Mirror asymmetry of Category and Letter fluency in traumatic brain injury and Alzheimer’s patients

Capitani, Erminio; Rosci, Chiara; Saetti, Maria Cristina; Laiacona, Marcella

doi:10.1016/j.neuropsychologia.2008.09.016

Cited by 30 publications

(25 citation statements)

References 16 publications

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“…The worse performance of AD patients in Category Fluency as compared to Letter Fluency (56.7 vs. 41.5% of pathological scores) replicates independent data [1], where 65% of the AD patients were pathological on Category Fluency and 49% on Letter Fluency. The main question was to understand why, among AD patients, category fluency is more severely impaired than letter fluency.…”

Section: Discussionsupporting

confidence: 70%

“…the pathology/normality boundary. There was no overlap between the AD sample investigated here and that studied by Capitani et al [1]. …”

Section: Methodsmentioning

confidence: 62%

“…On the McNemar test, there were significantly more AD patients showing errors on Category Fluency only (n = 11) than on Letter Fluency only (n = 3), with a two-sided p value of 0.033. Taking the available norms as a reference [1], we calculated the mean adjusted fluency scores of the AD group and the z scores corresponding to the discrepancy between the control means and the AD group means. The mean z score of Category Fluency was −1.601, and that of Letter Fluency was −1.176.…”

Section: Resultsmentioning

confidence: 99%

“…Patients are often examined on both category fluency and letter fluency [1,2]. The discrepant pattern observed in different pathological groups seems consistent with the general claim that the deficits in category fluency and letter fluency have distinct roots: Alzheimer's dementia (AD) patients are relatively more impaired on category fluency, whereas traumatic brain injury patients show the opposite pattern and commit more errors on letter fluency [1]. …”

Section: Introductionmentioning

confidence: 84%

“…The score corresponded to the mean number of words uttered on the three trials corresponding to each initial letter. For a procedure description and reference norms, see Capitani et al [1]. Age- and education-adjusted scores were considered pathological when they were lower than 7.1.…”

Section: Methodsmentioning

confidence: 99%

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On Which Abilities Are Category Fluency and Letter Fluency Grounded A Confirmatory Factor Analysis of 53 Alzheimer's Dementia Patients

Bizzozero¹,

Scotti²,

Clerici

et al. 2013

Dement Geriatr Cogn Disord Extra

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Background/Aims: In Alzheimer's dementia (AD), letter fluency is less impaired than category fluency. To check whether category fluency and letter fluency depend differently on semantics and attention, 53 mild AD patients were given animal and letter fluency tasks, two semantic tests (the Verbal Semantic Questionnaire and the BORB Association Match test), and two attentional tests (the Stroop Colour-Word Interference test and the Digit Cancellation test). Methods: We conducted a LISREL confirmatory factor analysis to check the extent to which category fluency and letter fluency tasks were related to semantics and attention, viewed as latent variables. Results: Both types of fluency tasks were related to the latent variable Semantics but not to the latent variable Attention. Conclusions: Our findings warn against interpreting the disproportionate impairment of AD patients on category and letter fluency as a contrast between semantics and attention.

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Section: Discussionsupporting

confidence: 70%

“…the pathology/normality boundary. There was no overlap between the AD sample investigated here and that studied by Capitani et al [1]. …”

Section: Methodsmentioning

confidence: 62%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 84%

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

On Which Abilities Are Category Fluency and Letter Fluency Grounded A Confirmatory Factor Analysis of 53 Alzheimer's Dementia Patients

Bizzozero¹,

Scotti²,

Clerici

et al. 2013

Dement Geriatr Cogn Disord Extra

Self Cite

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Semantic loss marks early Alzheimer's disease‐related neurodegeneration in older adults without dementia

Vonk

Bouteloup

Mangin

et al. 2020

Alzheimer's & Dementia: Diagnosis, Assessment &

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Objective To assess progression of semantic loss in early stages of cognitive decline using semantic and letter fluency performance, and its relation with Alzheimer's disease (AD)‐specific neurodegeneration using longitudinal multimodal neuroimaging measures. Methods Change in verbal fluency was analyzed among 2261 non‐demented individuals with a follow‐up diagnosis of no mild cognitive impairment (MCI), amnestic MCI (aMCI), non‐amnestic MCI (naMCI), or incident dementia, using linear mixed models across 4 years of follow‐up, and relations with magnetic resonance imaging (MRI; n = 1536) and 18 F‐fluorodeoxyglucose brain positron emission tomography ( 18 F‐FDG‐PET) imaging (n = 756) using linear regression models across 2 years of follow‐up. Results Semantic fluency declined—fastest in those at higher risk for AD (apolipoprotein E [APOE] e4 carriers, Clinical Dementia Rating score of .5, aMCI, or incident dementia)—while letter fluency did not except for those with incident dementia. Lower baseline semantic fluency was associated with an increase in white matter hyperintensities and total mean cortical thinning over time, and regionally with less hippocampal volume as well as more cortical thinning and reduced 18 F‐FDG‐PET uptake in the inferior parietal lobule, entorhinal cortex, isthmus cingulate, and precuneus–posterior cingulate area. In contrast, baseline letter fluency was not associated with change in total nor regional neurodegeneration. Whole‐brain neurodegeneration over time was associated with faster decline in both fluencies, while AD‐specific regions were associated with a faster rate of decline in semantic but not letter fluency. Interpretation This study provides strong evidence of distinctive degeneration of semantic abilities early on in relation to both cognitive decline and AD‐specific neurodegeneration.

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Current awareness in geriatric psychiatry

2009

Int J Geriat Psychiatry

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In order to keep subscribers up‐to‐date with the latest developments in their field, John Wiley & Sons are providing a current awareness service in each issue of the journal. The bibliography contains newly published material in the field of geriatric psychiatry. Each bibliography is divided into 9 sections: 1 Reviews; 2 General; 3 Assessment; 4 Epidemiology; 5 Therapy; 6 Care; 7 Dementia; 8 Depression; 9 Psychology. Within each section, articles are listed in alphabetical order with respect to author. If, in the preceding period, no publications are located relevant to any one of these headings, that section will be omitted

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Mirror asymmetry of Category and Letter fluency in traumatic brain injury and Alzheimer’s patients

Cited by 30 publications

References 16 publications

On Which Abilities Are Category Fluency and Letter Fluency Grounded A Confirmatory Factor Analysis of 53 Alzheimer's Dementia Patients

On Which Abilities Are Category Fluency and Letter Fluency Grounded A Confirmatory Factor Analysis of 53 Alzheimer's Dementia Patients

Semantic loss marks early Alzheimer's disease‐related neurodegeneration in older adults without dementia

Current awareness in geriatric psychiatry

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