneity. image

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The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

Reshetniak,

Bogaciu,

Bonn

et al. 2024

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

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Miro-mediated mitochondrial transport: A new dimension for disease-related abnormal cell metabolism?

Cited by 1 publication

References 218 publications

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

The synaptic vesicle cluster as a controller of pre‐ and postsynaptic structure and function

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