Mirogabalin improves cancer-associated pain but increases the risk of malignancy in mice with pancreatic cancer

Itaya, Tomoaki; Sano, Makoto; Kajiwara, Ichie; Oshima, Y; Kuramochi, Tomoya; Kim, Jin-Suk; Ichimaru, Yoshimi; Kitajima, Osamu; Masamune, Atsushi; Ijichi, Hideaki; Ishii, Yoshinori; Suzuki, Takahiro

doi:10.1097/j.pain.0000000000002852

Cited by 1 publication

(2 citation statements)

References 38 publications

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“…[45] In contrast, mirogabalin (a selective voltage-gated calcium channel α2δ ligand) exhibits a positive effect on cancer-associated pain while concurrently promoting the proliferative potential of pancreatic ductal adenocarcinoma. [46] In addition to hypersensitivity and hyperplasia of neurons, nociceptors alteration is also within the scope of neural plasticity. MiRNA was found to suppress key molecules especially nociceptive receptors related to chronic pain and was showed to participate in PCRP.…”

Section: Neural Remodeling and Plasticitymentioning

confidence: 99%

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Pancreatic cancer-related pain: mechanism and management

Wu,

Zhu,

Shen

2023

Journal of Pancreatology

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Pancreatic cancer related pain (PCRP) gains widespread attention for its high prevalence, extreme complexity, poor prognosis and decreased survival rate. Current treatment of PCRP remains unsatisfactory, since the underlying mechanism is not clear. The occurrence of PCRP is mainly related to the neurotropic nature of pancreatic cancer, and perineural invasion, neural remodeling and plasticity play important roles. Upon the understanding of PCRP mechanism, the management of PCRP is a multidisciplinary and multifaceted strategy. Traditional pain medications, invasive or intervention treatment, psychological support, integrative therapy and palliative care are all the potential aspects for the management of PCRP.

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Section: Neural Remodeling and Plasticitymentioning

confidence: 99%

Section: Mechanism Of Pcrpmentioning

confidence: 99%